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O47423 (NU4M_BRAFL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:ND4
Synonyms:NAD4, NADH4
Encoded onMitochondrion
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) [Reference proteome]
Taxonomic identifier7739 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452NADH-ubiquinone oxidoreductase chain 4
PRO_0000117908

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane29 – 4921Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane88 – 11023Helical; Potential
Transmembrane114 – 13623Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane252 – 27221Helical; Potential
Transmembrane282 – 30423Helical; Potential
Transmembrane309 – 33123Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane390 – 41021Helical; Potential
Transmembrane432 – 45221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O47423 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: A1F4C8F26FA077F9

FASTA45249,914
        10         20         30         40         50         60 
MNHLVLGYVG LVIGVIVTKK SMVWRVGQVG SVLLMLPATV LVNMNMTISN VSYMMTSDFV 

        70         80         90        100        110        120 
SLGLTVLSIW LLPLMLLASQ QHMVSESLIY QRVFVGCQVF LTGALVLAFM ASDLLLFYIA 

       130        140        150        160        170        180 
FESTLLPTLM LITRWGAQKE RYQAGTYFMF FTLVGSLPLL ICLIGQYQMV GSLALDLSYE 

       190        200        210        220        230        240 
GVFQLSYLVN FWWVGCILAF LVKLPLYGVH LWLPKAHVEA PIAGSMVLAG VLLKLGGYGM 

       250        260        270        280        290        300 
MRVSLMWGAT AMLSSEVFLA LALWGIVVMG GICLRQTDLK SLIAYSSVGH MALVVGGVLT 

       310        320        330        340        350        360 
GVAWGYNGAM VLMIAHGLVS SCLFCLANLW YERSSTRNLS GSRGLIMIFP LISSGWFLMS 

       370        380        390        400        410        420 
LMNMALPPAI NLFGELVAMV ALYNWSPYSI VYMSLGAVLT AAYSLYLFGM SQWGNTMKNY 

       430        440        450 
KNLYTITSRE YLLTTLHLVP AIYLIFYLGL MF 

« Hide

References

[1]"Complete sequence, gene arrangement, and genetic code of mitochondrial DNA of the cephalochordate Branchiostoma floridae (Amphioxus)."
Boore J.L., Daehler L.L., Brown W.M.
Mol. Biol. Evol. 16:410-418(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF098298 Genomic DNA. Translation: AAB87992.1.
RefSeqNP_007764.1. NC_000834.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808733.
KEGGbfo:ND4.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.
KOK03881.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_BRAFL
AccessionPrimary (citable) accession number: O47423
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families