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O47870

- COX2_ALLMI

UniProt

O47870 - COX2_ALLMI

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Protein

Cytochrome c oxidase subunit 2

Gene
MT-CO2, COII, COXII, MTCO2
Organism
Alligator mississippiensis (American alligator)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper A Inferred
Metal bindingi196 – 1961Copper A Inferred
Metal bindingi200 – 2001Copper A Inferred
Metal bindingi204 – 2041Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiAlligator mississippiensis (American alligator)
Taxonomic identifieri8496 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Reviewed predictionAdd
BLAST
Topological domaini48 – 6215Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei63 – 8220Helical; Reviewed predictionAdd
BLAST
Topological domaini83 – 229147Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Cytochrome c oxidase subunit 2PRO_0000183489Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO47870.
SMRiO47870. Positions 1-222.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O47870-1 [UniParc]FASTAAdd to Basket

« Hide

MANPTHLGFQ DAMSPLMEEL LYFHDHTLMI LFLISSLVFY MIFALLFPKL    50
YYPNTSDVQE VEVIWTVLPA IVLISIALPS LRTLYLMDET NNPCLTIKVT 100
GHQWYWSYEY TDFSTLEFDS YMIPTQDLPQ GHFRLLEVDH RMITPTNSTI 150
RVLITAEDVL HSWAIPSIGT KMDAVPGRLN QVMITLANPG VFYGQCSEIC 200
GANHSFMPIT METIPLNHFQ LWLEDSILS 229
Length:229
Mass (Da):26,269
Last modified:June 1, 1998 - v1
Checksum:iA6F79DBC3C3F2B8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13113 Genomic DNA. Translation: CAA73564.1.
AF069428 Genomic DNA. Translation: AAD09983.1.
PIRiT11277.
RefSeqiNP_007565.1. NC_001922.1.

Genome annotation databases

GeneIDi808245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13113 Genomic DNA. Translation: CAA73564.1 .
AF069428 Genomic DNA. Translation: AAD09983.1 .
PIRi T11277.
RefSeqi NP_007565.1. NC_001922.1.

3D structure databases

ProteinModelPortali O47870.
SMRi O47870. Positions 1-222.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808245.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

HOVERGENi HBG012727.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete mitochondrial genome of Alligator mississippiensis and the separation between recent archosauria (birds and crocodiles)."
    Janke A., Arnason U.
    Mol. Biol. Evol. 14:1266-1272(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Primers for a PCR-based approach to complete mitochondrial genome sequencing."
    Sorenson M.D., Dimcheff D.E., Ast J.C., Yuri T., Mindell D.P.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_ALLMI
AccessioniPrimary (citable) accession number: O47870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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