Reviewed, UniProtKB/Swiss-Prot O46680 (TGFR1_BOVIN)

Names and origin

Protein names

Recommended name:
    TGF-beta receptor type-1
    EC=2.7.11.30
Alternative name(s):
    Transforming growth factor-beta receptor type I
      Short name=TGF-beta receptor type I
    TGF-beta type I receptor
    TbetaR-I
    TGFR-1

Gene names

Name:

TGFBR1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subunit structure	Interacts with CD109. The unphosphorylated protein interacts with FKBP1A and is stabilized the inactive conformation. Phosphorylation of the GS region abrogates FKBP1A binding. Interacts with SMAD2 when phosphorylated on several residues in the GS region By similarity.
Subcellular location	Membrane; Single-pass type I membrane proteinBy similarity.
Post-translational modification	Phosphorylated at basal levels in the absence of ligand binding. Activated by multiple phosphorylation, mainly in the GS region By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: AgBase
Molecular function	transforming growth factor beta receptor activity, type I Inferred from sequence or structural similarity. Source: AgBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 499	470	TGF-beta receptor type-1
Regions
	Topological domain	30 – 122	93	Extracellular Potential
	Transmembrane	123 – 143	21	Potential
	Topological domain	144 – 499	356	Cytoplasmic Potential
	Domain	171 – 200	30	GS
	Domain	201 – 491	291	Protein kinase
	Nucleotide binding	207 – 215	9	ATP By similarity
Sites
	Active site	329	1	Proton acceptor By similarity
	Binding site	228	1	ATP By similarity
Amino acid modifications
	Modified residue	181	1	Phosphothreonine By similarity
	Modified residue	182	1	Phosphothreonine By similarity
	Modified residue	183	1	Phosphoserine By similarity
	Modified residue	185	1	Phosphoserine By similarity
	Modified residue	187	1	Phosphoserine By similarity
	Glycosylation	41	1	N-linked (GlcNAc...) Potential
	Disulfide bond	32 ↔ 50		By similarity
	Disulfide bond	34 ↔ 37		By similarity
	Disulfide bond	44 ↔ 67		By similarity
	Disulfide bond	82 ↔ 96		By similarity
	Disulfide bond	97 ↔ 102		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O46680-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 7FA311693CA938CD	FASTA	499	55,814
	10 20 30 40 50 60 MEAAAATPRP RLFLLMLAAA ATLVPEATPL QCFCHLCTKD NFTCVTDGLC FVSVTETTDK 70 80 90 100 110 120 VIHNSMCIAE IDLIPRDRPF VCAPSSKTGS ITTTYCCNQD HCNKIELPTV GKPSSGLGPV 130 140 150 160 170 180 ELAAVIAGPV CFVCISLMLM VYICHNRTVI HHRVPNEEDP SLDRPFISEG TTLKDLIYDM 190 200 210 220 230 240 TTSGSGSGLP LLVQRTIART IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR 250 260 270 280 290 300 EAEIYQTVML RHENILGFIA ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK 310 320 330 340 350 360 LALSTASGLA HLHMEIVGTQ GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT 370 380 390 400 410 420 IDIAPNHRVG TKRYMAPEVL DDSINMKHFE SFKRADIYAM GLVFWEVARR CSIGGIHEDY 430 440 450 460 470 480 QLPYYDLVPS DPSVEEMRKV VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT 490 ALRIKKTLSQ LSQQEGIKM

References

[1]

"Molecular cloning, genetic mapping, and developmental expression of a bovine transforming growth factor beta (TGF-beta) type I receptor." Roelen B.A.J., Van Eijk M.J.T., Van Rooijen M.A., Bevers M.M., Larson J.H., Lewin H.A., Mummery C.L. Mol. Reprod. Dev. 49:1-9(1998) [PubMed: 9406190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U97485 mRNA. Translation: AAC02717.1.
RefSeq	NP_777046.1.
UniGene	Bt.91785
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
SMR	O46680. Positions 197-499.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000018035. Bos taurus. [Contig view]
GeneID	282382.
KEGG	bta:282382.
Phylogenomic databases
HOVERGEN	O46680.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

TGFR1_BOVIN

Accession

Primary (citable) accession number: O46680

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 1, 1998
Last modified:	July 22, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)