Reviewed, UniProtKB/Swiss-Prot O49069 (GPX4_GOSHI)

Names and origin

Protein names	Recommended name:     Probable phospholipid hydroperoxide glutathione peroxidase       Short name=PHGPx     EC=1.11.1.12
Organism	Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Taxonomic identifier	3635 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Malvales › Malvaceae › Malvoideae › Gossypium

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.
Catalytic activity	2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.
Subcellular location	CytoplasmPotential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro phospholipid-hydroperoxide glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Probable phospholipid hydroperoxide glutathione peroxidase		PRO_0000066628
Sites
	Active site	43	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O49069-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 32FE5856B9B40F82	FASTA	170	18,854
	10 20 30 40 50 60 MASQSSKPQS IYDFTVKDAK GNDVDLSIYK GKVLIIVNVA SQCGLTNSNY TDLTEIYKKY 70 80 90 100 110 120 KDQGLEILAF PCNQFGGQEP GSIEESIQNM VCTRFKAEYP IFDKVDVNGD NAAPLYKFLK 130 140 150 160 170 SSKGGFFGDS IKWNFSKFLV DKEGNVVDRY SPTTTPASME KDIKKLLGVA

References

[1]	"Glutathione peroxidase from cotton, partial cDNA." Jaradat T.T., Allen R. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Coker 312.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF037051 mRNA. Translation: AAB94892.1.
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	2648. GhGPx06-1.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR001452. SH3. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE. PR00452. SH3DOMAIN.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX4_GOSHI

Accession

Primary (citable) accession number: O49069

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)