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O49139

- CMT1_ARATH

UniProt

O49139 - CMT1_ARATH

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Protein
Putative DNA (cytosine-5)-methyltransferase CMT1
Gene
CMT1, At1g80740, F23A5.9
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Protein uncertaini

Functioni

May be involved in the CpXpG methylation and in gene silencing By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei417 – 4171 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: UniProtKB-KW
  3. chromatin binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA mediated transformation Source: TAIR
  2. chromatin modification Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciARA:AT1G80740-MONOMER.

Protein family/group databases

REBASEi3261. M.AthCMT1P.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative DNA (cytosine-5)-methyltransferase CMT1 (EC:2.1.1.37)
Alternative name(s):
Chromomethylase 1
Protein CHROMOMETHYLASE 1
Gene namesi
Name:CMT1
Ordered Locus Names:At1g80740
ORF Names:F23A5.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G80740.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 791791Putative DNA (cytosine-5)-methyltransferase CMT1
PRO_0000246691Add
BLAST

Proteomic databases

PaxDbiO49139.
PRIDEiO49139.

Expressioni

Tissue specificityi

Expressed in flowers. Not detected in leaves, roots, seedlings and plants prior formation of flower buds.1 Publication

Gene expression databases

GenevestigatoriO49139.

Structurei

3D structure databases

ProteinModelPortaliO49139.
SMRiO49139. Positions 12-778.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 199121BAH
Add
BLAST
Domaini225 – 768544SAM-dependent MTase C5-type
Add
BLAST
Domaini339 – 40466Chromo
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili308 – 33326 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 BAH domain.
Contains 1 chromo domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0270.
InParanoidiO49139.
KOiK00558.
OMAiFGMASQG.
PhylomeDBiO49139.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001025. BAH_dom.
IPR001525. C5_MeTfrase.
IPR025821. C5_MeTfrase_pln.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF01426. BAH. 1 hit.
PF00385. Chromo. 1 hit.
PF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
PR00504. CHROMODOMAIN.
SMARTiSM00439. BAH. 1 hit.
SM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 4 hits.
SSF54160. SSF54160. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O49139-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAARNKQKKR AEPESDLCFA GKPMSVVEST IRWPHRYQSK KTKLQAPTKK    50
PANKGGKKED EEIIKQAKCH FDKALVDGVL INLNDDVYVT GLPGKLKFIA 100
KVIELFEADD GVPYCRFRWY YRPEDTLIER FSHLVQPKRV FLSNDENDNP 150
LTCIWSKVNI AKVPLPKITS RIEQRVIPPC DYYYDMKYEV PYLNFTSADD 200
GSDASSSLSS DSALNCFENL HKDEKFLLDL YSGCGAMSTG FCMGASISGV 250
KLITKWSVDI NKFACDSLKL NHPETEVRNE AAEDFLALLK EWKRLCEKFS 300
LVSSTEPVES ISELEDEEVE ENDDIDEAST GAELEPGEFE VEKFLGIMFG 350
DPQGTGEKTL QLMVRWKGYN SSYDTWEPYS GLGNCKEKLK EYVIDGFKSH 400
LLPLPGTVYT VCGGPPCQGI SGYNRYRNNE APLEDQKNQQ LLVFLDIIDF 450
LKPNYVLMEN VVDLLRFSKG FLARHAVASF VAMNYQTRLG MMAAGSYGLP 500
QLRNRVFLWA AQPSEKLPPY PLPTHEVAKK FNTPKEFKDL QVGRIQMEFL 550
KLDNALTLAD AISDLPPVTN YVANDVMDYN DAAPKTEFEN FISLKRSETL 600
LPAFGGDPTR RLFDHQPLVL GDDDLERVSY IPKQKGANYR DMPGVLVHNN 650
KAEINPRFRA KLKSGKNVVP AYAISFIKGK SKKPFGRLWG DEIVNTVVTR 700
AEPHNQCVIH PMQNRVLSVR ENARLQGFPD CYKLCGTIKE KYIQVGNAVA 750
VPVGVALGYA FGMASQGLTD DEPVIKLPFK YPECMQAKDQ I 791
Length:791
Mass (Da):89,219
Last modified:July 25, 2006 - v2
Checksum:iA5ECFDBC274B215C
GO
Isoform 2 (identifier: O49139-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     568-570: VTN → CCR
     571-791: Missing.

Note: Alternative splice site used 50% of the time in cv. Columbia.

