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Protein

Thioredoxin M1, chloroplastic

Gene

At1g03680

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Thiol-disulfide oxidoreductase involved in the redox regulation of enzymes of both reductive pentose phosphate pathway (Calvin-Benson cycle) and oxidative pentose phosphate pathway. Under reducing conditions, activates the glyceraldehyde-3-phosphate dehydrogenase and the phosphoribulokinase, and inhibits. the glucose-6-phosphate dehydrogenase. Activates NADP-malate dehydrogenase.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei98Deprotonates C-terminal active site CysBy similarity1
Active sitei104NucleophileBy similarity1
Sitei105Contributes to redox potential valueBy similarity1
Sitei106Contributes to redox potential valueBy similarity1
Active sitei107NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: GO_Central
  • cellular response to oxidative stress Source: GO_Central
  • glycerol ether metabolic process Source: InterPro
  • negative regulation of catalytic activity Source: UniProtKB
  • oxidation-reduction process Source: GO_Central
  • positive regulation of catalytic activity Source: UniProtKB
  • protein folding Source: GO_Central
  • regulation of carbohydrate metabolic process Source: UniProtKB
  • response to cold Source: TAIR
  • sulfate assimilation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin M1, chloroplastic
Short name:
AtTrxm1
Gene namesi
Ordered Locus Names:At1g03680
ORF Names:F21B7.28, F21B7_7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G03680.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • chloroplast Source: TAIR
  • chloroplast envelope Source: TAIR
  • chloroplast stroma Source: TAIR
  • stromule Source: TAIR
  • thylakoid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48ChloroplastSequence analysisAdd BLAST48
ChainiPRO_000003416249 – 179Thioredoxin M1, chloroplasticAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 107Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO48737.
PRIDEiO48737.

Expressioni

Gene expression databases

GenevisibleiO48737. AT.

Interactioni

Protein-protein interaction databases

BioGridi24671. 3 interactors.
IntActiO48737. 1 interactor.
STRINGi3702.AT1G03680.1.

Structurei

3D structure databases

ProteinModelPortaliO48737.
SMRiO48737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 179ThioredoxinPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0910. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiO48737.
KOiK03671.
OMAiSEMRIAS.
OrthoDBiEOG09360VDR.
PhylomeDBiO48737.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O48737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYTCTSRP PISIRSEMRI ASSPTGSFST RQMFSVLPES SGLRTRVSLS
60 70 80 90 100
SLSKNSRVSR LRRGVICEAQ DTATGIPVVN DSTWDSLVLK ADEPVFVDFW
110 120 130 140 150
APWCGPCKMI DPIVNELAQK YAGQFKFYKL NTDESPATPG QYGVRSIPTI
160 170
MIFVNGEKKD TIIGAVSKDT LATSINKFL
Length:179
Mass (Da):19,665
Last modified:June 1, 1998 - v1
Checksum:i35B9E7C1D132F492
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095749 mRNA. Translation: AAF15948.1.
AC002560 Genomic DNA. Translation: AAF86525.1.
CP002684 Genomic DNA. Translation: AEE27596.1.
BT004295 mRNA. Translation: AAO42293.1.
BT005525 mRNA. Translation: AAO63945.1.
PIRiT00893.
RefSeqiNP_849585.1. NM_179254.7.
UniGeneiAt.20253.

Genome annotation databases

EnsemblPlantsiAT1G03680.1; AT1G03680.1; AT1G03680.
GeneIDi839436.
GrameneiAT1G03680.1; AT1G03680.1; AT1G03680.
KEGGiath:AT1G03680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095749 mRNA. Translation: AAF15948.1.
AC002560 Genomic DNA. Translation: AAF86525.1.
CP002684 Genomic DNA. Translation: AEE27596.1.
BT004295 mRNA. Translation: AAO42293.1.
BT005525 mRNA. Translation: AAO63945.1.
PIRiT00893.
RefSeqiNP_849585.1. NM_179254.7.
UniGeneiAt.20253.

3D structure databases

ProteinModelPortaliO48737.
SMRiO48737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24671. 3 interactors.
IntActiO48737. 1 interactor.
STRINGi3702.AT1G03680.1.

Proteomic databases

PaxDbiO48737.
PRIDEiO48737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G03680.1; AT1G03680.1; AT1G03680.
GeneIDi839436.
GrameneiAT1G03680.1; AT1G03680.1; AT1G03680.
KEGGiath:AT1G03680.

Organism-specific databases

TAIRiAT1G03680.

Phylogenomic databases

eggNOGiKOG0910. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiO48737.
KOiK03671.
OMAiSEMRIAS.
OrthoDBiEOG09360VDR.
PhylomeDBiO48737.

Enzyme and pathway databases

ReactomeiR-ATH-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiO48737.

Gene expression databases

GenevisibleiO48737. AT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXM1_ARATH
AccessioniPrimary (citable) accession number: O48737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.