Reviewed, UniProtKB/Swiss-Prot O47892 (CYB_HYLLE)

Names and origin

Protein names

Recommended name:
    Cytochrome b
Alternative name(s):
    Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
    Cytochrome b-c1 complex subunit 3
    Complex III subunit 3
    Complex III subunit III

Gene names

Name:	MT-CYB
Synonyms:	COB, CYTB, MTCYB

Encoded on

Mitochondrion

Organism

Hylobates leucogenys (White-cheeked gibbon)

Taxonomic identifier

61853 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hylobatidae › Nomascus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.
Sequence similarities	Belongs to the cytochrome b family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Ligand	Heme Iron Metal-binding
Gene Ontology (GO)
Biological process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Cytochrome b		PRO_0000061053
Regions
	Transmembrane	33 – 53	21	Potential
	Transmembrane	76 – 98	23	Potential
	Transmembrane	115 – 135	21	Potential
	Transmembrane	138 – 158	21	Potential
	Transmembrane	178 – 198	21	Potential
	Transmembrane	229 – 249	21	Potential
	Transmembrane	288 – 308	21	Potential
	Transmembrane	323 – 343	21	Potential
	Transmembrane	346 – 366	21	Potential
Sites
	Metal binding	83	1	Iron 1 (heme b562 axial ligand)
	Metal binding	97	1	Iron 2 (heme b566 axial ligand)
	Metal binding	182	1	Iron 1 (heme b562 axial ligand)
	Metal binding	196	1	Iron 2 (heme b566 axial ligand)

Sequences

	Sequence		Length	Mass (Da)
	O47892-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: BE078D2C4BB1E9A9	FASTA	380	42,826
	10 20 30 40 50 60 MTPLRKTNPL VKLINHSLVD LPAPSNISMW WNLGSLLGTC LILQIVTGLF LAMHYTPDAS 70 80 90 100 110 120 MAFSSVAHIT RDVNYGWVIR YLHANGASMF FICLFLHIGR GMYYGSFLYL ETWNIGIILL 130 140 150 160 170 180 LATMATAFMG YVLPWGQMSF WGATVITNLL SAVPYIGTDL VQWVWGGYSV DNATLTRFFT 190 200 210 220 230 240 FHFILPFIIT ALVTLHLLFL HETGSNNPLG ISSQPDKITF HPYYTTKDIL GLFLLLLTLM 250 260 270 280 290 300 SLVLFSPDLL GDPDNYIQAN PLSTPPHIKP EWYFLFAYAI LRSVPNKLGG VLALLLSILI 310 320 330 340 350 360 LMTIPMLHTA KQQSMMFRPL SQLTYWLWAA NLLTLTWIGG QPVSYPFITI GQVTSVLYFI 370 380 TILILMPTAS LIENKMLKWT

References

[1]	"Evolution of the gibbon subgenera inferred from cytochrome b DNA sequence data." Hall L.M., Jones D.S., Wood B.A. Mol. Phylogenet. Evol. 10:281-286(1998) [PubMed: 10051381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y13306 Genomic DNA. Translation: CAA73742.1.
3D structure databases
SMR	O47892. Positions 2-379.
ModBase	Search...
Phylogenomic databases
HOVERGEN	O47892.
Family and domain databases
InterPro	IPR016175. Cyt_b/b6. IPR005798. Cyt_b/b6_C. IPR005797. Cyt_b/b6_N. IPR016174. Di-haem_cyt_TM. [Graphical view]
Gene3D	G3DSA:1.20.810.10. Cytochrome_b/b6. 1 hit.
PANTHER	PTHR19271. Cytochrome_b/b6. 1 hit.
Pfam	PF00032. Cytochrom_B_C. 1 hit. PF00033. Cytochrom_B_N. 1 hit. [Graphical view]
PROSITE	PS51003. CYTB_CTER. 1 hit. PS51002. CYTB_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYB_HYLLE

Accession

Primary (citable) accession number: O47892

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	June 1, 1998
Last modified:	November 24, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)