ID   RLP23_ARATH             Reviewed;         890 AA.
AC   O48849;
DT   28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   27-MAR-2024, entry version 154.
DE   RecName: Full=Receptor like protein 23 {ECO:0000303|PubMed:18434605};
DE            Short=AtRLP23 {ECO:0000303|PubMed:18434605};
DE   Flags: Precursor;
GN   Name=RLP23 {ECO:0000303|PubMed:18434605};
GN   OrderedLocusNames=At2g32680 {ECO:0000312|Araport:AT2G32680};
GN   ORFNames=F24L7.18 {ECO:0000312|EMBL:AAC04495.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=15955925; DOI=10.1104/pp.104.054452;
RA   Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT   "Phylogenomic analysis of the receptor-like proteins of rice and
RT   Arabidopsis.";
RL   Plant Physiol. 138:611-623(2005).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18434605; DOI=10.1104/pp.108.119487;
RA   Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA   Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA   Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT   "A genome-wide functional investigation into the roles of receptor-like
RT   proteins in Arabidopsis.";
RL   Plant Physiol. 147:503-517(2008).
RN   [5]
RP   REVIEW.
RX   PubMed=25064074; DOI=10.1016/j.pbi.2014.07.007;
RA   Gust A.A., Felix G.;
RT   "Receptor like proteins associate with SOBIR1-type of adaptors to form
RT   bimolecular receptor kinases.";
RL   Curr. Opin. Plant Biol. 21:104-111(2014).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH SOBIR1.
RX   PubMed=24525519; DOI=10.4161/psb.27937;
RA   Bi G., Liebrand T.W., Cordewener J.H., America A.H., Xu X., Joosten M.H.;
RT   "Arabidopsis thaliana receptor-like protein AtRLP23 associates with the
RT   receptor-like kinase AtSOBIR1.";
RL   Plant Signal. Behav. 9:E27937-E27937(2014).
RN   [7]
RP   FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE, AND COMPONENT OF THE
RP   RLP23-SOBIR1-BAK1 COMPLEX.
RX   PubMed=27251392; DOI=10.1038/nplants.2015.140;
RA   Albert I., Boehm H., Albert M., Feiler C.E., Imkampe J., Wallmeroth N.,
RA   Brancato C., Raaymakers T.M., Oome S., Zhang H., Krol E., Grefen C.,
RA   Gust A.A., Chai J., Hedrich R., Van den Ackerveken G., Nuernberger T.;
RT   "An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity.";
RL   Nat. Plants 1:15140-15140(2015).
RN   [8]
RP   INDUCTION BY MANNITOL.
RX   PubMed=27099374; DOI=10.1093/jxb/erw152;
RA   Wu J., Liu Z., Zhang Z., Lv Y., Yang N., Zhang G., Wu M., Lv S., Pan L.,
RA   Joosten M.H., Wang G.;
RT   "Transcriptional regulation of receptor-like protein genes by environmental
RT   stresses and hormones and their overexpression activities in Arabidopsis
RT   thaliana.";
RL   J. Exp. Bot. 67:3339-3351(2016).
CC   -!- FUNCTION: Involved in the perception of necrosis and ethylene-inducing
CC       peptide 1-like proteins (NLPs), that act as extracellular signals
CC       mediating immune activation. Component of the RLP23-SOBIR1-BAK1 complex
CC       that mediates NLP-triggered immunity. {ECO:0000269|PubMed:27251392}.
CC   -!- SUBUNIT: Directly interacts with a 20-mer fragment (nlp20) from NLPs
CC       through its extracellular LRR domain. Component of a trimeric complex
CC       composed of RLP23, SOBIR1 and BAK1. BAK1 is recruited into a pre-formed
CC       RLP23-SOBIR1 complex in a ligand-dependent manner (PubMed:27251392).
CC       Interacts with SOBIR1 (PubMed:24525519, PubMed:27251392).
CC       {ECO:0000269|PubMed:24525519, ECO:0000269|PubMed:27251392}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: By mannitol. {ECO:0000269|PubMed:27099374}.
CC   -!- DISRUPTION PHENOTYPE: Impaired in nlp20-mediated immunity.
CC       {ECO:0000269|PubMed:27251392}.
CC   -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
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DR   EMBL; AC003974; AAC04495.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08715.1; -; Genomic_DNA.
DR   PIR; T00800; T00800.
DR   RefSeq; NP_180827.1; NM_128827.2.
DR   AlphaFoldDB; O48849; -.
DR   SMR; O48849; -.
DR   STRING; 3702.O48849; -.
DR   GlyCosmos; O48849; 17 sites, No reported glycans.
DR   PaxDb; 3702-AT2G32680-1; -.
DR   ProteomicsDB; 227996; -.
DR   EnsemblPlants; AT2G32680.1; AT2G32680.1; AT2G32680.
DR   GeneID; 817828; -.
DR   Gramene; AT2G32680.1; AT2G32680.1; AT2G32680.
DR   KEGG; ath:AT2G32680; -.
DR   Araport; AT2G32680; -.
DR   TAIR; AT2G32680; RLP23.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_000288_18_3_1; -.
DR   InParanoid; O48849; -.
DR   OMA; ISSERWD; -.
DR   OrthoDB; 654901at2759; -.
DR   PhylomeDB; O48849; -.
DR   PRO; PR:O48849; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O48849; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR   GO; GO:0002229; P:defense response to oomycetes; IMP:UniProtKB.
DR   GO; GO:0032491; P:detection of molecule of fungal origin; IMP:UniProtKB.
DR   GO; GO:0002758; P:innate immune response-activating signaling pathway; IMP:UniProtKB.
