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Protein

Ovarian cancer G-protein coupled receptor 1

Gene

GPR68

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-373076. Class A/1 (Rhodopsin-like receptors).
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian cancer G-protein coupled receptor 1
Alternative name(s):
G protein-coupled receptor RGR1
Short name:
bRGR1
G-protein coupled receptor 68
Gene namesi
Name:GPR68
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 5714CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9618ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13720CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 18325ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini205 – 22925CytoplasmicSequence analysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini251 – 26919ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 36171CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Ovarian cancer G-protein coupled receptor 1PRO_0000383597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO46685.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008858.

Structurei

3D structure databases

ProteinModelPortaliO46685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiO46685.
KOiK08408.
OMAiDRHRVCF.
OrthoDBiEOG7992QK.
TreeFamiTF331803.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005389. OGR1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01564. OGR1RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNITADNTS MNCDIDHTIH QTLAPVVYVM VLVVGFPANC LSLYYGYLQI
60 70 80 90 100
KARNELGVYL CNLTVADLFY ICSLPFWLQY VLQHDHWSHD DLSCQVCGIL
110 120 130 140 150
LYENIYISVG FLCCISIDRY LAVAHPFRFH QFRTLKAAMG VSALIWVKEL
160 170 180 190 200
LTSIYFLMHE EVVEDADRHR VCFEHYPLEP RQRGINYYRF LVGFLFPICL
210 220 230 240 250
LLASYRGILR AVRRSHGTQK SRKDQIQRLV LSTVVIFLAC FLPYHVLLLV
260 270 280 290 300
RSLWESSCDF AKGIFNAYHF SLLLTSFNCV ADPVLYCFVS ETTHRDLARL
310 320 330 340 350
RGACLAFLTC ARTGRAREAY PLGAPEASGK SEDPEVLTRL HPAFQTPHPP
360
GMGGSPAGGL S
Length:361
Mass (Da):40,906
Last modified:June 1, 1998 - v1
Checksum:i4802E77C9A45DEE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88366 mRNA. Translation: AAC05611.1.
U88367 mRNA. Translation: AAC05612.1.
PIRiJC5653.
RefSeqiNP_776754.1. NM_174329.2.
UniGeneiBt.4597.

Genome annotation databases

EnsembliENSBTAT00000008858; ENSBTAP00000008858; ENSBTAG00000006738.
GeneIDi281799.
KEGGibta:281799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88366 mRNA. Translation: AAC05611.1.
U88367 mRNA. Translation: AAC05612.1.
PIRiJC5653.
RefSeqiNP_776754.1. NM_174329.2.
UniGeneiBt.4597.

3D structure databases

ProteinModelPortaliO46685.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008858.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO46685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008858; ENSBTAP00000008858; ENSBTAG00000006738.
GeneIDi281799.
KEGGibta:281799.

Organism-specific databases

CTDi8111.

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiO46685.
KOiK08408.
OMAiDRHRVCF.
OrthoDBiEOG7992QK.
TreeFamiTF331803.

Enzyme and pathway databases

ReactomeiR-BTA-373076. Class A/1 (Rhodopsin-like receptors).
R-BTA-416476. G alpha (q) signalling events.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005389. OGR1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01564. OGR1RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a bovine renal G-protein coupled receptor gene (bRGR): regulation of bRGR mRNA levels by amino acid availability."
    Ferrer-Martinez A., Felipe A., Mata J.F., Casado F.J., Pastor-Anglada M.
    Biochem. Biophys. Res. Commun. 238:107-112(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiOGR1_BOVIN
AccessioniPrimary (citable) accession number: O46685
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.