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Protein

Phosphatidylinositol 4-phosphate 5-kinase 3

Gene

PIP5K3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  • 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of establishment of cell polarity Source: TAIR
  • root hair cell tip growth Source: TAIR
  • root hair elongation Source: TAIR
  • root hair initiation Source: TAIR

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G26420-MONOMER.
BRENDAi2.7.1.68. 399.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 3 (EC:2.7.1.68)
Short name:
AtPIP5K3
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 3
Diphosphoinositide kinase 3
PtdIns(4)P-5-kinase 3
Gene namesi
Name:PIP5K3
Ordered Locus Names:At2g26420
ORF Names:T9J22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G26420.
TAIRilocus:2066246. AT2G26420.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854751 – 705Phosphatidylinositol 4-phosphate 5-kinase 3Add BLAST705

Proteomic databases

PaxDbiO48709.
PRIDEiO48709.

Expressioni

Gene expression databases

GenevisibleiO48709. AT.

Interactioni

Protein-protein interaction databases

BioGridi2534. 1 interactor.
STRINGi3702.AT2G26420.1.

Structurei

3D structure databases

ProteinModelPortaliO48709.
SMRiO48709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 80MORN 1Add BLAST23
Repeati81 – 103MORN 2Add BLAST23
Repeati104 – 126MORN 3Add BLAST23
Repeati127 – 149MORN 4Add BLAST23
Repeati150 – 172MORN 5Add BLAST23
Repeati173 – 195MORN 6Add BLAST23
Repeati196 – 218MORN 7Add BLAST23
Domaini321 – 701PIPKPROSITE-ProRule annotationAdd BLAST381

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni661 – 682Activation loopBy similarityAdd BLAST22

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JU4R. Eukaryota.
KOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiO48709.
KOiK00889.
OMAiVEVILYF.
OrthoDBiEOG0936025Q.
PhylomeDBiO48709.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiView protein in InterPro
IPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiView protein in Pfam
PF02493. MORN. 7 hits.
PF01504. PIP5K. 1 hit.
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiView protein in SMART
SM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
PROSITEiView protein in PROSITE
PS51455. PIPK. 1 hit.

Sequencei

Sequence statusi: Complete.

O48709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQETVFLFTE ENLNKEQSLG VKYKQSSRRV VPMTSCEVSD TAAEIRIVEK
60 70 80 90 100
VLKNGDLYNG GLSAGVPHGT GKYLWSDGCM YEGEWTRGKA SGKGRFSWPS
110 120 130 140 150
GATYEGQFKD GRMDGEGTFI GIDGDTYRGH WLWGRKHGYG EKRYANGDGY
160 170 180 190 200
QGNWKANLQD GNGRYVWSDG NEYVGEWKNG VISGKGKMTW ANGNRYDGLW
210 220 230 240 250
ENGAPVGKGV LSWGEEKTSY NGWGRKSKKK DEEIVQNHKL SSVETLSANT
260 270 280 290 300
NFPRICISEL EDTGVCDHVE ASPYTSESDT SGCGEQEWAR SPLLLESGGA
310 320 330 340 350
MSVQQSPRWL DEGDVKKPGH TVTAGHKNYD LMLNLQLGIR YSVGKHASLL
360 370 380 390 400
RELRHSDFDP KDKQWTRFPP EGSKSTPPHL SAEFKWKDYC PIVFRHLRDL
410 420 430 440 450
FAIDQADYML AICGNESLRE FASPGKSGSA FYLTQDERYM IKTMKKSEIK
460 470 480 490 500
VLLKMLPNYY EHVSKYKNSL VTKFFGVHCV KPVGGQKTRF IVMGNLFCSE
510 520 530 540 550
YRIHKRFDLK GSSHGRTIDK DEGEIDETTT LKDLDLKYVF RLETSWFQAF
560 570 580 590 600
INQIDLDCEF LEAERIMDYS LLIGLHFRES GMRDDISLGI GRRDQEDKLM
610 620 630 640 650
RGNGPLMRLG ESTPAKAEQV SRFEEETWEE DAIDNSNPKG TRKEAVEVIL
660 670 680 690 700
YFGVIDILQD YDITKKLEHA YKSLHADPAS ISAVDPKLYS RRFRDFINKI

FIEDK
Length:705
Mass (Da):80,134
Last modified:June 1, 1998 - v1
Checksum:i851E86AE18AAF157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002505 Genomic DNA. Translation: AAC14492.1.
CP002685 Genomic DNA. Translation: AEC07835.1.
PIRiT00975.
RefSeqiNP_001318292.1. NM_001336067.1.
UniGeneiAt.38897.

Genome annotation databases

EnsemblPlantsiAT2G26420.1; AT2G26420.1; AT2G26420.
GeneIDi817182.
GrameneiAT2G26420.1; AT2G26420.1; AT2G26420.
KEGGiath:AT2G26420.

Similar proteinsi

Entry informationi

Entry nameiPI5K3_ARATH
AccessioniPrimary (citable) accession number: O48709
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names