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Protein

3-ketoacyl-CoA synthase 11

Gene

KCS11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Active on both saturated and mono-unsaturated acyl chains C16 to C20.1 Publication

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.1 Publication

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei236By similarity1
Active sitei315By similarity1
Active sitei399By similarity1
Active sitei403By similarity1
Active sitei436By similarity1

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: UniProtKB-UniPathway
  • response to cold Source: TAIR
  • response to light stimulus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciARA:AT2G26640-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA synthase 111 Publication (EC:2.3.1.1991 Publication)
Short name:
KCS-111 Publication
Alternative name(s):
Very long-chain fatty acid condensing enzyme 111 Publication
Short name:
VLCFA condensing enzyme 111 Publication
Gene namesi
Name:KCS111 Publication
Ordered Locus Names:At2g26640Imported
ORF Names:F18A8.1Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G26640.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002491031 – 5093-ketoacyl-CoA synthase 11Add BLAST509

Proteomic databases

PaxDbiO48780.
PRIDEiO48780.

Expressioni

Tissue specificityi

Only expressed in guard cells. Expressed in siliques, flowers, leaves, stems, roots and seedlings (PubMed:18465198).1 Publication

Inductioni

Repressed by herbicides such as flufenacet and benfuresate (PubMed:12916765). Down-regulated by darkness and low temperature (PubMed:18465198).2 Publications

Gene expression databases

GenevisibleiO48780. AT.

Interactioni

Protein-protein interaction databases

BioGridi2557. 1 interactor.
IntActiO48780. 1 interactor.
STRINGi3702.AT2G26640.1.

Structurei

3D structure databases

ProteinModelPortaliO48780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 381FAESequence analysisAdd BLAST290

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated
Contains 1 FAE (fatty acid elongase) domain.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMW. Eukaryota.
ENOG410Y5VH. LUCA.
HOGENOMiHOG000238893.
InParanoidiO48780.
KOiK15397.
OMAiAMVISME.
OrthoDBiEOG093606UZ.
PhylomeDBiO48780.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012392. 3-ktacl-CoA_syn.
IPR013747. ACP_syn_III_C.
IPR013601. FAE1_typ3_polyketide_synth.
IPR016039. Thiolase-like.
[Graphical view]
PANTHERiPTHR31561. PTHR31561. 1 hit.
PfamiPF08541. ACP_syn_III_C. 1 hit.
PF08392. FAE1_CUT1_RppA. 1 hit.
[Graphical view]
PIRSFiPIRSF036417. 3-ktacl-CoA_syn. 1 hit.
SUPFAMiSSF53901. SSF53901. 3 hits.

Sequencei

Sequence statusi: Complete.

O48780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVEQKKPLI ESSDRNLPDF KKSVKLKYVK LGYHYLITHG MYLFLSPLVL
60 70 80 90 100
VIAAQISTFS VTDLRSLWEH LQYNLISVVV CSMLLVFLMT IYFMTRPRPV
110 120 130 140 150
YLVNFSCFKP DESRKCTKKI FMDRSKLTGS FTEENLEFQR KILQRSGLGE
160 170 180 190 200
STYLPEAVLN VPPNPCMKEA RKEAETVMFG AIDELLAKTN VNPKDIGILI
210 220 230 240 250
VNCSLFNPTP SLSAMVVNHY KLRGNILSYN LGGMGCSAGL ISIDLAKHLL
260 270 280 290 300
HSIPNTYAMV ISMENITLNW YFGNDRSKLV SNCLFRMGGA AILLSNKRWD
310 320 330 340 350
RRRSKYELVD TVRTHKGADD KCFGCITQEE DSASKIGVTL SKELMAVAGD
360 370 380 390 400
ALKTNITTLG PLVLPTSEQL LFFATLVGRK LFKMKIKPYI PDFKLAFEHF
410 420 430 440 450
CIHAGGRAVL DELEKNLKLT EWHMEPSRMT LYRFGNTSSS SLWYELAYSE
460 470 480 490 500
AKGRIKKGDR IWQIAFGSGF KCNSSVWRAV RSVNPKKEKN PWMDEIHEFP

VEVPKVSTI
Length:509
Mass (Da):57,815
Last modified:June 1, 1998 - v1
Checksum:iDB922BCB2B33662F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003105 Genomic DNA. Translation: AAB95298.1.
CP002685 Genomic DNA. Translation: AEC07869.1.
BT003854 mRNA. Translation: AAO41904.1.
BT005692 mRNA. Translation: AAO64112.1.
PIRiA84663.
RefSeqiNP_180232.1. NM_128221.6.
UniGeneiAt.48521.
At.68413.

Genome annotation databases

EnsemblPlantsiAT2G26640.1; AT2G26640.1; AT2G26640.
GeneIDi817205.
GrameneiAT2G26640.1; AT2G26640.1; AT2G26640.
KEGGiath:AT2G26640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003105 Genomic DNA. Translation: AAB95298.1.
CP002685 Genomic DNA. Translation: AEC07869.1.
BT003854 mRNA. Translation: AAO41904.1.
BT005692 mRNA. Translation: AAO64112.1.
PIRiA84663.
RefSeqiNP_180232.1. NM_128221.6.
UniGeneiAt.48521.
At.68413.

3D structure databases

ProteinModelPortaliO48780.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2557. 1 interactor.
IntActiO48780. 1 interactor.
STRINGi3702.AT2G26640.1.

Proteomic databases

PaxDbiO48780.
PRIDEiO48780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G26640.1; AT2G26640.1; AT2G26640.
GeneIDi817205.
GrameneiAT2G26640.1; AT2G26640.1; AT2G26640.
KEGGiath:AT2G26640.

Organism-specific databases

TAIRiAT2G26640.

Phylogenomic databases

eggNOGiENOG410IHMW. Eukaryota.
ENOG410Y5VH. LUCA.
HOGENOMiHOG000238893.
InParanoidiO48780.
KOiK15397.
OMAiAMVISME.
OrthoDBiEOG093606UZ.
PhylomeDBiO48780.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciARA:AT2G26640-MONOMER.

Miscellaneous databases

PROiO48780.

Gene expression databases

GenevisibleiO48780. AT.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012392. 3-ktacl-CoA_syn.
IPR013747. ACP_syn_III_C.
IPR013601. FAE1_typ3_polyketide_synth.
IPR016039. Thiolase-like.
[Graphical view]
PANTHERiPTHR31561. PTHR31561. 1 hit.
PfamiPF08541. ACP_syn_III_C. 1 hit.
PF08392. FAE1_CUT1_RppA. 1 hit.
[Graphical view]
PIRSFiPIRSF036417. 3-ktacl-CoA_syn. 1 hit.
SUPFAMiSSF53901. SSF53901. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKCS11_ARATH
AccessioniPrimary (citable) accession number: O48780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.