DR   GO; GO:0140426; P:pathogen-associated molecular pattern receptor signaling pathway; IMP:TAIR.
DR   GO; GO:0010555; P:response to mannitol; IMP:UniProtKB.
DR   GO; GO:0002237; P:response to molecule of bacterial origin; IMP:UniProtKB.
DR   GO; GO:0002238; P:response to molecule of fungal origin; IMP:UniProtKB.
DR   GO; GO:0002240; P:response to molecule of oomycetes origin; IMP:UniProtKB.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR046956; RLP23-like.
DR   PANTHER; PTHR48061:SF55; DISEASE RESISTANCE LIKE PROTEIN; 1.
DR   PANTHER; PTHR48061; LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1-LIKE-RELATED; 1.
DR   Pfam; PF00560; LRR_1; 3.
DR   Pfam; PF13516; LRR_6; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00365; LRR_SD22; 4.
DR   SMART; SM00369; LRR_TYP; 10.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   PROSITE; PS51450; LRR; 15.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane; Plant defense;
KW   Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..890
FT                   /note="Receptor like protein 23"
FT                   /id="PRO_5011945105"
FT   TOPO_DOM        23..850
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        851..871
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        872..890
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          97..121
FT                   /note="LRR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          123..145
FT                   /note="LRR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          146..171
FT                   /note="LRR 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          173..195
FT                   /note="LRR 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          196..218
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          220..243
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          244..268
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          270..290
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          291..316
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          318..339
FT                   /note="LRR 10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          340..363
FT                   /note="LRR 11"
FT                   /evidence="ECO:0000255"
FT   REPEAT          364..389
FT                   /note="LRR 12"
FT                   /evidence="ECO:0000255"
FT   REPEAT          391..411
FT                   /note="LRR 13"
FT                   /evidence="ECO:0000255"
FT   REPEAT          412..436
FT                   /note="LRR 14"
FT                   /evidence="ECO:0000255"
FT   REPEAT          438..461
FT                   /note="LRR 15"
FT                   /evidence="ECO:0000255"
FT   REPEAT          462..485
FT                   /note="LRR 16"
FT                   /evidence="ECO:0000255"
FT   REPEAT          487..506
FT                   /note="LRR 17"
FT                   /evidence="ECO:0000255"
FT   REPEAT          507..527
FT                   /note="LRR 18"
FT                   /evidence="ECO:0000255"
FT   REPEAT          528..551
FT                   /note="LRR 19"
FT                   /evidence="ECO:0000255"
FT   REPEAT          553..575
FT                   /note="LRR 20"
FT                   /evidence="ECO:0000255"
FT   REPEAT          577..598
FT                   /note="LRR 21"
FT                   /evidence="ECO:0000255"
FT   REPEAT          599..623
FT                   /note="LRR 22"
FT                   /evidence="ECO:0000255"
FT   REPEAT          626..650
FT                   /note="LRR 23"
FT                   /evidence="ECO:0000255"
FT   REPEAT          699..724
FT                   /note="LRR 24"
FT                   /evidence="ECO:0000255"
FT   REPEAT          726..747
FT                   /note="LRR 25"
FT                   /evidence="ECO:0000255"
FT   REPEAT          748..771
FT                   /note="LRR 26"
FT                   /evidence="ECO:0000255"
FT   REPEAT          773..796
FT                   /note="LRR 27"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        207
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        242
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        265
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        351
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        461
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        505
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        518
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        574
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        730
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        778
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   890 AA;  98482 MW;  297578445B6357EF CRC64;
     MSKALLHLHF LSLFLLCCVC HSSIFTLNFH FTGIVACRPH QIQAFTKFTN EFDTRGCNNS
     DTFNGVWCDN STGAVAVLQL RKCLSGTLKS NSSLFGFHQL RYVDLQNNNL TSSSLPSGFG
     NLKRLEGLFL SSNGFLGQVP SSFSNLTMLA QLDLSYNKLT GSFPLVRGLR KLIVLDLSYN
     HFSGTLNPNS SLFELHQLRY LNLAFNNFSS SLPSKFGNLH RLENLILSSN GFSGQVPSTI
     SNLTRLTKLY LDQNKLTSSF PLVQNLTNLY ELDLSYNKFF GVIPSSLLTL PFLAHLALRE
     NNLAGSVEVS NSSTSSRLEI MYLGSNHFEG QILEPISKLI NLKHLDLSFL NTSYPIDLKL
     FSSLKSLRSL DLSGNSISSA SLSSDSYIPL TLEMLTLRHC DINEFPNILK TLKELVYIDI
     SNNRMKGKIP EWLWSLPLLQ SVTLGNNYFT GFQGSAEILV NSSVLLLYLD SNNFEGALPD
     LPLSIKGFGV ASNSFTSEIP LSICNRSSLA AIDLSYNNFT GPIPPCLRNL ELVYLRNNNL
     EGSIPDALCD GASLRTLDVS HNRLTGKLPR SFVNCSSLKF LSVINNRIED TFPFWLKALP
     NLQVLTLRSN RFYGPISPPH QGPLGFPELR IFEISDNKFT GSLPPNYFVN WKASSRTMNQ
     DGGLYMVYEE KLFDEGGYGY TDALDLQYKG LHMEQAKALT SYAAIDFSGN RLEGQIPESI
     GLLKALIAVN ISNNAFTGHI PLSMANLENL ESLDMSRNQL SGTIPNGLGS ISFLAYINVS
     HNQLTGEIPQ GTQITGQSKS SFEGNAGLCG LPLKESCFGT GAPPMYHQKQ EDKEEEEEEE
     EEEEEVLNGR AVAIGYGSGL LLGLAIAQVI ASYKPEWLVK IIGLNKRRKR
//