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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Pathwayi: prenylquinone biosynthesis

This protein is involved in the pathway prenylquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway prenylquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi211IronBy similarity1
Metal bindingi293IronBy similarity1
Metal bindingi379IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.27 2687
UniPathwayiUPA00139; UER00362
UPA00975

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000883991 – 4344-hydroxyphenylpyruvate dioxygenaseAdd BLAST434

Proteomic databases

PRIDEiO48604

Expressioni

Gene expression databases

ExpressionAtlasiO48604 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliO48604
SMRiO48604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 192VOC 1PROSITE-ProRule annotationAdd BLAST152
Domaini208 – 368VOC 2PROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0638 Eukaryota
COG3185 LUCA

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR005956 4OHPhenylPyrv_dOase
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PANTHERiPTHR11959 PTHR11959, 1 hit
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
PIRSFiPIRSF009283 HPP_dOase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR01263 4HPPD, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

Sequencei

Sequence statusi: Complete.

O48604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPTPTTPAA TGAAAAVTPE HARPHRMVRF NPRSDRFHTL SFHHVEFWCA
60 70 80 90 100
DAASAAGRFA FALGAPLAAR SDLSTGNSAH ASQLLRSGSL AFLFTAPYAN
110 120 130 140 150
GCDAATASLP SFSADAARRF SADHGIAVRS VALRVADAAE AFRASRRRGA
160 170 180 190 200
RPAFAPVDLG RGFAFAEVEL YGDVVLRFVS HPDGTDVPFL PGFEGVTNPD
210 220 230 240 250
AVDYGLTRFD HVVGNVPELA PAAAYIAGFT GFHEFAEFTA EDVGTTESGL
260 270 280 290 300
NSVVLANNSE GVLLPLNEPV HGTKRRSQIQ TFLEHHGGPG VQHIAVASSD
310 320 330 340 350
VLRTLRKMRA RSAMGGFDFL PPPLPKYYEG VRRLAGDVLS EAQIKECQEL
360 370 380 390 400
GVLVDRDDQG VLLQIFTKPV GDRPTLFLEM IQRIGCMEKD ERGEEYQKGG
410 420 430
CGGFGKGNFS ELFKSIEDYE KSLEAKQSAA VQGS
Length:434
Mass (Da):46,550
Last modified:June 1, 1998 - v1
Checksum:i42DE721182654A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000693 mRNA Translation: CAA04245.1
PIRiT04471

Similar proteinsi

Entry informationi

Entry nameiHPPD_HORVU
AccessioniPrimary (citable) accession number: O48604
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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