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O48709

- PI5K3_ARATH

UniProt

O48709 - PI5K3_ARATH

Protein

Phosphatidylinositol 4-phosphate 5-kinase 3

Gene

PIP5K3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. phosphatidylinositol phosphorylation Source: GOC
    2. root hair cell tip growth Source: TAIR
    3. root hair elongation Source: TAIR

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G26420-MONOMER.
    ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase 3 (EC:2.7.1.68)
    Short name:
    AtPIP5K3
    Alternative name(s):
    1-phosphatidylinositol 4-phosphate kinase 3
    Diphosphoinositide kinase 3
    PtdIns(4)P-5-kinase 3
    Gene namesi
    Name:PIP5K3
    Ordered Locus Names:At2g26420
    ORF Names:T9J22.9
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G26420.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: TAIR
    2. cytoplasm Source: TAIR
    3. plasma membrane Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 705705Phosphatidylinositol 4-phosphate 5-kinase 3PRO_0000185475Add
    BLAST

    Proteomic databases

    PRIDEiO48709.

    Expressioni

    Gene expression databases

    GenevestigatoriO48709.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G26420.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO48709.
    SMRiO48709. Positions 379-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati58 – 8023MORN 1Add
    BLAST
    Repeati81 – 10323MORN 2Add
    BLAST
    Repeati104 – 12623MORN 3Add
    BLAST
    Repeati127 – 14923MORN 4Add
    BLAST
    Repeati150 – 17223MORN 5Add
    BLAST
    Repeati173 – 19523MORN 6Add
    BLAST
    Repeati196 – 21823MORN 7Add
    BLAST
    Domaini321 – 701381PIPKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni661 – 68222Activation loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 7 MORN repeats.Curated
    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG4642.
    HOGENOMiHOG000193875.
    InParanoidiO48709.
    KOiK00889.
    OMAiPRICISE.
    PhylomeDBiO48709.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF02493. MORN. 7 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTiSM00698. MORN. 7 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O48709-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQETVFLFTE ENLNKEQSLG VKYKQSSRRV VPMTSCEVSD TAAEIRIVEK    50
    VLKNGDLYNG GLSAGVPHGT GKYLWSDGCM YEGEWTRGKA SGKGRFSWPS 100
    GATYEGQFKD GRMDGEGTFI GIDGDTYRGH WLWGRKHGYG EKRYANGDGY 150
    QGNWKANLQD GNGRYVWSDG NEYVGEWKNG VISGKGKMTW ANGNRYDGLW 200
    ENGAPVGKGV LSWGEEKTSY NGWGRKSKKK DEEIVQNHKL SSVETLSANT 250
    NFPRICISEL EDTGVCDHVE ASPYTSESDT SGCGEQEWAR SPLLLESGGA 300
    MSVQQSPRWL DEGDVKKPGH TVTAGHKNYD LMLNLQLGIR YSVGKHASLL 350
    RELRHSDFDP KDKQWTRFPP EGSKSTPPHL SAEFKWKDYC PIVFRHLRDL 400
    FAIDQADYML AICGNESLRE FASPGKSGSA FYLTQDERYM IKTMKKSEIK 450
    VLLKMLPNYY EHVSKYKNSL VTKFFGVHCV KPVGGQKTRF IVMGNLFCSE 500
    YRIHKRFDLK GSSHGRTIDK DEGEIDETTT LKDLDLKYVF RLETSWFQAF 550
    INQIDLDCEF LEAERIMDYS LLIGLHFRES GMRDDISLGI GRRDQEDKLM 600
    RGNGPLMRLG ESTPAKAEQV SRFEEETWEE DAIDNSNPKG TRKEAVEVIL 650
    YFGVIDILQD YDITKKLEHA YKSLHADPAS ISAVDPKLYS RRFRDFINKI 700
    FIEDK 705
    Length:705
    Mass (Da):80,134
    Last modified:June 1, 1998 - v1
    Checksum:i851E86AE18AAF157
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002505 Genomic DNA. Translation: AAC14492.1.
    CP002685 Genomic DNA. Translation: AEC07835.1.
    PIRiT00975.
    RefSeqiNP_180210.1. NM_128199.1.
    UniGeneiAt.38897.

    Genome annotation databases

    EnsemblPlantsiAT2G26420.1; AT2G26420.1; AT2G26420.
    GeneIDi817182.
    KEGGiath:AT2G26420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002505 Genomic DNA. Translation: AAC14492.1 .
    CP002685 Genomic DNA. Translation: AEC07835.1 .
    PIRi T00975.
    RefSeqi NP_180210.1. NM_128199.1.
    UniGenei At.38897.

    3D structure databases

    ProteinModelPortali O48709.
    SMRi O48709. Positions 379-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G26420.1-P.

    Proteomic databases

    PRIDEi O48709.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G26420.1 ; AT2G26420.1 ; AT2G26420 .
    GeneIDi 817182.
    KEGGi ath:AT2G26420.

    Organism-specific databases

    TAIRi AT2G26420.

    Phylogenomic databases

    eggNOGi COG4642.
    HOGENOMi HOG000193875.
    InParanoidi O48709.
    KOi K00889.
    OMAi PRICISE.
    PhylomeDBi O48709.

    Enzyme and pathway databases

    BioCyci ARA:AT2G26420-MONOMER.
    Reactomei REACT_187642. Synthesis of PIPs at the plasma membrane.

    Gene expression databases

    Genevestigatori O48709.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF02493. MORN. 7 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTi SM00698. MORN. 7 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
      Mueller-Roeber B., Pical C.
      Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPI5K3_ARATH
    AccessioniPrimary (citable) accession number: O48709
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3