Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ethylene receptor 2

Gene

ETR2

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Cu cationBy similarityNote: Binds 1 copper ion per dimer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64CopperBy similarity1
Metal bindingi68CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase

Keywords - Biological processi

Ethylene signaling pathway, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Copper, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 3101.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene receptor 2 (EC:2.7.13.3)
Short name:
LeETR2
Gene namesi
Name:ETR2
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814171 – 736Ethylene receptor 2Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3InterchainBy similarity
Disulfide bondi5InterchainBy similarity
Modified residuei351Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei6614-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO49187.

Expressioni

Tissue specificityi

Leaves, flowers and fruits.

Developmental stagei

Induced in imbibing seeds prior to germination and down-regulated in elongating seedlings and senescing leaf petioles.

Inductioni

Not induced by ethylene.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi4081.Solyc07g056580.2.1.

Structurei

3D structure databases

ProteinModelPortaliO49187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 305GAFAdd BLAST149
Domaini348 – 585Histidine kinasePROSITE-ProRule annotationAdd BLAST238
Domaini613 – 730Response regulatoryPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Belongs to the ethylene receptor family.Curated
Contains 1 GAF domain.Curated
Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0519. Eukaryota.
COG0642. LUCA.
InParanoidiO49187.
KOiK14509.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O49187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCNCFDPLL PADELLMKYQ YISDFFIAVA YFSIPIELVY FVQKSAVFPY
60 70 80 90 100
RWVLVQFGAF IVLCGATHLI NLWTSTPHTR TVAMVMTTAK FSTAAVSCAT
110 120 130 140 150
AVMLVHIIPD LLSVKTRELF LKNKAAELDR EMGLIRTQEE TGRYVRMLTH
160 170 180 190 200
EIRSTLDRHT ILKTTLVELG RALQLEECAL WMPTRTGVEL QLSYTLHHQN
210 220 230 240 250
PVGFTVPIQL PVINQVFSAN CAVKISPNSA VARLRPTRKY IPGEVVAVRV
260 270 280 290 300
PLLHLSNFQT NDWPELSPKS YALMVLMLPS NSARQWHVHE LELVDVVADQ
310 320 330 340 350
VAVALSHAAI LEESMRARDL LIEQNVALDL ARREAETAVR ARNDFLGVMN
360 370 380 390 400
HEMRTPMHAV VALSSLLQES ELIPEQRLMV ETILKSSNLL ATLINDVLDL
410 420 430 440 450
SRLEDGSLQL DVGTFNLHAL FREVLNLIKP VAAVKKLFVT LSLSSDFPEV
460 470 480 490 500
AIGDEKRLMQ ILLNVVGNAV KFSKEGSVSV SAVNAKSESL IDPRAPEFFP
510 520 530 540 550
VQSENHFYLR VQVKDTGSGI NPQDFPKLFC KFAQNQEPAT KNSAGTGLGL
560 570 580 590 600
AICKRFVNLM EGHIWIESEG VGKGSTAIFI VKLGIPGRLN ESKLPFTAGL
610 620 630 640 650
PANHMQMTFQ GLKVLVMDDN GFSRMVTKSL LVHLGCDVTT IGSGDECLRI
660 670 680 690 700
LTREHKVLIM DASITGMNCY DVAVSVHEKF GKRLERPLIV ALTGNTDQVT
710 720 730
KENCLRVGMD GVILKPVSID KMRSVLSGLL EHGTVL
Length:736
Mass (Da):81,701
Last modified:June 1, 1998 - v1
Checksum:iA804C61EBC190320
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti474K → E in AAB39386 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043085 mRNA. Translation: AAC02214.1.
U47279 mRNA. Translation: AAB39386.1.
PIRiT06271.
RefSeqiNP_001234153.2. NM_001247224.2.
UniGeneiLes.3500.

Genome annotation databases

GeneIDi606299.
KEGGisly:606299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043085 mRNA. Translation: AAC02214.1.
U47279 mRNA. Translation: AAB39386.1.
PIRiT06271.
RefSeqiNP_001234153.2. NM_001247224.2.
UniGeneiLes.3500.

3D structure databases

ProteinModelPortaliO49187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc07g056580.2.1.

Proteomic databases

PaxDbiO49187.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi606299.
KEGGisly:606299.

Phylogenomic databases

eggNOGiKOG0519. Eukaryota.
COG0642. LUCA.
InParanoidiO49187.
KOiK14509.

Enzyme and pathway databases

BRENDAi2.7.13.3. 3101.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETR2_SOLLC
AccessioniPrimary (citable) accession number: O49187
Secondary accession number(s): Q41343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.