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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

TIF3C1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-ATH-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-ATH-72689. Formation of a pool of free 40S subunits.
R-ATH-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-ATH-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8UniRule annotation
eIF3 p110UniRule annotation
p105
Gene namesi
Name:TIF3C1
Ordered Locus Names:At3g56150
ORF Names:F18O21_110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G56150.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytosol Source: TAIR
  • eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  • eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  • eukaryotic translation initiation factor 3 complex Source: GO_Central
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 900900Eukaryotic translation initiation factor 3 subunit CPRO_0000123527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351PhosphotyrosineCombined sources
Modified residuei38 – 381PhosphoserineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei204 – 2041PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO49160.
PRIDEiO49160.

PTM databases

iPTMnetiO49160.

Expressioni

Gene expression databases

GenevisibleiO49160. AT.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex (Potential) (PubMed:9849901, PubMed:15548739). Binds to the translation initiation factors TIF3C1 and TIF3H1 (PubMed:15548739, PubMed:9849901). Interacts with CSN1 (Potential) (PubMed:9849901). Associates with the CSN (COP9 signalosome) complex (PubMed:9849901). Binds to the translation initiation factors TIF3C1 and TIF3H1 (PubMed:15548739, PubMed:9849901).UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9M4T62EBI-1635551,EBI-1635581
At5g61200F4K2104EBI-1635551,EBI-7216904
ATPK1P428182EBI-1635551,EBI-8107038
TIF3E1Q9C5Z33EBI-1635551,EBI-1635572
TORQ9FR533EBI-1635551,EBI-1382370

GO - Molecular functioni

Protein-protein interaction databases

BioGridi10097. 11 interactions.
IntActiO49160. 13 interactions.
MINTiMINT-7980051.
STRINGi3702.AT3G56150.1.

Structurei

3D structure databases

ProteinModelPortaliO49160.
SMRiO49160. Positions 236-802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini643 – 773131PCIUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1076. Eukaryota.
ENOG410XRU3. LUCA.
HOGENOMiHOG000029414.
InParanoidiO49160.
KOiK03252.
OMAiINEMWED.
PhylomeDBiO49160.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

O49160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRFFTQVG SESEDESDYE VEVNEVQNDD VNNRYLQSGS EDDDDTDTKR
60 70 80 90 100
VVKPAKDKRF EEMTYTVDQM KNAMKINDWV SLQENFDKVN KQLEKVMRIT
110 120 130 140 150
EAVKPPTLYI KTLVMLEDFL NEALANKEAK KKMSTSNSKA LNSMKQKLKK
160 170 180 190 200
NNKLYEDDIN KYREAPEVEE EKQPEDDDDD DDDDDEVEDD DDSSIDGPTV
210 220 230 240 250
DPGSDVDEPT DNLTWEKMLS KKDKLLEKLM NKDPKEITWD WVNKKFKEIV
260 270 280 290 300
AARGKKGTAR FELVDQLTHL TKIAKTPAQK LEILFSVISA QFDVNPGLSG
310 320 330 340 350
HMPINVWKKC VLNMLTILDI LVKYSNIVVD DTVEPDENET SKPTDYDGKI
360 370 380 390 400
RVWGNLVAFL ERVDTEFFKS LQCIDPHTRE YVERLRDEPM FLALAQNIQD
410 420 430 440 450
YFERMGDFKA AAKVALRRVE AIYYKPQEVY DAMRKLAELV EEEEETEEAK
460 470 480 490 500
EESGPPTSFI VVPEVVPRKP TFPESSRAMM DILVSLIYRN GDERTKARAM
510 520 530 540 550
LCDINHHALM DNFVTARDLL LMSHLQDNIQ HMDISTQILF NRTMAQLGLC
560 570 580 590 600
AFRAGMITES HSCLSELYSG QRVRELLAQG VSQSRYHEKT PEQERMERRR
610 620 630 640 650
QMPYHMHLNL ELLEAVHLIC AMLLEVPNMA ANSHDAKRRV ISKNFRRLLE
660 670 680 690 700
ISERQAFTAP PENVRDHVMA ATRALTKGDF QKAFEVLNSL EVWRLLKNRD
710 720 730 740 750
SILDMVKDRI KEEALRTYLF TYSSSYESLS LDQLAKMFDV SEPQVHSIVS
760 770 780 790 800
KMMINEELHA SWDQPTRCIV FHEVQHSRLQ SLAFQLTEKL SILAESNERA
810 820 830 840 850
MESRTGGGGL DLSSRRRDNN QDYAGAASGG GGYWQDKANY GQGRQGNRSG
860 870 880 890 900
YGGGRSSGQN GQWSGQNRGG GYAGRVGSGN RGMQMDGSSR MVSLNRGVRT
Length:900
Mass (Da):102,949
Last modified:September 19, 2002 - v2
Checksum:i84EA72DDE49A05C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651Y → N in AAC83464 (PubMed:9849901).Curated
Sequence conflicti254 – 2541G → E in AAC83464 (PubMed:9849901).Curated
Sequence conflicti275 – 2751K → N in AAC83464 (PubMed:9849901).Curated
Sequence conflicti569 – 5691S → F in AAC83464 (PubMed:9849901).Curated
Sequence conflicti710 – 7112IK → VQ in AAC83464 (PubMed:9849901).Curated
Sequence conflicti715 – 7151L → V in AAC83464 (PubMed:9849901).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040102 mRNA. Translation: AAC83464.1.
AL163763 Genomic DNA. Translation: CAB87414.1.
CP002686 Genomic DNA. Translation: AEE79486.1.
CP002686 Genomic DNA. Translation: AEE79487.1.
AY064006 mRNA. Translation: AAL36362.1.
BT001961 mRNA. Translation: AAN71960.1.
PIRiT47732.
T50773.
RefSeqiNP_001190102.1. NM_001203173.1.
NP_191174.1. NM_115473.2.
UniGeneiAt.5061.

