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O48500

- DUT_BPT5

UniProt

O48500 - DUT_BPT5

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
DUT
Organism
Enterobacteria phage T5 (Bacteriophage T5)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
OrganismiEnterobacteria phage T5 (Bacteriophage T5)
Taxonomic identifieri10726 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeT5likevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000002107: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182970Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO48500.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

O48500-1 [UniParc]FASTAAdd to Basket

« Hide

MIKIKLTHPD CMPKIGSEDA AGMDLRAFFG TNPAADLRAI APGKSLMIDT    50
GVAVEIPRGW FGLVVPRSSL GKRHLMIANT AGVIDSDYRG TIKMNLYNYG 100
SEMQTLENFE RLCQLVVLPH YSTHNFKIVD ELEETIRGEG GFGSSGSK 148
Length:148
Mass (Da):16,204
Last modified:June 1, 1998 - v1
Checksum:i4BD56DB1456EF430
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY543070 Genomic DNA. Translation: AAS77177.1.
RefSeqiYP_006959.1. NC_005859.1.

Genome annotation databases

GeneIDi2777637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY543070 Genomic DNA. Translation: AAS77177.1 .
RefSeqi YP_006959.1. NC_005859.1.

3D structure databases

ProteinModelPortali O48500.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2777637.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of the bacteriophage T5 dUTPase by protein sequence comparisons."
    Kaliman A.V.
    DNA Seq. 6:347-350(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDUT_BPT5
AccessioniPrimary (citable) accession number: O48500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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