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O48646

- GPX6_ARATH

UniProt

O48646 - GPX6_ARATH

Protein

Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial

Gene

GPX6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.By similarity

    Catalytic activityi

    2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051By similarity

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: TAIR
    2. phospholipid-hydroperoxide glutathione peroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to cadmium ion Source: TAIR
    2. response to oxidative stress Source: InterPro
    3. response to salt stress Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Stress response

    Protein family/group databases

    PeroxiBasei2502. AtGPx06.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial (EC:1.11.1.12)
    Short name:
    AtGPX1
    Short name:
    PHGPx
    Gene namesi
    Name:GPX6
    Synonyms:GPX1
    Ordered Locus Names:At4g11600
    ORF Names:T5C23.30
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G11600.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: TAIR
    2. chloroplast Source: TAIR
    3. cytosol Source: TAIR
    4. mitochondrion Source: TAIR
    5. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5454MitochondrionSequence AnalysisAdd
    BLAST
    Chaini55 – 232178Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrialPRO_0000013088Add
    BLAST

    Proteomic databases

    PaxDbiO48646.
    PRIDEiO48646.

    Expressioni

    Tissue specificityi

    Expressed at a low but detectable level in leaves, stems, and flowers, but at a higher level in siliques and even higher in roots. Predominantly expressed in seeds.2 Publications

    Inductioni

    By salt stress, osmotic stress, cold treatment, and metals. Up-regulated by salicylic acid (SA), jasmonic acid (JA), abscisic acid (ABA) and auxin.3 Publications

    Gene expression databases

    GenevestigatoriO48646.

    Interactioni

    Protein-protein interaction databases

    BioGridi12064. 1 interaction.
    IntActiO48646. 2 interactions.
    STRINGi3702.AT4G11600.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO48646.
    SMRiO48646. Positions 71-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutathione peroxidase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0386.
    HOGENOMiHOG000277054.
    InParanoidiO48646.
    KOiK00432.
    OMAiRFAPLTK.
    PhylomeDBiO48646.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11592. PTHR11592. 1 hit.
    PfamiPF00255. GSHPx. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
    PRINTSiPR01011. GLUTPROXDASE.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O48646-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRSSIRLLY IRRTSPLLRS LSSSSSSSSS KRFDSAKPLF NSHRIISLPI    50
    STTGAKLSRS EHSMAASSEP KSLYDFTVKD AKGNDVDLSI YKGKVLLIVN 100
    VASQCGLTNS NYTELAQLYE KYKGHGFEIL AFPCNQFGNQ EPGTNEEIVQ 150
    FACTRFKAEY PIFDKVDVNG DKAAPVYKFL KSSKGGLFGD GIKWNFAKFL 200
    VDKDGNVVDR FAPTTSPLSI EKDVKKLLGV TA 232
    Length:232
    Mass (Da):25,584
    Last modified:May 10, 2004 - v2
    Checksum:i93F3084A8A331494
    GO

    Sequence cautioni

    The sequence AAC09173.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAM66969.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA24226.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB39931.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB78203.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301S → SSSS1 PublicationCurated
    Sequence conflicti51 – 511S → Y(PubMed:9511228)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030132 mRNA. Translation: AAC09173.1. Different initiation.
    AL049500 Genomic DNA. Translation: CAB39931.1. Different initiation.
    AL161532 Genomic DNA. Translation: CAB78203.1. Different initiation.
    CP002687 Genomic DNA. Translation: AEE83029.1.
    AY039863 mRNA. Translation: AAK63967.1.
    AY077655 mRNA. Translation: AAL76133.1.
    AY088647 mRNA. Translation: AAM66969.1. Different initiation.
    AB001568 mRNA. Translation: BAA24226.1. Different initiation.
    PIRiT04207.
    RefSeqiNP_192897.2. NM_117229.3.
    UniGeneiAt.23184.

    Genome annotation databases

    EnsemblPlantsiAT4G11600.1; AT4G11600.1; AT4G11600.
    GeneIDi826765.
    KEGGiath:AT4G11600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030132 mRNA. Translation: AAC09173.1 . Different initiation.
    AL049500 Genomic DNA. Translation: CAB39931.1 . Different initiation.
    AL161532 Genomic DNA. Translation: CAB78203.1 . Different initiation.
    CP002687 Genomic DNA. Translation: AEE83029.1 .
    AY039863 mRNA. Translation: AAK63967.1 .
    AY077655 mRNA. Translation: AAL76133.1 .
    AY088647 mRNA. Translation: AAM66969.1 . Different initiation.
    AB001568 mRNA. Translation: BAA24226.1 . Different initiation.
    PIRi T04207.
    RefSeqi NP_192897.2. NM_117229.3.
    UniGenei At.23184.

    3D structure databases

    ProteinModelPortali O48646.
    SMRi O48646. Positions 71-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 12064. 1 interaction.
    IntActi O48646. 2 interactions.
    STRINGi 3702.AT4G11600.1-P.

    Protein family/group databases

    PeroxiBasei 2502. AtGPx06.

    Proteomic databases

    PaxDbi O48646.
    PRIDEi O48646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G11600.1 ; AT4G11600.1 ; AT4G11600 .
    GeneIDi 826765.
    KEGGi ath:AT4G11600.

    Organism-specific databases

    GeneFarmi 2055. 163.
    TAIRi AT4G11600.

    Phylogenomic databases

    eggNOGi COG0386.
    HOGENOMi HOG000277054.
    InParanoidi O48646.
    KOi K00432.
    OMAi RFAPLTK.
    PhylomeDBi O48646.

    Gene expression databases

    Genevestigatori O48646.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11592. PTHR11592. 1 hit.
    Pfami PF00255. GSHPx. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
    PRINTSi PR01011. GLUTPROXDASE.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cDNA encoding a putative glutathione peroxidase protein from Arabidopsis thaliana."
      Bilodeau P., Luo M., Dennis E.S., Peacock W.J., Chaudhury A.M.
      Plant Gene Register PGR98-047
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: cv. Landsberg erecta.
    2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-232.
    6. "Putative phospholipid hydroperoxide glutathione peroxidase gene from Arabidopsis thaliana induced by oxidative stress."
      Sugimoto M., Sakamoto W.
      Genes Genet. Syst. 72:311-316(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-232, INDUCTION.
      Strain: cv. Columbia.
    7. "Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways."
      Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P.
      Plant J. 36:602-615(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiGPX6_ARATH
    AccessioniPrimary (citable) accession number: O48646
    Secondary accession number(s): Q94BV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3