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O48646

- GPX6_ARATH

UniProt

O48646 - GPX6_ARATH

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Protein

Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial

Gene

GPX6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.By similarity

Catalytic activityi

2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051By similarity

GO - Molecular functioni

  1. glutathione peroxidase activity Source: TAIR
  2. phospholipid-hydroperoxide glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to cadmium ion Source: TAIR
  2. response to oxidative stress Source: InterPro
  3. response to salt stress Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Stress response

Protein family/group databases

PeroxiBasei2502. AtGPx06.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial (EC:1.11.1.12)
Short name:
AtGPX1
Short name:
PHGPx
Gene namesi
Name:GPX6
Synonyms:GPX1
Ordered Locus Names:At4g11600
ORF Names:T5C23.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G11600.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. chloroplast Source: TAIR
  3. cytosol Source: TAIR
  4. mitochondrion Source: TAIR
  5. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5454MitochondrionSequence AnalysisAdd
BLAST
Chaini55 – 232178Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrialPRO_0000013088Add
BLAST

Proteomic databases

PaxDbiO48646.
PRIDEiO48646.

Expressioni

Tissue specificityi

Expressed at a low but detectable level in leaves, stems, and flowers, but at a higher level in siliques and even higher in roots. Predominantly expressed in seeds.2 Publications

Inductioni

By salt stress, osmotic stress, cold treatment, and metals. Up-regulated by salicylic acid (SA), jasmonic acid (JA), abscisic acid (ABA) and auxin.3 Publications

Gene expression databases

GenevestigatoriO48646.

Interactioni

Protein-protein interaction databases

BioGridi12064. 1 interaction.
IntActiO48646. 2 interactions.
STRINGi3702.AT4G11600.1-P.

Structurei

3D structure databases

ProteinModelPortaliO48646.
SMRiO48646. Positions 71-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0386.
HOGENOMiHOG000277054.
InParanoidiO48646.
KOiK00432.
OMAiRFAPLTK.
PhylomeDBiO48646.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O48646-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRSSIRLLY IRRTSPLLRS LSSSSSSSSS KRFDSAKPLF NSHRIISLPI
60 70 80 90 100
STTGAKLSRS EHSMAASSEP KSLYDFTVKD AKGNDVDLSI YKGKVLLIVN
110 120 130 140 150
VASQCGLTNS NYTELAQLYE KYKGHGFEIL AFPCNQFGNQ EPGTNEEIVQ
160 170 180 190 200
FACTRFKAEY PIFDKVDVNG DKAAPVYKFL KSSKGGLFGD GIKWNFAKFL
210 220 230
VDKDGNVVDR FAPTTSPLSI EKDVKKLLGV TA
Length:232
Mass (Da):25,584
Last modified:May 10, 2004 - v2
Checksum:i93F3084A8A331494
GO

Sequence cautioni

The sequence AAC09173.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAM66969.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA24226.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB39931.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB78203.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301S → SSSS1 PublicationCurated
Sequence conflicti51 – 511S → Y(PubMed:9511228)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030132 mRNA. Translation: AAC09173.1. Different initiation.
AL049500 Genomic DNA. Translation: CAB39931.1. Different initiation.
AL161532 Genomic DNA. Translation: CAB78203.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE83029.1.
AY039863 mRNA. Translation: AAK63967.1.
AY077655 mRNA. Translation: AAL76133.1.
AY088647 mRNA. Translation: AAM66969.1. Different initiation.
AB001568 mRNA. Translation: BAA24226.1. Different initiation.
PIRiT04207.
RefSeqiNP_192897.2. NM_117229.3.
UniGeneiAt.23184.

Genome annotation databases

EnsemblPlantsiAT4G11600.1; AT4G11600.1; AT4G11600.
GeneIDi826765.
KEGGiath:AT4G11600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030132 mRNA. Translation: AAC09173.1 . Different initiation.
AL049500 Genomic DNA. Translation: CAB39931.1 . Different initiation.
AL161532 Genomic DNA. Translation: CAB78203.1 . Different initiation.
CP002687 Genomic DNA. Translation: AEE83029.1 .
AY039863 mRNA. Translation: AAK63967.1 .
AY077655 mRNA. Translation: AAL76133.1 .
AY088647 mRNA. Translation: AAM66969.1 . Different initiation.
AB001568 mRNA. Translation: BAA24226.1 . Different initiation.
PIRi T04207.
RefSeqi NP_192897.2. NM_117229.3.
UniGenei At.23184.

3D structure databases

ProteinModelPortali O48646.
SMRi O48646. Positions 71-230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 12064. 1 interaction.
IntActi O48646. 2 interactions.
STRINGi 3702.AT4G11600.1-P.

Protein family/group databases

PeroxiBasei 2502. AtGPx06.

Proteomic databases

PaxDbi O48646.
PRIDEi O48646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G11600.1 ; AT4G11600.1 ; AT4G11600 .
GeneIDi 826765.
KEGGi ath:AT4G11600.

Organism-specific databases

GeneFarmi 2055. 163.
TAIRi AT4G11600.

Phylogenomic databases

eggNOGi COG0386.
HOGENOMi HOG000277054.
InParanoidi O48646.
KOi K00432.
OMAi RFAPLTK.
PhylomeDBi O48646.

Gene expression databases

Genevestigatori O48646.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a cDNA encoding a putative glutathione peroxidase protein from Arabidopsis thaliana."
    Bilodeau P., Luo M., Dennis E.S., Peacock W.J., Chaudhury A.M.
    Plant Gene Register PGR98-047
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Landsberg erecta.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-232.
  6. "Putative phospholipid hydroperoxide glutathione peroxidase gene from Arabidopsis thaliana induced by oxidative stress."
    Sugimoto M., Sakamoto W.
    Genes Genet. Syst. 72:311-316(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-232, INDUCTION.
    Strain: cv. Columbia.
  7. "Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways."
    Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P.
    Plant J. 36:602-615(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiGPX6_ARATH
AccessioniPrimary (citable) accession number: O48646
Secondary accession number(s): Q94BV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3