O46689 (STAR_HORSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Steroidogenic acute regulatory protein, mitochondrial
Short name=StAR

Alternative name(s):
START domain-containing protein 1
Short name=StARD1

Gene names

Name:

STAR

Organism

Equus caballus (Horse) [Reference proteome]

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone By similarity.
Pathway	Steroid metabolism; cholesterol metabolism.
Subunit structure	May interact with TSPO By similarity.
Subcellular location	Mitochondrion.
Sequence similarities	Contains 1 START domain.

Ontologies

Keywords
Biological process	Lipid transport Steroidogenesis Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cholesterol metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cholesterol transport Inferred from electronic annotation. Source: GOC steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cholesterol binding Inferred from electronic annotation. Source: InterPro cholesterol transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 63	63	Mitochondrion By similarity
	Chain	64 – 285	222	Steroidogenic acute regulatory protein, mitochondrial		PRO_0000033315
Regions
	Domain	67 – 280	214	START
Amino acid modifications
	Modified residue	57	1	Phosphoserine; by PKA By similarity
	Modified residue	195	1	Phosphoserine; by PKA By similarity

Sequences

	Sequence		Length	Mass (Da)
	O46689 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: B0360EF93299727D	FASTA	285	31,853
	10 20 30 40 50 60 MLLATFKLCA GSSYRHVRNM KGLRHQAALA IGQELNWRAP GGPTQSGWIN QVRRQSSLLG 70 80 90 100 110 120 SQLEDTLYSD QELAYIQQGE EAMQKALGIL RNQEGWKEEN QQANGDKVLS KVVPDVGKVF 130 140 150 160 170 180 RLEVEVDQPM ERLYEELVER MEAMGEWNPN VKEIKVLQKI GKDTVITHEL AAESAGNLVG 190 200 210 220 230 240 PRDFVSVRCA KRRGSTCVLA GMATQFEEMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT 250 260 270 280 WLLSIDLKGW LPKTIINQVL SQTQVDFANH LRKRLESSPA PEARC

References

[1]

"Human chorionic gonadotropin induces an inverse regulation of steroidogenic acute regulatory protein messenger ribonucleic acid in theca interna and granulosa cells of equine preovulatory follicles." Kerban A., Boerboom D., Sirois J. Endocrinology 140:667-674(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Follicular cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF031697 mRNA. Translation: AAC04704.1. AF031696 mRNA. Translation: AAC04703.1.
RefSeq	NP_001075269.1. NM_001081800.1.
UniGene	Eca.12877.
3D structure databases
ProteinModelPortal	O46689.
ModBase	Search...
Protein-protein interaction databases
STRING	9796.ENSECAP00000010699.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100009707.
KEGG	ecb:100009707.
Organism-specific databases
CTD	6770.
Phylogenomic databases
eggNOG	NOG239518.
HOGENOM	HOG000142452.
HOVERGEN	HBG010529.
InParanoid	O46689.
OrthoDB	EOG4JWVF2.
Enzyme and pathway databases
UniPathway	UPA00296.
Family and domain databases
Gene3D	3.30.530.20. 1 hit.
InterPro	IPR000799. StAR. IPR023393. START-like_dom. IPR002913. START_lipid-bd_dom. [Graphical view]
Pfam	PF01852. START. 1 hit. [Graphical view]
PRINTS	PR00978. STARPROTEIN.
SMART	SM00234. START. 1 hit. [Graphical view]
PROSITE	PS50848. START. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STAR_HORSE

Accession

Primary (citable) accession number: O46689

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program