O49069 (GPX4_GOSHI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Probable phospholipid hydroperoxide glutathione peroxidase Short name=PHGPx EC=1.11.1.12
Organism	Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Taxonomic identifier	3635 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Malvales › Malvaceae › Malvoideae › Gossypium

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.
Catalytic activity	2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro phospholipid-hydroperoxide glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Probable phospholipid hydroperoxide glutathione peroxidase		PRO_0000066628
Sites
	Active site	43	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O49069 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 32FE5856B9B40F82	FASTA	170	18,854
	10 20 30 40 50 60 MASQSSKPQS IYDFTVKDAK GNDVDLSIYK GKVLIIVNVA SQCGLTNSNY TDLTEIYKKY 70 80 90 100 110 120 KDQGLEILAF PCNQFGGQEP GSIEESIQNM VCTRFKAEYP IFDKVDVNGD NAAPLYKFLK 130 140 150 160 170 SSKGGFFGDS IKWNFSKFLV DKEGNVVDRY SPTTTPASME KDIKKLLGVA

References

[1]	"Glutathione peroxidase from cotton, partial cDNA." Jaradat T.T., Allen R. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Coker 312.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF037051 mRNA. Translation: AAB94892.1.
3D structure databases
ProteinModelPortal	O49069.
SMR	O49069. Positions 5-169.
ModBase	Search...
Protein family/group databases
PeroxiBase	2648. GhGPx06-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX4_GOSHI

Accession

Primary (citable) accession number: O49069

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	June 1, 1998
Last modified:	July 27, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program