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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Pathwayi: prenylquinone biosynthesis

This protein is involved in the pathway prenylquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway prenylquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi211 – 2111IronBy similarity
Metal bindingi293 – 2931IronBy similarity
Metal bindingi379 – 3791IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.27. 2687.
UniPathwayiUPA00139; UER00362.
UPA00975.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4344344-hydroxyphenylpyruvate dioxygenasePRO_0000088399Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4513.MLOC_55337.1.

Structurei

3D structure databases

ProteinModelPortaliO48604.
SMRiO48604. Positions 28-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Phylogenomic databases

eggNOGiKOG0638. Eukaryota.
COG3185. LUCA.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

Sequencei

Sequence statusi: Complete.

O48604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPTPTTPAA TGAAAAVTPE HARPHRMVRF NPRSDRFHTL SFHHVEFWCA
60 70 80 90 100
DAASAAGRFA FALGAPLAAR SDLSTGNSAH ASQLLRSGSL AFLFTAPYAN
110 120 130 140 150
GCDAATASLP SFSADAARRF SADHGIAVRS VALRVADAAE AFRASRRRGA
160 170 180 190 200
RPAFAPVDLG RGFAFAEVEL YGDVVLRFVS HPDGTDVPFL PGFEGVTNPD
210 220 230 240 250
AVDYGLTRFD HVVGNVPELA PAAAYIAGFT GFHEFAEFTA EDVGTTESGL
260 270 280 290 300
NSVVLANNSE GVLLPLNEPV HGTKRRSQIQ TFLEHHGGPG VQHIAVASSD
310 320 330 340 350
VLRTLRKMRA RSAMGGFDFL PPPLPKYYEG VRRLAGDVLS EAQIKECQEL
360 370 380 390 400
GVLVDRDDQG VLLQIFTKPV GDRPTLFLEM IQRIGCMEKD ERGEEYQKGG
410 420 430
CGGFGKGNFS ELFKSIEDYE KSLEAKQSAA VQGS
Length:434
Mass (Da):46,550
Last modified:June 1, 1998 - v1
Checksum:i42DE721182654A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000693 mRNA. Translation: CAA04245.1.
PIRiT04471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000693 mRNA. Translation: CAA04245.1.
PIRiT04471.

3D structure databases

ProteinModelPortaliO48604.
SMRiO48604. Positions 28-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4513.MLOC_55337.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0638. Eukaryota.
COG3185. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00362.
UPA00975.
BRENDAi1.13.11.27. 2687.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHPPD_HORVU
AccessioniPrimary (citable) accession number: O48604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: February 17, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.