Reviewed, UniProtKB/Swiss-Prot O49071 (IMPP_MESCR)

Names and origin

Protein names

Recommended name:
    Inositol monophosphatase
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase
      Short name=IMPase
      Short name=IMP

Gene names

Name:

IMP1

Organism

Mesembryanthemum crystallinum (Common ice plant)

Taxonomic identifier

3544 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Aizoaceae › Mesembryanthemum

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides.
Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Enzyme regulation	Inhibited by Li+ By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC lithium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Inositol monophosphatase		PRO_0000142526
Regions
	Region	93 – 96	4	Substrate binding By similarity
	Region	194 – 196	3	Substrate binding By similarity
Sites
	Metal binding	71	1	Magnesium 1 By similarity
	Metal binding	91	1	Magnesium 1 By similarity
	Metal binding	91	1	Magnesium 2 By similarity
	Metal binding	93	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	94	1	Magnesium 2 By similarity
	Metal binding	221	1	Magnesium 2 By similarity
	Binding site	71	1	Substrate By similarity
	Binding site	213	1	Substrate By similarity
	Binding site	221	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O49071-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 0C045EB33D903A6C	FASTA	270	29,161
	10 20 30 40 50 60 MAANVPLSDF LATAVDAAKR AGEVIRKGFY VKKNVEHKGQ VDLVTETDKS CEDIIFNCLK 70 80 90 100 110 120 QQYPNHKFIG EETTAAYGAT ELTDEPTWIV DPLDGTTNFV HGFPFVCVSI GLTIGKVPTV 130 140 150 160 170 180 GVVYNPIMNE LFTGVRRQGA FLNGVPIHVS SKDELVNCLL VTEVGTKRDK STVDATTNRI 190 200 210 220 230 240 NGLLFKVRSI RMAGSCALDL CGIACGRADL MYENGYGGAW DVTAGIVIVE EAGGVIFDPS 250 260 270 GKDFDITVTR IAASNPLIKD SFVEAFKQAE

References

[1]	Nelson D.E., Bohnert H.J. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF037220 mRNA. Translation: AAB92418.1.
PIR	T12205.
3D structure databases
HSSP	HSSP built from PDB template 1IMF based on UniProtKB P29218.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.3.25. 2210.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR020552. Inositol_monoPase_Li-sen. IPR000760. Inositol_monophosphatase. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00377. IMPHPHTASES. PR00378. LIIMPHPHTASE.
ProDom	PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00629. IMP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IMPP_MESCR

Accession

Primary (citable) accession number: O49071

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	September 22, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)