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Protein

Outer envelope pore protein 16-3, chloroplastic/mitochondrial

Gene

OEP163

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-dependent high-conductance channel with a slightly cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars. Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer envelope pore protein 16-3, chloroplastic/mitochondrial
Alternative name(s):
Chloroplastic outer envelope pore protein of 16 kDa 3
Short name:
AtOEP16-3
Short name:
OEP16-3
Mitochondrial complex I subunit B14.7
Gene namesi
Name:OEP163
Synonyms:B14.7
Ordered Locus Names:At2g42210
ORF Names:T24P15.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G42210.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 40HelicalSequence analysisAdd BLAST17
Transmembranei62 – 79HelicalSequence analysisAdd BLAST18
Transmembranei92 – 109HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast outer membrane Source: UniProtKB-SubCell
  • membrane Source: TAIR
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrial respiratory chain complex I Source: TAIR
  • mitochondrion Source: TAIR
  • plastid outer membrane Source: TAIR
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Plastid, Plastid outer membrane

Pathology & Biotechi

Disruption phenotypei

Lethal when homozygous.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004156981 – 159Outer envelope pore protein 16-3, chloroplastic/mitochondrialAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO48528.
PRIDEiO48528.

Expressioni

Gene expression databases

GenevisibleiO48528. AT.

Interactioni

Subunit structurei

Homodimer and oligomers in membrane (By similarity). Part of both the NADH-ubiquinone oxidoreductase complex I and of the TIM17:23 complex. Interacts with TIM23-2.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4158. 1 interactor.
IntActiO48528. 1 interactor.
STRINGi3702.AT2G42210.2.

Structurei

3D structure databases

ProteinModelPortaliO48528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 65Contains beta strandsBy similarityAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3225. Eukaryota.
COG5596. LUCA.
HOGENOMiHOG000239422.
InParanoidiO48528.
OMAiQTTRIDN.
OrthoDBiEOG09360OS2.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O48528-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAEMRYLE EEDGPLMKTI KGSITGFGAG TIYGTILATW KDVPRVERNV
60 70 80 90 100
ALPGLIRTLK MMGTHGLTFA AIGGVYIGVE QLVQNFRSKR DFYNGAIGGF
110 120 130 140 150
VAGASVLGYR ARSIPTAIAA GATLAVTSAL IDSGGQTTRV DNGREYYPYT

VEKRAEADS
Length:159
Mass (Da):16,999
Last modified:June 1, 1998 - v1
Checksum:i3102BC2ACFA389E7
GO
Isoform 2 (identifier: O48528-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFNLCALGRTVEEIM

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:173
Mass (Da):18,577
Checksum:iA500096BBDC6C4D2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0423211M → MFNLCALGRTVEEIM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ386643 mRNA. Translation: ABD48955.1.
AC002561 Genomic DNA. Translation: AAB88646.1.
CP002685 Genomic DNA. Translation: AEC10086.1.
CP002685 Genomic DNA. Translation: AEC10087.1.
CP002685 Genomic DNA. Translation: AEC10088.1.
CP002685 Genomic DNA. Translation: AEC10089.1.
AY086879 mRNA. Translation: AAM63925.1.
BT025617 mRNA. Translation: ABF59035.1.
PIRiT00930.
RefSeqiNP_001031527.1. NM_001036450.2. [O48528-2]
NP_001031528.1. NM_001036451.2. [O48528-1]
NP_001031529.1. NM_001036452.1. [O48528-1]
NP_565968.1. NM_129783.4. [O48528-1]
UniGeneiAt.12442.
At.67859.

Genome annotation databases

EnsemblPlantsiAT2G42210.1; AT2G42210.1; AT2G42210. [O48528-1]
AT2G42210.2; AT2G42210.2; AT2G42210. [O48528-2]
AT2G42210.3; AT2G42210.3; AT2G42210. [O48528-1]
AT2G42210.4; AT2G42210.4; AT2G42210. [O48528-1]
GeneIDi818821.
GrameneiAT2G42210.1; AT2G42210.1; AT2G42210.
AT2G42210.2; AT2G42210.2; AT2G42210.
AT2G42210.3; AT2G42210.3; AT2G42210.
AT2G42210.4; AT2G42210.4; AT2G42210.
KEGGiath:AT2G42210.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ386643 mRNA. Translation: ABD48955.1.
AC002561 Genomic DNA. Translation: AAB88646.1.
CP002685 Genomic DNA. Translation: AEC10086.1.
CP002685 Genomic DNA. Translation: AEC10087.1.
CP002685 Genomic DNA. Translation: AEC10088.1.
CP002685 Genomic DNA. Translation: AEC10089.1.
AY086879 mRNA. Translation: AAM63925.1.
BT025617 mRNA. Translation: ABF59035.1.
PIRiT00930.
RefSeqiNP_001031527.1. NM_001036450.2. [O48528-2]
NP_001031528.1. NM_001036451.2. [O48528-1]
NP_001031529.1. NM_001036452.1. [O48528-1]
NP_565968.1. NM_129783.4. [O48528-1]
UniGeneiAt.12442.
At.67859.

3D structure databases

ProteinModelPortaliO48528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4158. 1 interactor.
IntActiO48528. 1 interactor.
STRINGi3702.AT2G42210.2.

Proteomic databases

PaxDbiO48528.
PRIDEiO48528.

Protocols and materials databases

DNASUi818821.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G42210.1; AT2G42210.1; AT2G42210. [O48528-1]
AT2G42210.2; AT2G42210.2; AT2G42210. [O48528-2]
AT2G42210.3; AT2G42210.3; AT2G42210. [O48528-1]
AT2G42210.4; AT2G42210.4; AT2G42210. [O48528-1]
GeneIDi818821.
GrameneiAT2G42210.1; AT2G42210.1; AT2G42210.
AT2G42210.2; AT2G42210.2; AT2G42210.
AT2G42210.3; AT2G42210.3; AT2G42210.
AT2G42210.4; AT2G42210.4; AT2G42210.
KEGGiath:AT2G42210.

Organism-specific databases

TAIRiAT2G42210.

Phylogenomic databases

eggNOGiKOG3225. Eukaryota.
COG5596. LUCA.
HOGENOMiHOG000239422.
InParanoidiO48528.
OMAiQTTRIDN.
OrthoDBiEOG09360OS2.

Miscellaneous databases

PROiO48528.

Gene expression databases

GenevisibleiO48528. AT.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOP163_ARATH
AccessioniPrimary (citable) accession number: O48528
Secondary accession number(s): F4IMZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.