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O47496

- COX2_METSE

UniProt

O47496 - COX2_METSE

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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Metridium senile (Brown sea anemone) (Frilled sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi180 – 1801Copper ACurated
Metal bindingi215 – 2151Copper ACurated
Metal bindingi219 – 2191Copper ACurated
Metal bindingi223 – 2231Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiMetridium senile (Brown sea anemone) (Frilled sea anemone)
Taxonomic identifieri6116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei44 – 6522HelicalSequence AnalysisAdd
BLAST
Topological domaini66 – 7914Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei80 – 9920HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 248149Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Cytochrome c oxidase subunit 2PRO_0000183633Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO47496.
SMRiO47496. Positions 18-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O47496-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNLLNNWLI INQFGYDLPE PWQLGLQDAA HPVMEEIIFF HDQVMFILII
60 70 80 90 100
IITTVLWLIV KALSGKAYHR YLVDGTLLEI IWTIVPAIIL ILIAFPSLKL
110 120 130 140 150
LYLMDEVMDP ALTIKAIGHQ WYWSYEYSDY QTETLEFDSY MVPTSELNKG
160 170 180 190 200
DFRLLEVDNR LVVPINTHVR VLVTGADVLH SFAVPALAVK MDAIPGRLNQ
210 220 230 240
TGFFIKRPGI FYGQCSEICG ANHSFMPIVI EAVSLDKYIN WVLSGSDE
Length:248
Mass (Da):28,294
Last modified:June 1, 1998 - v1
Checksum:iA14199E19D383D96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75445 Genomic DNA. Translation: AAB32498.1.
AF000023 Genomic DNA. Translation: AAC04639.1.
PIRiT11893.
RefSeqiNP_009262.1. NC_000933.1.

Genome annotation databases

GeneIDi808777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75445 Genomic DNA. Translation: AAB32498.1 .
AF000023 Genomic DNA. Translation: AAC04639.1 .
PIRi T11893.
RefSeqi NP_009262.1. NC_000933.1.

3D structure databases

ProteinModelPortali O47496.
SMRi O47496. Positions 18-244.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808777.

Organism-specific databases

CTDi 4513.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial DNA of the sea anemone, Metridium senile (Cnidaria): prokaryote-like genes for tRNA(f-Met) and small-subunit ribosomal RNA, and standard genetic code specificities for AGR and ATA codons."
    Pont-Kingdon G.A., Beagley C.T., Okimoto R., Wolstenholme D.R.
    J. Mol. Evol. 39:387-399(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Beagley C.T., Okimoto R., Wolstenholme D.R.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White morph.

Entry informationi

Entry nameiCOX2_METSE
AccessioniPrimary (citable) accession number: O47496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3