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Protein

Ethylene receptor

Gene

ETR1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Cu cationBy similarityNote: Binds 1 copper ion per dimer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64CopperBy similarity1
Metal bindingi68CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase

Keywords - Biological processi

Ethylene signaling pathway, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Copper, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 3645.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene receptor (EC:2.7.13.3)
Alternative name(s):
NT-ETR1
Gene namesi
Name:ETR1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814231 – 738Ethylene receptorAdd BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3InterchainBy similarity
Disulfide bondi5InterchainBy similarity
Modified residuei351Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei6614-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Inductioni

Constitutive expression. Not induced by senescence, wounding, application of ethephon or infection with virus.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliO48929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 305GAFAdd BLAST149
Domaini348 – 585Histidine kinasePROSITE-ProRule annotationAdd BLAST238
Domaini613 – 730Response regulatoryPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Belongs to the ethylene receptor family.Curated
Contains 1 GAF domain.Curated
Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O48929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCNCFDPQW PADELLMKYQ YISDFFIAVA YFSIPIELVY FVQKSAVFPY
60 70 80 90 100
RWVLVQFGAF IVLCGATHLI NLWTSTAHTR TLAIVMTTAK VLTAVVSCAT
110 120 130 140 150
ALMLVHIIPD LLSVKTRELF LKNKAAELDR EMGLIRTQEE TGRYVRMLTH
160 170 180 190 200
EIRSTLDRHT ILKTTLVELG RTLALEECAL WMPTPPGLEL QLSYTLRHQN
210 220 230 240 250
PIGFTVPIQL PVINQVFGTN RAVKISPNSP VARLRPAGKY MPGEVVAVRV
260 270 280 290 300
PLLHLSNFQI NDWPELSTKR YALMVLMLPS GSARQWHVHE LELVEVVADQ
310 320 330 340 350
VAVALSHAAI LEESMRARDL LMEQNVALDL ARREAEMAVR ARNDFLAVMN
360 370 380 390 400
HEMRTPMHAI IALSSLLQET ELTPEQRLMV ETILKSSNLL ATLINDVLDL
410 420 430 440 450
SRLEDGSLQL DVGTFNLHVL FRKVLNLIKP IASVKNCLSR LTCLQICPEF
460 470 480 490 500
AIGDEKRLMQ ILLNVVGNAV KFSKEGSVSI SAVAAKSESL SDPRAPEFFP
510 520 530 540 550
VQSENHFYLR VQVKDTGSGI NPQDIPKLFC KFAQNQALAT KSSGGTGLGL
560 570 580 590 600
AISKRFVNLM EGHIWIESEG LGKGSTAIFI VKLGIPGRSN EPKLPFMPRL
610 620 630 640 650
PANHMQMTFQ GLKVLIMDDN GFSRMVTKGL LVHLGCDVTT VSSGDECLRV
660 670 680 690 700
LTQEHKVVFM DVSIPGIDCY EVAVQIHEKF GKHHNRPLIV ALTGNTDRVT
710 720 730
KENCMRVGMD GVILKPVSVD KMRSVLSELL EHGVILQS
Length:738
Mass (Da):82,294
Last modified:June 1, 1998 - v1
Checksum:iD6C5F7B16F16A7DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022727 mRNA. Translation: AAB97160.1.
PIRiT01897.
UniGeneiNta.3590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022727 mRNA. Translation: AAB97160.1.
PIRiT01897.
UniGeneiNta.3590.

3D structure databases

ProteinModelPortaliO48929.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.13.3. 3645.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETR1_TOBAC
AccessioniPrimary (citable) accession number: O48929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.