Genome annotation databases

EnsemblPlantsiAT3G56150.1; AT3G56150.1; AT3G56150.
AT3G56150.2; AT3G56150.2; AT3G56150.
GeneIDi824781.
GrameneiAT3G56150.1; AT3G56150.1; AT3G56150.
AT3G56150.2; AT3G56150.2; AT3G56150.
KEGGiath:AT3G56150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040102 mRNA. Translation: AAC83464.1.
AL163763 Genomic DNA. Translation: CAB87414.1.
CP002686 Genomic DNA. Translation: AEE79486.1.
CP002686 Genomic DNA. Translation: AEE79487.1.
AY064006 mRNA. Translation: AAL36362.1.
BT001961 mRNA. Translation: AAN71960.1.
PIRiT47732.
T50773.
RefSeqiNP_001190102.1. NM_001203173.1.
NP_191174.1. NM_115473.2.
UniGeneiAt.5061.

3D structure databases

ProteinModelPortaliO49160.
SMRiO49160. Positions 236-802.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10097. 11 interactions.
IntActiO49160. 13 interactions.
MINTiMINT-7980051.
STRINGi3702.AT3G56150.1.

PTM databases

iPTMnetiO49160.

Proteomic databases

PaxDbiO49160.
PRIDEiO49160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G56150.1; AT3G56150.1; AT3G56150.
AT3G56150.2; AT3G56150.2; AT3G56150.
GeneIDi824781.
GrameneiAT3G56150.1; AT3G56150.1; AT3G56150.
AT3G56150.2; AT3G56150.2; AT3G56150.
KEGGiath:AT3G56150.

Organism-specific databases

TAIRiAT3G56150.

Phylogenomic databases

eggNOGiKOG1076. Eukaryota.
ENOG410XRU3. LUCA.
HOGENOMiHOG000029414.
InParanoidiO49160.
KOiK03252.
OMAiINEMWED.
PhylomeDBiO49160.

Enzyme and pathway databases

ReactomeiR-ATH-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-ATH-72689. Formation of a pool of free 40S subunits.
R-ATH-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-ATH-72702. Ribosomal scanning and start codon recognition.

Miscellaneous databases

PROiO49160.

Gene expression databases

GenevisibleiO49160. AT.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex."
    Karniol B., Yahalom A., Kwok S., Tsuge T., Matsui M., Deng X.-W., Chamovitz D.A.
    FEBS Lett. 439:173-179(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CSN1 AND TIF3E1, SUBUNIT.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h."
    Kim T.-H., Kim B.-H., Yahalom A., Chamovitz D.A., von Arnim A.G.
    Plant Cell 16:3341-3356(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIF3H1.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Root.
  7. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
    Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
    J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: cv. Columbia.
  8. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38; SER-40 AND SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEIF3C_ARATH
AccessioniPrimary (citable) accession number: O49160
Secondary accession number(s): Q9LYM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 19, 2002
Last modified: March 16, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.