Reviewed,
UniProtKB/Swiss-Prot O47950 (NDUS7_NEUCR)
Last modified
November 25, 2008.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADH-ubiquinone oxidoreductase 19.3 kDa subunit, mitochondrial EC=1.6.5.3 EC=1.6.99.3 Alternative name(s): Complex I-19.3kD Short name=CI-19.3kD | ||
| Gene names |
| ||
| Organism | Neurospora crassa [Complete proteome] | ||
| Taxonomic identifier | 5141 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora |
Protein attributes
| Sequence length | 226 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. |
| Catalytic activity | NADH + ubiquinone = NAD(+) + ubiquinol. NADH + acceptor = NAD(+) + reduced acceptor. |
| Cofactor | Binds 1 4Fe-4S cluster Potential. |
| Subunit structure | Complex I is composed of about 40 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. |
| Subcellular location | |
| Sequence similarities | Belongs to the complex I 20 kDa subunit family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Electron transport Respiratory chain Transport |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding NAD Ubiquinone |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activityInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | |||||||
| Chain | ? – 226 | NADH-ubiquinone oxidoreductase 19.3 kDa subunit, mitochondrial | PRO_0000020032 | ||||||
Sites | |||||||||
| Metal binding | 101 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 102 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 166 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 196 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AJ001520 mRNA. Translation: CAA04802.1. BX908812 Genomic DNA. Translation: CAF06152.1. AABX02000012 Genomic DNA. Translation: EAA28356.1. | |
| RefSeq | XP_957592.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3873682. |
| KEGG | ncr:NCU03953. |
| NMPDR | fig|5141.1.peg.1205. |
Enzyme and pathway databases | |
| BioCyc | NCRA-XX3-01:NCRA-XX3-01-007701-MON. |
Family and domain databases | |
| InterPro | IPR006138. NADH_DHase_20kDa_su. IPR014406. NiFe_hyd_3_ssu/Q_oxred_NuoB. IPR006137. OxRdtase_q6. [Graphical view] |
| PANTHER | PTHR11995:SF2. NADH_DH_20kDa. 1 hit. PTHR11995. NiFe_hyd_3_ssu/Q_oxred_NuoB. 1 hit. |
| Pfam | PF01058. Oxidored_q6. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01957. nuoB_fam. 1 hit. |
| PROSITE | PS01150. COMPLEX1_20K. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NDUS7_NEUCR | ||||||||
| Accession | Primary (citable) accession number: O47950 Secondary accession number(s): Q7RZB4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

Clusters with


