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O48593 (SYNO_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Asparagine--tRNA ligase, chloroplastic/mitochondrial
EC=6.1.1.22
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS
Gene names
Name:SYNO
Synonyms:NS1
Ordered Locus Names:At4g17300
ORF Names:dl4685w
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

Subcellular location

Plastid › chloroplast. Mitochondrion Ref.5.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Sequence caution

The sequence CAB10511.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAB78733.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Chloroplast and mitochondrion Potential
Chain? – 567Asparagine--tRNA ligase, chloroplastic/mitochondrialPRO_0000035800

Experimental info

Sequence conflict2791N → Y in CAA10904. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O48593 [UniParc].

Last modified November 9, 2004. Version 3.
Checksum: D5CAE4EBB7780264

FASTA56763,698
        10         20         30         40         50         60 
MAATFLPATS LRLTQNSTLR FLSFFTISNP SYSLFRPLRR RVLPPFDAFP ANSRRRCFCT 

        70         80         90        100        110        120 
AVSESLGSGD GNKVESYEKR FGSKVGEFRK KLRIAEVKGG ADEGLSRVGQ SLNIMGWVRT 

       130        140        150        160        170        180 
LRSQSSVTFI EINDGSCLSN LQCVMTSDAE GYDQVESGSI LTGASVSVQG TIVASQGTKQ 

       190        200        210        220        230        240 
KVELKVEKII VVGECDSSYP IQKKRVSREF LRTKAHLRPR TNTFGAVARV RNTLAYATHK 

       250        260        270        280        290        300 
FFQESGFVWV ASPIITASDC EGAGEQFCVT TLIPSSHENT DTSIDAIPKT KGGLIDWSQD 

       310        320        330        340        350        360 
FFGKPAFLTV SGQLNGETYA TALSDVYTFG PTFRAENSNT SRHLAEFWMI EPELAFADLD 

       370        380        390        400        410        420 
DDMACATAYL QYVVKYVLDN CKEDMEFFDT WIEKGIIRRL SDVAEKEFLQ LGYTDAIEIL 

       430        440        450        460        470        480 
LKANKKFDFP VKWGLDLQSE HERYITEEAF GGRPVIIRDY PKEIKAFYMR ENDDGKTVAA 

       490        500        510        520        530        540 
MDMLVPRIGE LIGGSQREER LEVLEARLDE LKLNKESYWW YLDLRRYGSV PHAGFGLGFE 

       550        560 
RLVQFVTGID NIRDVIPFPR TPASAEF

« Hide

References

« Hide 'large scale' references
[1]"Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana."
Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E. expand/collapse author list , Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.
Nature 391:485-488(1998) [PubMed: 9461215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. expand/collapse author list , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
Nature 402:769-777(1999) [PubMed: 10617198] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Structure and expression of an asparaginyl-tRNA synthetase gene located on chromosome IV of Arabidopsis thaliana and adjacent to a novel large gene of 15 exons."
Aubourg S., Cheron A., Kreis M., Lecharny A.
Biochim. Biophys. Acta 1398:225-231(1998) [PubMed: 9655910] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-566.
Strain: cv. Columbia.
[5]"Duplication and quadruplication of Arabidopsis thaliana cysteinyl- and asparaginyl-tRNA synthetase genes of organellar origin."
Peeters N.M., Chapron A., Giritch A., Grandjean O., Lancelin D., Lhomme T., Vivrel A., Small I.
J. Mol. Evol. 50:413-423(2000) [PubMed: 10824085] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z97343 Genomic DNA. Translation: CAB10511.1. Sequence problems.
AL161546 Genomic DNA. Translation: CAB78733.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83874.1.
AJ222644 mRNA. Translation: CAA10904.1.
IPIIPI00530771.
RefSeqNP_193462.1. NM_117835.4.
UniGeneAt.123.
At.26556.

3D structure databases

ProteinModelPortalO48593.
SMRO48593. Positions 105-566.
ModBaseSearch...

Protein-protein interaction databases

STRINGO48593.

Proteomic databases

PRIDEO48593.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT4G17300.1; AT4G17300.1; AT4G17300.
GeneID827443.
GenomeReviewsGene locus AT4G17300 in contig CT486007_GR.
KEGGath:AT4G17300.

Organism-specific databases

GeneFarm2406. 269.
TAIRAt4g17300.

Phylogenomic databases

eggNOGKOG0554.
HOGENOMHBG745843.
InParanoidO48593.
OMAAIHRFFH.
PhylomeDBO48593.
ProtClustDBPLN02603.

Gene expression databases

ArrayExpressO48593.
GenevestigatorO48593.
GermOnlineAT4G17300. Arabidopsis thaliana.

Family and domain databases

InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-synth_IIb.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR004365. NA-bd_OB_tRNA-helicase.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK01893.
PANTHERPTHR22594. aa-tRNA-synt_II. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PRINTSPR01042. TRNASYNTHASP.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00457. AsnS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYNO_ARATH
AccessionPrimary (citable) accession number: O48593
Secondary accession number(s): O23573
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 9, 2004
Last modified: January 25, 2012
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents