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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

nad4

Organism
Chlamydomonas moewusii (Chlamydomonas eugametos)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad4Imported
Encoded oniMitochondrionImported
OrganismiChlamydomonas moewusii (Chlamydomonas eugametos)Imported
Taxonomic identifieri3054 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 60HelicalSequence analysisAdd BLAST20
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei107 – 124HelicalSequence analysisAdd BLAST18
Transmembranei130 – 149HelicalSequence analysisAdd BLAST20
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei216 – 238HelicalSequence analysisAdd BLAST23
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei308 – 327HelicalSequence analysisAdd BLAST20
Transmembranei333 – 357HelicalSequence analysisAdd BLAST25
Transmembranei364 – 394HelicalSequence analysisAdd BLAST31
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei477 – 494HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 424Proton_antipo_MInterPro annotationAdd BLAST297

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O47543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLTSFAFF IPNGVDNKYT HKEKTINGLI GEGYYSITKT YCLFVTMVVL
60 70 80 90 100
LWTLYLWSIY DAIGHSLQMV VIIERLHISF GVDSMSLSLT LLTSALFPIC
110 120 130 140 150
IMVMRTFKGY ITFLLLEIVI YGALNVLDLL GFYILFEASL ILLFLLIGRS
160 170 180 190 200
VYGNIEAAYK IVLYTMGGSL ILLPIIFVLY AQGGSTSLIY LLCNFGSQHA
210 220 230 240 250
DAYQSAYYLL SERQMILGWG LFIVFAVKIP LMPVHLWLPE AHVAAPTAGS
260 270 280 290 300
VLLAGVLLKL GGLGFIRFMI PILPSFTASI FPLVCCMCLA SFLYSTLSTI
310 320 330 340 350
RQIDLKKIVA YSSIGHMAMI TLTIFTMSEY SAYNATFMMI AHGLVSPCLF
360 370 380 390 400
LLVGLLYDRF HTKLIFYFTG LAAHLPIFSI MFLLCTLANL SFPLFPNFLA
410 420 430 440 450
EFLCLTSLFS VHSLYAYVFC ICQVLGTVAS FWAFNRIIHG VAFGLTSNYK
460 470 480 490
INQNASACDA TRRVIVNNQY TTPLNRLEFA MVLTLMIGII WLGVKPMA
Length:498
Mass (Da):55,620
Last modified:June 1, 1998 - v1
Checksum:i5989B83D2BB3FEC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008237 Genomic DNA. Translation: AAC39340.1.
PIRiT11039.
RefSeqiNP_046140.1. NC_001872.1.

Genome annotation databases

GeneIDi800378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008237 Genomic DNA. Translation: AAC39340.1.
PIRiT11039.
RefSeqiNP_046140.1. NC_001872.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi800378.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO47543_CHLMO
AccessioniPrimary (citable) accession number: O47543
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 13, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.