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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

ND4

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:ND4
Synonyms:NAD4, NADH4
Encoded oniMitochondrion
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
Proteomesi
  • UP000001554 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei88 – 110HelicalSequence analysisAdd BLAST23
Transmembranei114 – 136HelicalSequence analysisAdd BLAST23
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei282 – 304HelicalSequence analysisAdd BLAST23
Transmembranei309 – 331HelicalSequence analysisAdd BLAST23
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179081 – 452NADH-ubiquinone oxidoreductase chain 4Add BLAST452

Structurei

3D structure databases

ProteinModelPortaliO47423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.
InParanoidiO47423.
KOiK03881.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O47423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHLVLGYVG LVIGVIVTKK SMVWRVGQVG SVLLMLPATV LVNMNMTISN
60 70 80 90 100
VSYMMTSDFV SLGLTVLSIW LLPLMLLASQ QHMVSESLIY QRVFVGCQVF
110 120 130 140 150
LTGALVLAFM ASDLLLFYIA FESTLLPTLM LITRWGAQKE RYQAGTYFMF
160 170 180 190 200
FTLVGSLPLL ICLIGQYQMV GSLALDLSYE GVFQLSYLVN FWWVGCILAF
210 220 230 240 250
LVKLPLYGVH LWLPKAHVEA PIAGSMVLAG VLLKLGGYGM MRVSLMWGAT
260 270 280 290 300
AMLSSEVFLA LALWGIVVMG GICLRQTDLK SLIAYSSVGH MALVVGGVLT
310 320 330 340 350
GVAWGYNGAM VLMIAHGLVS SCLFCLANLW YERSSTRNLS GSRGLIMIFP
360 370 380 390 400
LISSGWFLMS LMNMALPPAI NLFGELVAMV ALYNWSPYSI VYMSLGAVLT
410 420 430 440 450
AAYSLYLFGM SQWGNTMKNY KNLYTITSRE YLLTTLHLVP AIYLIFYLGL

MF
Length:452
Mass (Da):49,914
Last modified:June 1, 1998 - v1
Checksum:iA1F4C8F26FA077F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098298 Genomic DNA. Translation: AAB87992.1.
RefSeqiNP_007764.1. NC_000834.1.

Genome annotation databases

GeneIDi808733.
KEGGibfo:ND4.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098298 Genomic DNA. Translation: AAB87992.1.
RefSeqiNP_007764.1. NC_000834.1.

3D structure databases

ProteinModelPortaliO47423.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808733.
KEGGibfo:ND4.

Organism-specific databases

CTDi4538.

Phylogenomic databases

HOVERGENiHBG093667.
InParanoidiO47423.
KOiK03881.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_BRAFL
AccessioniPrimary (citable) accession number: O47423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.