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Protein

Ethylene receptor 1

Gene

ETR1

Organism
Brassica oleracea (Wild cabbage)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Cu cationBy similarityNote: Binds 1 copper ion per dimer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651CopperBy similarity
Metal bindingi69 – 691CopperBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase

Keywords - Biological processi

Ethylene signaling pathway, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Copper, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 947.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene receptor 1 (EC:2.7.13.3)
Gene namesi
Name:ETR1
OrganismiBrassica oleracea (Wild cabbage)
Taxonomic identifieri3712 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Ethylene receptor 1PRO_0000081413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 – 4InterchainBy similarity
Disulfide bondi6 – 6InterchainBy similarity
Modified residuei353 – 3531Phosphohistidine; by autocatalysisPROSITE-ProRule annotationBy similarity
Modified residuei657 – 65714-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliO49230.
SMRiO49230. Positions 604-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 307150GAFAdd
BLAST
Domaini350 – 586237Histidine kinasePROSITE-ProRule annotationAdd
BLAST
Domaini609 – 726118Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ethylene receptor family.Curated
Contains 1 GAF domain.Curated
Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O49230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVCNCIEPQ WPADELLMKY QYISDFFIAV AYFSIPLELI YFVKKSAVFP
60 70 80 90 100
YRWVLVQFGA FIVLCGATHL INLWTFTTHS RTVALVMTTA KVLTAVVSCA
110 120 130 140 150
TALMLVHIIP DLLSVKTREL FLKNKAAELD REMGLIRTQE ETGRHVRMLT
160 170 180 190 200
HEIRSTLDRH TILKTTLVEL GRTLALEECA LWMPTRTGLE LQLSYTLRQQ
210 220 230 240 250
HPVEYTVPIQ LPVINQVFGT SRAVKISPNS PVARLRPVSG KYLLGEVVAV
260 270 280 290 300
RVPLLHLSNF QINDWPELST KRYALMVLML PSDSARQWHV HELELVEVVA
310 320 330 340 350
DQVAVALSHA AILEESMRAR DLLMEQNVAL DIARREAETA IRARNDFLAV
360 370 380 390 400
MNHEMRTPMH AIIALSSLLQ ETELTPEQRL MVETVLKSSS LLATLMNDVL
410 420 430 440 450
DLSRLEDGSL QLELGTFNLH TLFREVLNLI KPIAVVKKLP ITLNLAPDLP
460 470 480 490 500
EFVVGDEKRL MQIILNIVGN AVKFSKQGSI SVTALVTKSD NRAPPDFFVV
510 520 530 540 550
PTGSHFYLRV KVKDLGAGIN PQDIPKLFTK FAQTQSLATR SSGGSGLGLA
560 570 580 590 600
ISKRFVNLME GNIWIESEGV GKGCTAIFDV KLAISNESKQ SGIPKVPANP
610 620 630 640 650
QHVNFAGLKV LVMDENGVSR MVTKGLLVHL GCEVTTVSSN EECLRVVSHE
660 670 680 690 700
HRVVFMDVCT PGVENYQIAL RIHEKFTKRH QRPLLVALTG NTDKSTKEKC
710 720 730
MSFGLDGVLL KPVSLDNMRN VLSDRLEHRV LYEAM
Length:735
Mass (Da):82,240
Last modified:June 1, 1998 - v1
Checksum:i520B77291CF2BCC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047476 mRNA. Translation: AAC39497.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047476 mRNA. Translation: AAC39497.1.

3D structure databases

ProteinModelPortaliO49230.
SMRiO49230. Positions 604-733.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.13.3. 947.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of a broccoli cDNA encoding an ETR-type ethylene receptor."
    Chen H.-H., Charng Y.-Y., Yang S.F., Shaw J.-F.
    Plant Gene Register PGR98-088
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiETR1_BRAOL
AccessioniPrimary (citable) accession number: O49230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 1998
Last modified: February 17, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.