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Protein

L-lactate dehydrogenase

Gene

LDH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (LDH1), L-lactate dehydrogenase (At4g17260), L-lactate dehydrogenase (AXX17_At4g20330), L-lactate dehydrogenase (dl4665w), L-lactate dehydrogenase
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126SubstrateUniRule annotation1
Binding sitei158SubstrateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1
Active sitei213Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

BioCyciARA:AT4G17260-MONOMER
ReactomeiR-ATH-70268 Pyruvate metabolism
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:LDH1Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Subcellular locationi

Expressioni

Gene expression databases

ExpressionAtlasiO49191 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliO49191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 180Ldh_1_NInterPro annotationAdd BLAST140
Domaini183 – 346Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
PhylomeDBiO49191

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

O49191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKNASTSSL KDLGPSGLDL TSAFFKPIHN SDPSLPSNRR TKVSVVGVGN
60 70 80 90 100
VGMAIAQTIL TQDLADEIAL VDAKPDKLRG EMLDLQHAAA FLPRTKITAS
110 120 130 140 150
VDYEVTAGSD LCIVTAGARQ NPGESRLNLL QRNVALFRHI IPPLAKASPD
160 170 180 190 200
SILIVVSNPV DVLTYVAWKL SGFPVNRVLG SGTNLDSSRF RFLIADHLDV
210 220 230 240 250
NAQDVQAFIV GEHGDSSVAL WSSISVGGIP VLSFLEKNQI AYEKQTLEDI
260 270 280 290 300
HQAVVGSAYE VIGLKGYTSW AIGYSVANLA RTILRDQRKI HPVTVLARGF
310 320 330 340 350
YGVDGGDVFL SLPALLGRNG VVAVTNVHMT DEEAEKLQKS AKTILEMQSQ

LGL
Length:353
Mass (Da):37,936
Last modified:June 1, 1998 - v1
Checksum:i359FCDD3CF31260E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043130 Genomic DNA Translation: AAC02678.1

Similar proteinsi

Entry informationi

Entry nameiO49191_ARATH
AccessioniPrimary (citable) accession number: O49191
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health