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O48721

- HEM4_ARATH

UniProt

O48721 - HEM4_ARATH

Protein

Uroporphyrinogen-III synthase, chloroplastic

Gene

UROS

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins.1 Publication

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: UniProtKB

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    3. uroporphyrinogen III biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciARA:AT2G26540-MONOMER.
    MetaCyc:AT2G26540-MONOMER.
    UniPathwayiUPA00251; UER00320.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase, chloroplastic (EC:4.2.1.75)
    Short name:
    AtUROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:UROS
    Synonyms:HEMD
    Ordered Locus Names:At2g26540
    ORF Names:T9J22.21
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G26540.

    Subcellular locationi

    Plastidchloroplast 1 Publication

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 8181ChloroplastSequence AnalysisAdd
    BLAST
    Chaini82 – 321240Uroporphyrinogen-III synthase, chloroplasticPRO_0000376067Add
    BLAST

    Proteomic databases

    PaxDbiO48721.
    PRIDEiO48721.

    Expressioni

    Gene expression databases

    GenevestigatoriO48721.

    Interactioni

    Protein-protein interaction databases

    BioGridi2547. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO48721.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000012769.
    InParanoidiO48721.
    KOiK01719.
    OMAiWIIITSP.
    PhylomeDBiO48721.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O48721-1 [UniParc]FASTAAdd to Basket

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    MALLLLSHCS ILSFQPPLSS SSSFHSSHIQ SLSKPVFASP SPIRNSISSS    50
    VSSSSSSVSS SNSIPQVVVT RERGKNNQII KALEKNGISS LELPLIQHAR 100
    GPDFDRLASV LNDKSFDWII ITSPEAGSVF LEAWKTASSP EVQIGVVGAG 150
    TARVFEEAMK SADGLLHVAF TPSKATGKVL ASELPEKVGK RSSVLYPASL 200
    KAGNDIVEGL SKRGFEVVRL NTYTTVPVQS VDTVLLQQAL SAPVLSVASP 250
    SAVRAWLHLI QNEEQWSNYV ACIGETTASA ARRLGLKNVY YPEKPGLEGW 300
    VESIMEALGA HADSSNPSSR N 321
    Length:321
    Mass (Da):34,225
    Last modified:June 1, 2002 - v2
    Checksum:i747E4E3C2DCEBD08
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291I → V in CAC85287. (PubMed:18042043)Curated
    Sequence conflicti218 – 2181V → I in AAM64811. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ314569 mRNA. Translation: CAC85287.1.
    AC002505 Genomic DNA. Translation: AAC14502.2.
    CP002685 Genomic DNA. Translation: AEC07854.1.
    BT026116 mRNA. Translation: ABG48472.1.
    AY087255 mRNA. Translation: AAM64811.1.
    AY065389 mRNA. Translation: AAL38830.2.
    PIRiT00987.
    RefSeqiNP_565625.1. NM_128211.3.
    UniGeneiAt.28505.

    Genome annotation databases

    EnsemblPlantsiAT2G26540.1; AT2G26540.1; AT2G26540.
    GeneIDi817195.
    KEGGiath:AT2G26540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ314569 mRNA. Translation: CAC85287.1 .
    AC002505 Genomic DNA. Translation: AAC14502.2 .
    CP002685 Genomic DNA. Translation: AEC07854.1 .
    BT026116 mRNA. Translation: ABG48472.1 .
    AY087255 mRNA. Translation: AAM64811.1 .
    AY065389 mRNA. Translation: AAL38830.2 .
    PIRi T00987.
    RefSeqi NP_565625.1. NM_128211.3.
    UniGenei At.28505.

    3D structure databases

    ProteinModelPortali O48721.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 2547. 1 interaction.

    Proteomic databases

    PaxDbi O48721.
    PRIDEi O48721.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G26540.1 ; AT2G26540.1 ; AT2G26540 .
    GeneIDi 817195.
    KEGGi ath:AT2G26540.

    Organism-specific databases

    TAIRi AT2G26540.

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000012769.
    InParanoidi O48721.
    KOi K01719.
    OMAi WIIITSP.
    PhylomeDBi O48721.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .
    UPA00668 .
    BioCyci ARA:AT2G26540-MONOMER.
    MetaCyc:AT2G26540-MONOMER.

    Gene expression databases

    Genevestigatori O48721.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase."
      Tan F.-C., Cheng Q., Saha K., Heinemann I.U., Jahn M., Jahn D., Smith A.G.
      Biochem. J. 410:291-299(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-321.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiHEM4_ARATH
    AccessioniPrimary (citable) accession number: O48721
    Secondary accession number(s): Q8LBE8, Q8RVZ2, Q8VZ12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3