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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene
N/A
Organism
Onchocerca volvulus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Encoded oniMitochondrionImported
OrganismiOnchocerca volvulusImported
Taxonomic identifieri6282 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeOnchocerca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence analysisAdd
BLAST
Transmembranei35 – 6430HelicalSequence analysisAdd
BLAST
Transmembranei71 – 8919HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11319HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14824HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18122HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21119HelicalSequence analysisAdd
BLAST
Transmembranei217 – 24024HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26923HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29824HelicalSequence analysisAdd
BLAST
Transmembranei310 – 33122HelicalSequence analysisAdd
BLAST
Transmembranei351 – 37929HelicalSequence analysisAdd
BLAST
Transmembranei391 – 40818HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 353266Proton_antipo_MInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.

Sequencei

Sequence statusi: Complete.

O47572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLFFFVVL LFFFSPFLFF VFFMFFVLYG FFDYSWFGCL FFFDSFNFVF
60 70 80 90 100
LSFMSVFVMG FICVSELLSG LVFYSCLVVF FSVCFFYSGS FLMLYVFYEL
110 120 130 140 150
TMVPILFCLL GYGRQVEKIS ACYYLIFYTL FFGMPYLFLY SHVFFFLNFV
160 170 180 190 200
YYDFFVSYEF IFLLSLCFLV KFPVYFFHVW LPKVHVEAPT SASMILAGVM
210 220 230 240 250
LKLGGAGVYR ISKSLNFFGF EMLIFFSLIS MVFCSFICVV QSDCKSLAAY
260 270 280 290 300
SSVCHMGFVL LSEISMVYYG KSMALVMMLA HGYTSVLMFY FIGEFYHIAN
310 320 330 340 350
SRLIYYLRGY FNVSMLFCLM FCLTMVSNFS FPVSVSFFSE YLMLNFFSSV
360 370 380 390 400
FYVGFLFLFF YYLVSFYYSV YILVCFLVGG KVSYVCDGRS VVCLPLVFMM
410
YNFFWFIFVI
Length:410
Mass (Da):48,460
Last modified:June 1, 1998 - v1
Checksum:iF05EEB8B8BB13B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015193 Genomic DNA. Translation: AAC61611.1.
PIRiT11064.
RefSeqiNP_008369.1. NC_001861.1.

Genome annotation databases

GeneIDi808148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015193 Genomic DNA. Translation: AAC61611.1.
PIRiT11064.
RefSeqiNP_008369.1. NC_001861.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808148.

Organism-specific databases

CTDi4538.

Family and domain databases

InterProiIPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
ProtoNetiSearch...

Entry informationi

Entry nameiO47572_ONCVO
AccessioniPrimary (citable) accession number: O47572
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 13, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.