Show »
Length:570
Mass (Da):64,557
Checksum:iD08B184B4F3C6ADA
GO

Sequence cautioni

The sequence AAA98912.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481D → G in strain: cv. Metz-0.
Natural varianti196 – 1961T → I in strain: cv. Kl-0.
Natural varianti198 – 1981A → T in strain: cv. No-0.
Natural varianti249 – 791543Missing in strain: cv. Metz-0.
Add
BLAST
Natural varianti560 – 5601D → V in strain: cv. Landsberg erecta, cv. No-0 and cv. RLD.
Natural varianti561 – 791231Missing in strain: cv. Landsberg erecta, cv. No-0 and cv. RLD.
Add
BLAST
Natural varianti604 – 6041F → C in strain: cv. Nd-1, Nd-0 and cv. Kl-0.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei568 – 5703VTN → CCR in isoform 2.
VSP_019857
Alternative sequencei571 – 791221Missing in isoform 2.
VSP_019858Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039364 mRNA. Translation: AAB95485.1.
AF039366 Genomic DNA. Translation: AAC02659.1.
AF039367 Genomic DNA. Translation: AAC02660.1.
AF039368 Genomic DNA. Translation: AAC02661.1.
AF039369 Genomic DNA. Translation: AAC02662.1.
AF039370 Genomic DNA. Translation: AAC02663.1.
AF039371 Genomic DNA. Translation: AAC02665.1.
AF039372 Genomic DNA. Translation: AAC02667.1.
AF039373 Genomic DNA. Translation: AAC02668.1.
U53501 Genomic DNA. Translation: AAA98912.1. Sequence problems.
AC011713 Genomic DNA. Translation: AAF14662.1.
CP002684 Genomic DNA. Translation: AEE36442.1.
PIRiH96839.
RefSeqiNP_565245.1. NM_106722.2. [O49139-1]
UniGeneiAt.5460.

Genome annotation databases

EnsemblPlantsiAT1G80740.1; AT1G80740.1; AT1G80740. [O49139-1]
GeneIDi844413.
KEGGiath:AT1G80740.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039364 mRNA. Translation: AAB95485.1 .
AF039366 Genomic DNA. Translation: AAC02659.1 .
AF039367 Genomic DNA. Translation: AAC02660.1 .
AF039368 Genomic DNA. Translation: AAC02661.1 .
AF039369 Genomic DNA. Translation: AAC02662.1 .
AF039370 Genomic DNA. Translation: AAC02663.1 .
AF039371 Genomic DNA. Translation: AAC02665.1 .
AF039372 Genomic DNA. Translation: AAC02667.1 .
AF039373 Genomic DNA. Translation: AAC02668.1 .
U53501 Genomic DNA. Translation: AAA98912.1 . Sequence problems.
AC011713 Genomic DNA. Translation: AAF14662.1 .
CP002684 Genomic DNA. Translation: AEE36442.1 .
PIRi H96839.
RefSeqi NP_565245.1. NM_106722.2. [O49139-1 ]
UniGenei At.5460.

3D structure databases

ProteinModelPortali O49139.
SMRi O49139. Positions 12-778.
ModBasei Search...

Protein family/group databases

REBASEi 3261. M.AthCMT1P.

Proteomic databases

PaxDbi O49139.
PRIDEi O49139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G80740.1 ; AT1G80740.1 ; AT1G80740 . [O49139-1 ]
GeneIDi 844413.
KEGGi ath:AT1G80740.

Organism-specific databases

TAIRi AT1G80740.

Phylogenomic databases

eggNOGi COG0270.
InParanoidi O49139.
KOi K00558.
OMAi FGMASQG.
PhylomeDBi O49139.

Enzyme and pathway databases

BioCyci ARA:AT1G80740-MONOMER.

Gene expression databases

Genevestigatori O49139.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR001025. BAH_dom.
IPR001525. C5_MeTfrase.
IPR025821. C5_MeTfrase_pln.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF01426. BAH. 1 hit.
PF00385. Chromo. 1 hit.
PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
PR00504. CHROMODOMAIN.
SMARTi SM00439. BAH. 1 hit.
SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 4 hits.
SSF54160. SSF54160. 1 hit.
PROSITEi PS51038. BAH. 1 hit.
PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A DNA methyltransferase homolog with a chromodomain exists in multiple polymorphic forms in Arabidopsis."
    Henikoff S., Comai L.
    Genetics 149:307-318(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: cv. Columbia, cv. Kl-0, cv. Landsberg erecta, cv. Metz-0, cv. Nd-0, cv. Nd-1 and cv. RLD.
  2. "A 37.5 Kb sequence from Arabidopsis thaliana chromosome I."
    Goodman H.M., Gallant P., Keifer-Higgins S., Rubenfield M., Church G.M.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiCMT1_ARATH
AccessioniPrimary (citable) accession number: O49139
Secondary accession number(s): O49137
, O49138, O49141, O50057, O50073, Q38940, Q7G196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi