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Protein

Disease resistance protein LAZ5

Gene

LAZ5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TIR-NB-LRR receptor-like protein that may play a role in plant innate immunity. May trigger hypersensitive programmed cell death in response to pathogen attack (PubMed:20949080). Involved in tolerance to tobacco ringspot virus (TRSV) (PubMed:22057987).2 Publications

GO - Molecular functioni

GO - Biological processi

  • defense response to virus Source: TAIR
  • plant-type hypersensitive response Source: TAIR
  • response to virus Source: TAIR
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Plant defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Disease resistance protein LAZ5Curated
Alternative name(s):
Protein LAZARUS 51 Publication
Protein TOLERANCE TO TOBACCO RINGSPOT VIRUS 11 Publication
Gene namesi
Name:LAZ51 Publication
Synonyms:TTR11 Publication
Ordered Locus Names:At5g44870Imported
ORF Names:K21C13.4Imported, T19K24.2Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G44870.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi287 – 2871I → N in laz5-D2; dominant negative mutation responsible for suppression of the acd11-dependent autoimmune response. 1 Publication
Mutagenesisi811 – 8111G → E in laz5-D3; dominant negative mutation responsible for suppression of the acd11-dependent autoimmune response. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11701170Disease resistance protein LAZ5PRO_0000433383Add
BLAST

Proteomic databases

PaxDbiO48573.
PRIDEiO48573.

Expressioni

Inductioni

Up-regulated by ASHH2 via epigenetic chromatin H3K36me3 regulation during the vegetative development.1 Publication

Gene expression databases

GenevisibleiO48573. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G44870.1.

Structurei

3D structure databases

ProteinModelPortaliO48573.
SMRiO48573. Positions 13-172, 279-310, 698-915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 146137TIRPROSITE-ProRule annotationAdd
BLAST
Domaini261 – 513253NB-ARCSequence analysisAdd
BLAST
Repeati595 – 61622LRR 1Sequence analysisAdd
BLAST
Repeati622 – 64524LRR 2Sequence analysisAdd
BLAST
Repeati646 – 67025LRR 3Sequence analysisAdd
BLAST
Repeati677 – 70024LRR 4Sequence analysisAdd
BLAST
Repeati723 – 74725LRR 5Sequence analysisAdd
BLAST
Repeati761 – 78525LRR 6Sequence analysisAdd
BLAST
Repeati790 – 81324LRR 7Sequence analysisAdd
BLAST
Repeati815 – 83723LRR 8Sequence analysisAdd
BLAST
Repeati838 – 86124LRR 9Sequence analysisAdd
BLAST
Repeati862 – 88524LRR 10Sequence analysisAdd
BLAST
Repeati888 – 90417LRR 11Sequence analysisAdd
BLAST
Repeati905 – 93026LRR 12Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 NB-ARC domain.Sequence analysis
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886. LUCA.
HOGENOMiHOG000064702.
InParanoidiO48573.
OMAiYGCERLE.
PhylomeDBiO48573.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF07725. LRR_3. 1 hit.
PF00931. NB-ARC. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O48573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSEILPE SWQVFINFRG ADLRNGFISH LAGALTSAGI TYYIDTEEVP
60 70 80 90 100
SEDLTVLFKR IEESEIALSI FSSNYAESKW CLDELVKIME QVKKGKLRIM
110 120 130 140 150
PVFFNVKPEE VREQNGEFGL KLYGEGKSKR PNIPNWENAL RSVPSKIGLN
160 170 180 190 200
LANFRNEKEL LDKIIDSIKK VLARITRASR VAESLNGISK DSEAKNVDTF
210 220 230 240 250
SPNSSDFPST SIDDDLSINS PQYQATIPPA SREGERLNTI STVSSTGSIE
260 270 280 290 300
HPPPNYGIEP RLKEMEEKLD FDSLETKTVG IVGMPGIGKT TLAETLYRKW
310 320 330 340 350
EHKFERSMFF PDASKMANEH GMCWLQKRLL EELLKDTNLN IGYTTNEHEF
360 370 380 390 400
CKDVLLLKKV FLVIDNVSSE EQIETLFGKW NWIKNGSKIV ITSSDESMLK
410 420 430 440 450
GFVKDTYVVP SLNSRDSLLW FTNHAFGLDD AQGNLVKLSK HFLNYAKGNP
460 470 480 490 500
LALGAFGVEL CGKDKADWEK RIKTLTLISN KMIQDVLRRR YDELTERQKD
510 520 530 540 550
IFLDVACFFK SENESYVRHV VNSCDSESTK SWDEITDLKG KFLVNISGGR
560 570 580 590 600
VEMHDILCTF AKELASQALT EDTRVHLRLW NYQDIMWFLN NELEMENVRG
610 620 630 640 650
IFLDMSKVPE EMTFDGNIFS NMCNLRYLKI YSSVCHKEGE GIFKFDTVRE
660 670 680 690 700
IQLPLDKVRY LHWMKYPWEK LPSDFNPENL VDLELPYSSI KKVWEGVKDT
710 720 730 740 750
PILKWANLSY SSKLTNLLGL SNAKNLERLN LEGCTSLLKL PQEMENMKSL
760 770 780 790 800
VFLNMRRCTS LTCLQSIKVS SLKILILSDC SKLEEFEVIS ENLEELYLDG
810 820 830 840 850
TAIKGLPPAA GDLTRLVVLN MEGCTELESL PKRLGKQKAL QELVLSGCSK
860 870 880 890 900
LESVPTDVKD MKHLRLLLLD GTRIRKIPKI KSLKCLCLSR NIAMVNLQDN
910 920 930 940 950
LKDFSNLKCL VMKNCENLRY LPSLPKCLEY LNVYGCERLE SVENPLVADR
960 970 980 990 1000
LTLFLDRSEE LRSTFLFTNC HNLFQDAKDS ISTYAKWKCH RLAVECYEQD
1010 1020 1030 1040 1050
IVSGAFFNTC YPGYIVPSWF DHQAVGSVLE PRLEPHWYNT MLSGIALCAV
1060 1070 1080 1090 1100
VSFHENQDPI IGSFSVKCTL QFENEDGSLR FDCDIGCLNE PGMIEADHVF
1110 1120 1130 1140 1150
IGYVTCSRLK DHHSIPIHHP TTVKMQFHLT DACKSKVVDC GFRLMYTQSR
1160 1170
GCLLEEEVNA NFTKLYLGLL
Length:1,170
Mass (Da):133,398
Last modified:June 1, 1998 - v1
Checksum:i16DD3292DB9ED589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010693 Genomic DNA. Translation: BAB10868.1.
AC002342 Genomic DNA. Translation: AAC79134.1.
CP002688 Genomic DNA. Translation: AED95170.1.
RefSeqiNP_199300.1. NM_123855.1.
UniGeneiAt.55368.

Genome annotation databases

EnsemblPlantsiAT5G44870.1; AT5G44870.1; AT5G44870.
GeneIDi834517.
GrameneiAT5G44870.1; AT5G44870.1; AT5G44870.
KEGGiath:AT5G44870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010693 Genomic DNA. Translation: BAB10868.1.
AC002342 Genomic DNA. Translation: AAC79134.1.
CP002688 Genomic DNA. Translation: AED95170.1.
RefSeqiNP_199300.1. NM_123855.1.
UniGeneiAt.55368.

3D structure databases

ProteinModelPortaliO48573.
SMRiO48573. Positions 13-172, 279-310, 698-915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G44870.1.

Proteomic databases

PaxDbiO48573.
PRIDEiO48573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G44870.1; AT5G44870.1; AT5G44870.
GeneIDi834517.
GrameneiAT5G44870.1; AT5G44870.1; AT5G44870.
KEGGiath:AT5G44870.

Organism-specific databases

TAIRiAT5G44870.

Phylogenomic databases

eggNOGiCOG4886. LUCA.
HOGENOMiHOG000064702.
InParanoidiO48573.
OMAiYGCERLE.
PhylomeDBiO48573.

Miscellaneous databases

PROiO48573.

Gene expression databases

GenevisibleiO48573. AT.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF07725. LRR_3. 1 hit.
PF00931. NB-ARC. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor."
    Palma K., Thorgrimsen S., Malinovsky F.G., Fiil B.K., Nielsen H.B., Brodersen P., Hofius D., Petersen M., Mundy J.
    PLoS Pathog. 6:E1001137-E1001137(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, MUTAGENESIS OF ILE-287 AND GLY-811.
  5. "Arabidopsis TTR1 causes LRR-dependent lethal systemic necrosis, rather than systemic acquired resistance, to Tobacco ringspot virus."
    Nam M., Koh S., Kim S.U., Domier L.L., Jeon J.H., Kim H.G., Lee S.H., Bent A.F., Moon J.S.
    Mol. Cells 32:421-429(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: cv. Est.

Entry informationi

Entry nameiLAZ5_ARATH
AccessioniPrimary (citable) accession number: O48573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 1, 1998
Last modified: February 17, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants over-expressing LAZ5 exhibit hypersensitive cell death and do not survive (PubMed:20949080). In the ecotype Estland (Est), which shows a sensitive response upon tobacco ringspot virus (TRSV) inoculation, the TTR1 allele is involved in the development of lethal systemic necrosis in response to TRSV (PubMed:22057987).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.