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O47496 (COX2_METSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismMetridium senile (Brown sea anemone) (Frilled sea anemone)
Taxonomic identifier6116 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Cytochrome c oxidase subunit 2
PRO_0000183633

Regions

Topological domain1 – 4343Mitochondrial intermembrane Potential
Transmembrane44 – 6522Helical; Potential
Topological domain66 – 7914Mitochondrial matrix Potential
Transmembrane80 – 9920Helical; Potential
Topological domain100 – 248149Mitochondrial intermembrane Potential

Sites

Metal binding1801Copper A Probable
Metal binding2151Copper A Probable
Metal binding2191Copper A Probable
Metal binding2231Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
O47496 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: A14199E19D383D96

FASTA24828,294
        10         20         30         40         50         60 
MTNLLNNWLI INQFGYDLPE PWQLGLQDAA HPVMEEIIFF HDQVMFILII IITTVLWLIV 

        70         80         90        100        110        120 
KALSGKAYHR YLVDGTLLEI IWTIVPAIIL ILIAFPSLKL LYLMDEVMDP ALTIKAIGHQ 

       130        140        150        160        170        180 
WYWSYEYSDY QTETLEFDSY MVPTSELNKG DFRLLEVDNR LVVPINTHVR VLVTGADVLH 

       190        200        210        220        230        240 
SFAVPALAVK MDAIPGRLNQ TGFFIKRPGI FYGQCSEICG ANHSFMPIVI EAVSLDKYIN 


WVLSGSDE 

« Hide

References

[1]"Mitochondrial DNA of the sea anemone, Metridium senile (Cnidaria): prokaryote-like genes for tRNA(f-Met) and small-subunit ribosomal RNA, and standard genetic code specificities for AGR and ATA codons."
Pont-Kingdon G.A., Beagley C.T., Okimoto R., Wolstenholme D.R.
J. Mol. Evol. 39:387-399(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Beagley C.T., Okimoto R., Wolstenholme D.R.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: White morph.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75445 Genomic DNA. Translation: AAB32498.1.
AF000023 Genomic DNA. Translation: AAC04639.1.
PIRT11893.
RefSeqNP_009262.1. NC_000933.1.

3D structure databases

ProteinModelPortalO47496.
SMRO47496. Positions 18-244.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808777.

Organism-specific databases

CTD4513.

Phylogenomic databases

ProtClustDBMTH00023.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_METSE
AccessionPrimary (citable) accession number: O47496
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families