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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Chlamydomonas moewusii (Chlamydomonas eugametos)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiChlamydomonas moewusii (Chlamydomonas eugametos)Imported
Taxonomic identifieri3054 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3823HelicalSequence analysisAdd
BLAST
Transmembranei58 – 8326HelicalSequence analysisAdd
BLAST
Transmembranei103 – 12422HelicalSequence analysisAdd
BLAST
Transmembranei144 – 17027HelicalSequence analysisAdd
BLAST
Transmembranei182 – 21029HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25122HelicalSequence analysisAdd
BLAST
Transmembranei263 – 28624HelicalSequence analysisAdd
BLAST
Transmembranei298 – 32225HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35522HelicalSequence analysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST
Transmembranei407 – 42822HelicalSequence analysisAdd
BLAST
Transmembranei448 – 46922HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO47547.
SMRiO47547. Positions 2-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 507507COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O47547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIRWLYSTN HKDIGILYLV LALFAGIIGT TLSMFIRLEL GLPGSGLLNG
60 70 80 90 100
NGQLYNVIIT GHGIIMLLFM VMPALFGGFG NWLVPILIGA PDMAFPRLNN
110 120 130 140 150
ISFWLNPSAL GLLLLSTMVE QGAGTGWTAY PPLSIQSTGA AVDLAILSLH
160 170 180 190 200
LNGLSSILGS INILVTIAGM RAIGMKLSQM PLFVWSIAFT AILVILAVPV
210 220 230 240 250
LAAALVMLLT DRNLNTAYFC ESGDLILYQH LFWFFGHPEV YILILPAFGI
260 270 280 290 300
VSHVISFFSQ KPIFGNMGMI CAMGAISILG FIVWAHHMFT VGLDLDTIAY
310 320 330 340 350
FTSATMIIAV PTGMKIFSWL ATIYGGSLWL TTPMWFAVGF ICLFTLGGVT
360 370 380 390 400
GVVLANAGVD MLVHDTYYVV GHFHYVLSMG ASFGIFAGIY FCQFKTGLTY
410 420 430 440 450
IESRGQVQFW TLFIGVNLTF FPMHMMGLGG MPRRMFDYAD CFYGWNSIAS
460 470 480 490 500
FVALISFLSI LMLAGPINFM PEINTKSNTY PRSATTLEWM DHSTPASHVF

MQLPVIRSY
Length:509
Mass (Da):55,847
Last modified:June 1, 1998 - v1
Checksum:i8EAA06905EA00E12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008237 Genomic DNA. Translation: AAC39342.1.
PIRiT11043.
RefSeqiNP_046144.1. NC_001872.1.

Genome annotation databases

GeneIDi800385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008237 Genomic DNA. Translation: AAC39342.1.
PIRiT11043.
RefSeqiNP_046144.1. NC_001872.1.

3D structure databases

ProteinModelPortaliO47547.
SMRiO47547. Positions 2-508.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi800385.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO47547_CHLMO
AccessioniPrimary (citable) accession number: O47547
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.