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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Metridium senile (Brown sea anemone) (Frilled sea anemone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Copper ACurated1
Metal bindingi215Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiMetridium senile (Brown sea anemone) (Frilled sea anemone)
Taxonomic identifieri6116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43Mitochondrial intermembraneSequence analysisAdd BLAST43
Transmembranei44 – 65HelicalSequence analysisAdd BLAST22
Topological domaini66 – 79Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei80 – 99HelicalSequence analysisAdd BLAST20
Topological domaini100 – 248Mitochondrial intermembraneSequence analysisAdd BLAST149

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836331 – 248Cytochrome c oxidase subunit 2Add BLAST248

Structurei

3D structure databases

ProteinModelPortaliO47496
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

O47496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLLNNWLI INQFGYDLPE PWQLGLQDAA HPVMEEIIFF HDQVMFILII
60 70 80 90 100
IITTVLWLIV KALSGKAYHR YLVDGTLLEI IWTIVPAIIL ILIAFPSLKL
110 120 130 140 150
LYLMDEVMDP ALTIKAIGHQ WYWSYEYSDY QTETLEFDSY MVPTSELNKG
160 170 180 190 200
DFRLLEVDNR LVVPINTHVR VLVTGADVLH SFAVPALAVK MDAIPGRLNQ
210 220 230 240
TGFFIKRPGI FYGQCSEICG ANHSFMPIVI EAVSLDKYIN WVLSGSDE
Length:248
Mass (Da):28,294
Last modified:June 1, 1998 - v1
Checksum:iA14199E19D383D96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75445 Genomic DNA Translation: AAB32498.1
AF000023 Genomic DNA Translation: AAC04639.1
PIRiT11893
RefSeqiNP_009262.1, NC_000933.1

Genome annotation databases

GeneIDi808777

Similar proteinsi

Entry informationi

Entry nameiCOX2_METSE
AccessioniPrimary (citable) accession number: O47496
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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