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Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Alligator mississippiensis (American alligator)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiAlligator mississippiensis (American alligator)
Taxonomic identifieri8496 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 62Mitochondrial matrixSequence analysisAdd BLAST15
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Topological domaini83 – 229Mitochondrial intermembraneSequence analysisAdd BLAST147

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834891 – 229Cytochrome c oxidase subunit 2Add BLAST229

Structurei

3D structure databases

ProteinModelPortaliO47870
SMRiO47870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727
KOiK02261
OrthoDBiEOG091G0IO9

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

O47870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPTHLGFQ DAMSPLMEEL LYFHDHTLMI LFLISSLVFY MIFALLFPKL
60 70 80 90 100
YYPNTSDVQE VEVIWTVLPA IVLISIALPS LRTLYLMDET NNPCLTIKVT
110 120 130 140 150
GHQWYWSYEY TDFSTLEFDS YMIPTQDLPQ GHFRLLEVDH RMITPTNSTI
160 170 180 190 200
RVLITAEDVL HSWAIPSIGT KMDAVPGRLN QVMITLANPG VFYGQCSEIC
210 220
GANHSFMPIT METIPLNHFQ LWLEDSILS
Length:229
Mass (Da):26,269
Last modified:June 1, 1998 - v1
Checksum:iA6F79DBC3C3F2B8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13113 Genomic DNA Translation: CAA73564.1
AF069428 Genomic DNA Translation: AAD09983.1
PIRiT11277
RefSeqiNP_007565.1, NC_001922.1

Genome annotation databases

GeneIDi808245
KEGGiamj:808245

Similar proteinsi

Entry informationi

Entry nameiCOX2_ALLMI
AccessioniPrimary (citable) accession number: O47870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health