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Protein

Peroxidase 6

Gene

PER6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei58Transition state stabilizerPROSITE-ProRule annotation1
Active sitei62Proton acceptorPROSITE-ProRule annotation1
Metal bindingi63Calcium 1PROSITE-ProRule annotation1
Metal bindingi66Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi68Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi70Calcium 1PROSITE-ProRule annotation1
Metal bindingi72Calcium 1PROSITE-ProRule annotation1
Metal bindingi190Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi191Calcium 2PROSITE-ProRule annotation1
Metal bindingi242Calcium 2PROSITE-ProRule annotation1
Metal bindingi245Calcium 2PROSITE-ProRule annotation1
Metal bindingi250Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei82. AtPrx06.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 6 (EC:1.11.1.7)
Short name:
Atperox P6
Gene namesi
Name:PER6
Synonyms:P6
Ordered Locus Names:At1g24110
ORF Names:F3I6.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G24110.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002367221 – 326Peroxidase 6Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi31 ↔ 112PROSITE-ProRule annotation
Disulfide bondi64 ↔ 69PROSITE-ProRule annotation
Disulfide bondi118 ↔ 318PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi197 ↔ 228PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi230N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO48677.

Expressioni

Gene expression databases

GenevisibleiO48677. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G24110.1.

Structurei

3D structure databases

ProteinModelPortaliO48677.
SMRiO48677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH5P. Eukaryota.
ENOG410YA7M. LUCA.
HOGENOMiHOG000237556.
InParanoidiO48677.
KOiK00430.
OMAiRKLCANY.
OrthoDBiEOG09360HTJ.
PhylomeDBiO48677.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O48677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFGLCLFI LVSSPCLLQA NLSSDYYTKT CPEFEETLVQ IVTDKQIAAP
60 70 80 90 100
TTAVGTLRLF FHDCMVDGCD ASILVASTPR KTSERDADIN RSLPGDAFDV
110 120 130 140 150
ITRIKTAVEL KCPNIVSCSD ILVGATRSLI SMVGGPRVNV KFGRKDSLVS
160 170 180 190 200
DMNRVEGKLA RPNMTMDHII SIFESSGLTV QEMVALVGAH TIGFSHCKEF
210 220 230 240 250
ASRIFNKSDQ NGPVEMNPKY AAELRKLCAN YTNDEQMSAF NDVFTPGKFD
260 270 280 290 300
NMYYKNLKHG YGLLQSDHAI AFDNRTRSLV DLYAEDETAF FDAFAKAMEK
310 320
VSEKNVKTGK LGEVRRRCDQ YNDYKG
Length:326
Mass (Da):36,253
Last modified:June 1, 1998 - v1
Checksum:i38363A08266EAEAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002396 Genomic DNA. Translation: AAC00571.1.
CP002684 Genomic DNA. Translation: AEE30479.1.
DQ056462 mRNA. Translation: AAY78619.1.
PIRiT00640.
RefSeqiNP_173821.1. NM_102257.2.
UniGeneiAt.51747.

Genome annotation databases

EnsemblPlantsiAT1G24110.1; AT1G24110.1; AT1G24110.
GeneIDi839023.
GrameneiAT1G24110.1; AT1G24110.1; AT1G24110.
KEGGiath:AT1G24110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002396 Genomic DNA. Translation: AAC00571.1.
CP002684 Genomic DNA. Translation: AEE30479.1.
DQ056462 mRNA. Translation: AAY78619.1.
PIRiT00640.
RefSeqiNP_173821.1. NM_102257.2.
UniGeneiAt.51747.

3D structure databases

ProteinModelPortaliO48677.
SMRiO48677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G24110.1.

Protein family/group databases

PeroxiBasei82. AtPrx06.

Proteomic databases

PaxDbiO48677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G24110.1; AT1G24110.1; AT1G24110.
GeneIDi839023.
GrameneiAT1G24110.1; AT1G24110.1; AT1G24110.
KEGGiath:AT1G24110.

Organism-specific databases

TAIRiAT1G24110.

Phylogenomic databases

eggNOGiENOG410IH5P. Eukaryota.
ENOG410YA7M. LUCA.
HOGENOMiHOG000237556.
InParanoidiO48677.
KOiK00430.
OMAiRKLCANY.
OrthoDBiEOG09360HTJ.
PhylomeDBiO48677.

Miscellaneous databases

PROiO48677.

Gene expression databases

GenevisibleiO48677. AT.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER6_ARATH
AccessioniPrimary (citable) accession number: O48677
Secondary accession number(s): Q4PT24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.