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Protein

Ethylene receptor

Gene

ETR1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Cu cationBy similarityNote: Binds 1 copper ion per dimer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64CopperBy similarity1
Metal bindingi68CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase
Biological processEthylene signaling pathway, Two-component regulatory system
LigandATP-binding, Copper, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3 3645

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene receptor (EC:2.7.13.3)
Alternative name(s):
NT-ETR1
Gene namesi
Name:ETR1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814231 – 738Ethylene receptorAdd BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3InterchainBy similarity
Disulfide bondi5InterchainBy similarity
Modified residuei351Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei6614-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiO48929

Expressioni

Inductioni

Constitutive expression. Not induced by senescence, wounding, application of ethephon or infection with virus.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliO48929
SMRiO48929
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 305GAFAdd BLAST149
Domaini348 – 585Histidine kinasePROSITE-ProRule annotationAdd BLAST238
Domaini613 – 730Response regulatoryPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Belongs to the ethylene receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
cd00156 REC, 1 hit
Gene3Di3.30.450.40, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR014525 ETR
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01590 GAF, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF026389 Ethyln_sen_HK, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00065 GAF, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

O48929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCNCFDPQW PADELLMKYQ YISDFFIAVA YFSIPIELVY FVQKSAVFPY
60 70 80 90 100
RWVLVQFGAF IVLCGATHLI NLWTSTAHTR TLAIVMTTAK VLTAVVSCAT
110 120 130 140 150
ALMLVHIIPD LLSVKTRELF LKNKAAELDR EMGLIRTQEE TGRYVRMLTH
160 170 180 190 200
EIRSTLDRHT ILKTTLVELG RTLALEECAL WMPTPPGLEL QLSYTLRHQN
210 220 230 240 250
PIGFTVPIQL PVINQVFGTN RAVKISPNSP VARLRPAGKY MPGEVVAVRV
260 270 280 290 300
PLLHLSNFQI NDWPELSTKR YALMVLMLPS GSARQWHVHE LELVEVVADQ
310 320 330 340 350
VAVALSHAAI LEESMRARDL LMEQNVALDL ARREAEMAVR ARNDFLAVMN
360 370 380 390 400
HEMRTPMHAI IALSSLLQET ELTPEQRLMV ETILKSSNLL ATLINDVLDL
410 420 430 440 450
SRLEDGSLQL DVGTFNLHVL FRKVLNLIKP IASVKNCLSR LTCLQICPEF
460 470 480 490 500
AIGDEKRLMQ ILLNVVGNAV KFSKEGSVSI SAVAAKSESL SDPRAPEFFP
510 520 530 540 550
VQSENHFYLR VQVKDTGSGI NPQDIPKLFC KFAQNQALAT KSSGGTGLGL
560 570 580 590 600
AISKRFVNLM EGHIWIESEG LGKGSTAIFI VKLGIPGRSN EPKLPFMPRL
610 620 630 640 650
PANHMQMTFQ GLKVLIMDDN GFSRMVTKGL LVHLGCDVTT VSSGDECLRV
660 670 680 690 700
LTQEHKVVFM DVSIPGIDCY EVAVQIHEKF GKHHNRPLIV ALTGNTDRVT
710 720 730
KENCMRVGMD GVILKPVSVD KMRSVLSELL EHGVILQS
Length:738
Mass (Da):82,294
Last modified:June 1, 1998 - v1
Checksum:iD6C5F7B16F16A7DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022727 mRNA Translation: AAB97160.1
PIRiT01897
UniGeneiNta.3590

Similar proteinsi

Entry informationi

Entry nameiETR1_TOBAC
AccessioniPrimary (citable) accession number: O48929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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