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Protein
Submitted name:

MHC class I alpha chain 2

Gene

B-FIV

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I alpha chain 2Imported
Submitted name:
MHC class I glycoproteinImported
Submitted name:
MHC class I moleculeImported
Gene namesi
Name:B-FIVImported
Synonyms:BF2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei298 – 32326HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: AgBase
  • integral component of membrane Source: UniProtKB-KW
  • MHC class I protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 355334Sequence analysisPRO_5007696868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 182Combined sources
Disulfide bondi220 ↔ 276Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000233.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E0RX-ray2.26A/D22-291[»]
4G42X-ray2.29A/D22-291[»]
4G43X-ray1.80A/D22-291[»]
SMRiO46790. Positions 22-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 28280Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPCGALGLG LLLAAVCGAA AELHTLRYIR TAMTDPGPGQ PWFVTVGYVD
60 70 80 90 100
GELFVHYNST ARRYVPRTEW IAANTDQQYW DGQTQIGQLN EQINRENLGI
110 120 130 140 150
RQRRYNQTGG SHTVQWMFGC DILEDGTIRG YRQSAYDGRD FIALDKDMKT
160 170 180 190 200
FTAAVPEAVP TKRKWEEESE PERWKNYLEE TCVEWLRRYV EYGKAELGRR
210 220 230 240 250
ERPEVRVWGK EADGILTLSC RAHGFYPRPI VVSWLKDGAV RGQDAHSGGI
260 270 280 290 300
VPNGDGTYHT WVTIDAQPGD GDKYQCRVEH ASLPQPGLYS WEPPQPNLVP
310 320 330 340 350
IVAGVAVAIV AIAIVVGVGF IIYRRHAGKK GKGYNIAPDR EGGSSSSSTG

SNPTI
Length:355
Mass (Da):39,398
Last modified:June 1, 1998 - v1
Checksum:i8B08E669AEF5AE37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013494 mRNA. Translation: AAC17591.1.
AB426148 Genomic DNA. Translation: BAG69400.1.
AM282693 Genomic DNA. Translation: CAK54654.1.
AM282699 Genomic DNA. Translation: CAK54660.1.
UniGeneiGga.33600.
Gga.4973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013494 mRNA. Translation: AAC17591.1.
AB426148 Genomic DNA. Translation: BAG69400.1.
AM282693 Genomic DNA. Translation: CAK54654.1.
AM282699 Genomic DNA. Translation: CAK54660.1.
UniGeneiGga.33600.
Gga.4973.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E0RX-ray2.26A/D22-291[»]
4G42X-ray2.29A/D22-291[»]
4G43X-ray1.80A/D22-291[»]
SMRiO46790. Positions 22-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO46790_CHICK
AccessioniPrimary (citable) accession number: O46790
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.