Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Metridium senile (Brown sea anemone) (Frilled sea anemone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Copper ACurated1
Metal bindingi215Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiMetridium senile (Brown sea anemone) (Frilled sea anemone)
Taxonomic identifieri6116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43Mitochondrial intermembraneSequence analysisAdd BLAST43
Transmembranei44 – 65HelicalSequence analysisAdd BLAST22
Topological domaini66 – 79Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei80 – 99HelicalSequence analysisAdd BLAST20
Topological domaini100 – 248Mitochondrial intermembraneSequence analysisAdd BLAST149

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836331 – 248Cytochrome c oxidase subunit 2Add BLAST248

Structurei

3D structure databases

ProteinModelPortaliO47496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O47496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLLNNWLI INQFGYDLPE PWQLGLQDAA HPVMEEIIFF HDQVMFILII
60 70 80 90 100
IITTVLWLIV KALSGKAYHR YLVDGTLLEI IWTIVPAIIL ILIAFPSLKL
110 120 130 140 150
LYLMDEVMDP ALTIKAIGHQ WYWSYEYSDY QTETLEFDSY MVPTSELNKG
160 170 180 190 200
DFRLLEVDNR LVVPINTHVR VLVTGADVLH SFAVPALAVK MDAIPGRLNQ
210 220 230 240
TGFFIKRPGI FYGQCSEICG ANHSFMPIVI EAVSLDKYIN WVLSGSDE
Length:248
Mass (Da):28,294
Last modified:June 1, 1998 - v1
Checksum:iA14199E19D383D96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75445 Genomic DNA. Translation: AAB32498.1.
AF000023 Genomic DNA. Translation: AAC04639.1.
PIRiT11893.
RefSeqiNP_009262.1. NC_000933.1.

Genome annotation databases

GeneIDi808777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75445 Genomic DNA. Translation: AAB32498.1.
AF000023 Genomic DNA. Translation: AAC04639.1.
PIRiT11893.
RefSeqiNP_009262.1. NC_000933.1.

3D structure databases

ProteinModelPortaliO47496.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808777.

Organism-specific databases

CTDi4513.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_METSE
AccessioniPrimary (citable) accession number: O47496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 5, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.