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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:ND5
Synonyms:NAD5, NADH5
Encoded oniMitochondrion
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
Proteomesi
  • UP000001554 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei28 – 4821HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence analysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Transmembranei398 – 42023HelicalSequence analysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence analysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence analysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence analysisAdd
BLAST
Transmembranei577 – 59721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599NADH-ubiquinone oxidoreductase chain 5PRO_0000118069Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.
InParanoidiO47430.
KOiK03883.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O47430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELWGVLSL TSLGVMVIFL FSKIKSSFAE SVKYAGYMNA VLLSILLMSD
60 70 80 90 100
ESEMLFLKWE WVKLGGYSLM ISFRFDLYTC CFFVVGLYVT WNILMFSFYY
110 120 130 140 150
MSTDPRIDLF CKYLGLFLIA MLLLVSAESL FQLLIGWEGV GIMSYLLISW
160 170 180 190 200
WYARSDANTA ALQAIFYNRV GDIGLLIMLM WSLVTLGDWS FTGLYALDFV
210 220 230 240 250
NTFFLLGVVL AAAGKSAQLG LHPWLPAAME GPTPVSSLLH SSTMVVAGVF
260 270 280 290 300
LLIRFSPIIL NHKEIQLMVF FLGTMTTLFS AICALAQNDM KKVVAFSTAS
310 320 330 340 350
QLGLMVTVVA GAGAPQLAFL HICMHAFFKA MLFMCSGGFI HGLQNEQDVR
360 370 380 390 400
KMGGLHSAAP ITSVCFFIGS AALMGVPFLA GFFSKDPIIE IININNLNSW
410 420 430 440 450
AVGLVLIATS FTAAYSVRLL YFSVGGVSRM LVLQPMNEEY GNLIGPLQRL
460 470 480 490 500
AYSSVIAGVV FIYFLSPNQI SCLSLPLSLK LAAVFVTLVG GLIAWDVVNL
510 520 530 540 550
LHREESVTNI PELAFEAQVG FYPLIMHKLI PKVWLNMGEM YQMQVMDRGW
560 570 580 590
TELALPQGLG GNYKIMADNV VNAQTSLIKM YIAVMVMMGG LILGIMICL
Length:599
Mass (Da):66,141
Last modified:June 1, 1998 - v1
Checksum:i9E04167704FA2990
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098298 Genomic DNA. Translation: AAB87999.1.
RefSeqiNP_007765.1. NC_000834.1.

Genome annotation databases

GeneIDi808734.
KEGGibfo:ND5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098298 Genomic DNA. Translation: AAB87999.1.
RefSeqiNP_007765.1. NC_000834.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808734.
KEGGibfo:ND5.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.
InParanoidiO47430.
KOiK03883.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_BRAFL
AccessioniPrimary (citable) accession number: O47430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 16, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.