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O47496

- COX2_METSE

UniProt

O47496 - COX2_METSE

Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Metridium senile (Brown sea anemone) (Frilled sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi180 – 1801Copper ACurated
    Metal bindingi215 – 2151Copper ACurated
    Metal bindingi219 – 2191Copper ACurated
    Metal bindingi223 – 2231Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COII
    Encoded oniMitochondrion
    OrganismiMetridium senile (Brown sea anemone) (Frilled sea anemone)
    Taxonomic identifieri6116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Cytochrome c oxidase subunit 2PRO_0000183633Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO47496.
    SMRiO47496. Positions 18-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini66 – 7914Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini100 – 248149Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6522HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 9920HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O47496-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNLLNNWLI INQFGYDLPE PWQLGLQDAA HPVMEEIIFF HDQVMFILII    50
    IITTVLWLIV KALSGKAYHR YLVDGTLLEI IWTIVPAIIL ILIAFPSLKL 100
    LYLMDEVMDP ALTIKAIGHQ WYWSYEYSDY QTETLEFDSY MVPTSELNKG 150
    DFRLLEVDNR LVVPINTHVR VLVTGADVLH SFAVPALAVK MDAIPGRLNQ 200
    TGFFIKRPGI FYGQCSEICG ANHSFMPIVI EAVSLDKYIN WVLSGSDE 248
    Length:248
    Mass (Da):28,294
    Last modified:June 1, 1998 - v1
    Checksum:iA14199E19D383D96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75445 Genomic DNA. Translation: AAB32498.1.
    AF000023 Genomic DNA. Translation: AAC04639.1.
    PIRiT11893.
    RefSeqiNP_009262.1. NC_000933.1.

    Genome annotation databases

    GeneIDi808777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75445 Genomic DNA. Translation: AAB32498.1 .
    AF000023 Genomic DNA. Translation: AAC04639.1 .
    PIRi T11893.
    RefSeqi NP_009262.1. NC_000933.1.

    3D structure databases

    ProteinModelPortali O47496.
    SMRi O47496. Positions 18-244.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 808777.

    Organism-specific databases

    CTDi 4513.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mitochondrial DNA of the sea anemone, Metridium senile (Cnidaria): prokaryote-like genes for tRNA(f-Met) and small-subunit ribosomal RNA, and standard genetic code specificities for AGR and ATA codons."
      Pont-Kingdon G.A., Beagley C.T., Okimoto R., Wolstenholme D.R.
      J. Mol. Evol. 39:387-399(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Beagley C.T., Okimoto R., Wolstenholme D.R.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: White morph.

    Entry informationi

    Entry nameiCOX2_METSE
    AccessioniPrimary (citable) accession number: O47496
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3