Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Somatostatin

Gene

SST

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 2 chains:
Gene namesi
Name:SST
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
PropeptideiPRO_000003310325 – 88By similarityAdd BLAST64
PeptideiPRO_000003310489 – 116Somatostatin-28Add BLAST28
PeptideiPRO_0000033105103 – 116Somatostatin-14Add BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00510000047914.
HOVERGENiHBG017816.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG091G157X.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALSIVLALG GVTGAPSDPR LRQFLQKSLA AAAGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,689
Last modified:June 1, 1998 - v1
Checksum:iC18F17E31A3718DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031488 mRNA. Translation: AAC04697.1.
Y15267 mRNA. Translation: CAA75556.1.
PIRiA61322.
RefSeqiNP_001009196.1. NM_001009196.1.
UniGeneiOar.609.

Genome annotation databases

EnsembliENSOART00000022319; ENSOARP00000022014; ENSOARG00000020492.
GeneIDi443006.
KEGGioas:443006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031488 mRNA. Translation: AAC04697.1.
Y15267 mRNA. Translation: CAA75556.1.
PIRiA61322.
RefSeqiNP_001009196.1. NM_001009196.1.
UniGeneiOar.609.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000022319; ENSOARP00000022014; ENSOARG00000020492.
GeneIDi443006.
KEGGioas:443006.

Organism-specific databases

CTDi6750.

Phylogenomic databases

GeneTreeiENSGT00510000047914.
HOVERGENiHBG017816.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG091G157X.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMS_SHEEP
AccessioniPrimary (citable) accession number: O46688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.