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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Geomys personatus (Texas pocket gopher)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:ND5
Synonyms:NAD5, NADH5
Encoded oniMitochondrion
OrganismiGeomys personatus (Texas pocket gopher)
Taxonomic identifieri35659 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiGeomyidaeGeomys

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence analysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence analysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence analysisAdd
BLAST
Transmembranei453 – 47321HelicalSequence analysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence analysisAdd
BLAST
Transmembranei509 – 52921HelicalSequence analysisAdd
BLAST
Transmembranei578 – 59821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599NADH-ubiquinone oxidoreductase chain 5PRO_0000254950Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

O47815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMIFSMVF MFILLFKPLV FSMMNKKCLN STYTSTVKWA FITSMIPLMM
60 70 80 90 100
YMNSSKEIII LNWHWLTVHT IELKMSFKLD LYSITFMPVA LYVTWSIMEY
110 120 130 140 150
STWYMKHDPH LKRFLNYLSL FLITMLILVT ANNMFQLFIG WEGVGIMSFL
160 170 180 190 200
LIGWWYGRTD ANTAALQAII YNRVGDIGLV IAMAWFYKNS NSWELQQIFS
210 220 230 240 250
LGTTSNLPLI GLILAAMGKS AQFGLHPWLP SAMEGPTPVS ALLHSSTMVV
260 270 280 290 300
AGVFLLIRFH PLMSNNSMIM TTILCIGAMT TLFTAICALT QNDIKKIIAF
310 320 330 340 350
STSSQLGLMM VTLGINQPYL SFLHICTHAF FKAMLFMCAG SIIHNLNDEQ
360 370 380 390 400
DIRKMGGISK TMPLTASAMT IGNLALMGTP FMSGFYSKDL IIESMNTSNI
410 420 430 440 450
NSWALITTLI ATSLTAAYST RLIYFVLSNS PRCNSVINMN ESDNKLTSPI
460 470 480 490 500
KRLMLGSIFA GFLLSNFIQP VNMQNMTMPF TIKITAMLVT IMGVIVAMEL
510 520 530 540 550
NLMTQYMKMY PNNYNFNFSI MLGFFPTIIH RSVSKSFLNF NQKIATSLMD
560 570 580 590
YMWLEKIVPN AVVMMNNAAS ATTSTHKGML KIYFMSFILS MVMLMLIMS
Length:599
Mass (Da):67,687
Last modified:June 1, 1998 - v1
Checksum:iB52B6E2DF115547A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041078 Genomic DNA. Translation: AAB96777.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041078 Genomic DNA. Translation: AAB96777.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular evidence for centrifugal speciation in pocket gophers of the Geomys personatus complex."
    Wickliffe J.K., Dahl C.R., Horner P., Smolen M.J., Bickham J.W.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU5M_GEOPE
AccessioniPrimary (citable) accession number: O47815
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 1998
Last modified: September 16, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.