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O48709

- PI5K3_ARATH

UniProt

O48709 - PI5K3_ARATH

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Protein
Phosphatidylinositol 4-phosphate 5-kinase 3
Gene
PIP5K3, At2g26420, T9J22.9
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol phosphorylation Source: GOC
  2. root hair cell tip growth Source: TAIR
  3. root hair elongation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G26420-MONOMER.
ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 3 (EC:2.7.1.68)
Short name:
AtPIP5K3
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 3
Diphosphoinositide kinase 3
PtdIns(4)P-5-kinase 3
Gene namesi
Name:PIP5K3
Ordered Locus Names:At2g26420
ORF Names:T9J22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G26420.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: TAIR
  2. cytoplasm Source: TAIR
  3. plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Phosphatidylinositol 4-phosphate 5-kinase 3
PRO_0000185475Add
BLAST

Proteomic databases

PRIDEiO48709.

Expressioni

Gene expression databases

GenevestigatoriO48709.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G26420.1-P.

Structurei

3D structure databases

ProteinModelPortaliO48709.
SMRiO48709. Positions 379-576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 8023MORN 1
Add
BLAST
Repeati81 – 10323MORN 2
Add
BLAST
Repeati104 – 12623MORN 3
Add
BLAST
Repeati127 – 14923MORN 4
Add
BLAST
Repeati150 – 17223MORN 5
Add
BLAST
Repeati173 – 19523MORN 6
Add
BLAST
Repeati196 – 21823MORN 7
Add
BLAST
Domaini321 – 701381PIPK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni661 – 68222Activation loop By similarity
Add
BLAST

Sequence similaritiesi

Contains 7 MORN repeats.
Contains 1 PIPK domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
InParanoidiO48709.
KOiK00889.
OMAiPRICISE.
PhylomeDBiO48709.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 7 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O48709-1 [UniParc]FASTAAdd to Basket

« Hide

MQETVFLFTE ENLNKEQSLG VKYKQSSRRV VPMTSCEVSD TAAEIRIVEK    50
VLKNGDLYNG GLSAGVPHGT GKYLWSDGCM YEGEWTRGKA SGKGRFSWPS 100
GATYEGQFKD GRMDGEGTFI GIDGDTYRGH WLWGRKHGYG EKRYANGDGY 150
QGNWKANLQD GNGRYVWSDG NEYVGEWKNG VISGKGKMTW ANGNRYDGLW 200
ENGAPVGKGV LSWGEEKTSY NGWGRKSKKK DEEIVQNHKL SSVETLSANT 250
NFPRICISEL EDTGVCDHVE ASPYTSESDT SGCGEQEWAR SPLLLESGGA 300
MSVQQSPRWL DEGDVKKPGH TVTAGHKNYD LMLNLQLGIR YSVGKHASLL 350
RELRHSDFDP KDKQWTRFPP EGSKSTPPHL SAEFKWKDYC PIVFRHLRDL 400
FAIDQADYML AICGNESLRE FASPGKSGSA FYLTQDERYM IKTMKKSEIK 450
VLLKMLPNYY EHVSKYKNSL VTKFFGVHCV KPVGGQKTRF IVMGNLFCSE 500
YRIHKRFDLK GSSHGRTIDK DEGEIDETTT LKDLDLKYVF RLETSWFQAF 550
INQIDLDCEF LEAERIMDYS LLIGLHFRES GMRDDISLGI GRRDQEDKLM 600
RGNGPLMRLG ESTPAKAEQV SRFEEETWEE DAIDNSNPKG TRKEAVEVIL 650
YFGVIDILQD YDITKKLEHA YKSLHADPAS ISAVDPKLYS RRFRDFINKI 700
FIEDK 705
Length:705
Mass (Da):80,134
Last modified:June 1, 1998 - v1
Checksum:i851E86AE18AAF157
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002505 Genomic DNA. Translation: AAC14492.1.
CP002685 Genomic DNA. Translation: AEC07835.1.
PIRiT00975.
RefSeqiNP_180210.1. NM_128199.1.
UniGeneiAt.38897.

Genome annotation databases

EnsemblPlantsiAT2G26420.1; AT2G26420.1; AT2G26420.
GeneIDi817182.
KEGGiath:AT2G26420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002505 Genomic DNA. Translation: AAC14492.1 .
CP002685 Genomic DNA. Translation: AEC07835.1 .
PIRi T00975.
RefSeqi NP_180210.1. NM_128199.1.
UniGenei At.38897.

3D structure databases

ProteinModelPortali O48709.
SMRi O48709. Positions 379-576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G26420.1-P.

Proteomic databases

PRIDEi O48709.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G26420.1 ; AT2G26420.1 ; AT2G26420 .
GeneIDi 817182.
KEGGi ath:AT2G26420.

Organism-specific databases

TAIRi AT2G26420.

Phylogenomic databases

eggNOGi COG4642.
HOGENOMi HOG000193875.
InParanoidi O48709.
KOi K00889.
OMAi PRICISE.
PhylomeDBi O48709.

Enzyme and pathway databases

BioCyci ARA:AT2G26420-MONOMER.
Reactomei REACT_187642. Synthesis of PIPs at the plasma membrane.

Gene expression databases

Genevestigatori O48709.

Family and domain databases

Gene3Di 3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProi IPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view ]
PANTHERi PTHR23086. PTHR23086. 1 hit.
Pfami PF02493. MORN. 7 hits.
PF01504. PIP5K. 1 hit.
[Graphical view ]
PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTi SM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view ]
PROSITEi PS51455. PIPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPI5K3_ARATH
AccessioniPrimary (citable) accession number: O48709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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