ID   HPPD_HORVU              Reviewed;         434 AA.
AC   O48604;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            EC=1.13.11.27;
DE   AltName: Full=4-hydroxyphenylpyruvic acid oxidase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Pooideae; Triticeae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Carina; TISSUE=Meristem;
RA   Krupinska K., Falk J.;
RT   "cDNA sequence encoding a barley 4-hydroxyphenylpyruvate dioxygenase
RT   with enhanced expression in meristematic leaf tissue and during leaf
RT   senescence.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- PATHWAY: Cofactor biosynthesis; prenylquinone biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; AJ000693; CAA04245.1; -; mRNA.
DR   PIR; T04471; T04471.
DR   SMR; O48604; 28-424.
DR   Gramene; O48604; -.
DR   BRENDA; 1.13.11.27; 283.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    434       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088399.
FT   METAL       211    211       Iron (By similarity).
FT   METAL       293    293       Iron (By similarity).
FT   METAL       379    379       Iron (By similarity).
SQ   SEQUENCE   434 AA;  46550 MW;  42DE721182654A4C CRC64;
     MPPTPTTPAA TGAAAAVTPE HARPHRMVRF NPRSDRFHTL SFHHVEFWCA DAASAAGRFA
     FALGAPLAAR SDLSTGNSAH ASQLLRSGSL AFLFTAPYAN GCDAATASLP SFSADAARRF
     SADHGIAVRS VALRVADAAE AFRASRRRGA RPAFAPVDLG RGFAFAEVEL YGDVVLRFVS
     HPDGTDVPFL PGFEGVTNPD AVDYGLTRFD HVVGNVPELA PAAAYIAGFT GFHEFAEFTA
     EDVGTTESGL NSVVLANNSE GVLLPLNEPV HGTKRRSQIQ TFLEHHGGPG VQHIAVASSD
     VLRTLRKMRA RSAMGGFDFL PPPLPKYYEG VRRLAGDVLS EAQIKECQEL GVLVDRDDQG
     VLLQIFTKPV GDRPTLFLEM IQRIGCMEKD ERGEEYQKGG CGGFGKGNFS ELFKSIEDYE
     KSLEAKQSAA VQGS
//