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Protein

Growth-regulated protein homolog alpha

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated protein homolog alpha
Short name:
GRO-alpha
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 10474Growth-regulated protein homolog alphaPRO_0000005058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 66By similarity
Disulfide bondi42 ↔ 82By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO46676.
PRIDEiO46676.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055252.

Structurei

3D structure databases

ProteinModelPortaliO46676.
SMRiO46676. Positions 37-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK05505.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAATAAAP RLLRAAMLFL LLVAAGRRAA GAPVVNELRC QCLQTLQGIH
60 70 80 90 100
LKNIQSVKVT TPGPHCDQTE VIASLKTGQE VCLNPTAPMV KKIIDKMLNK

ASAN
Length:104
Mass (Da):10,984
Last modified:June 1, 1998 - v1
Checksum:i1002CAC064DB1F76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95812 mRNA. Translation: AAB93928.1.
PIRiS50035.
RefSeqiNP_783631.1. NM_175700.1.
UniGeneiBt.611.

Genome annotation databases

GeneIDi281212.
KEGGibta:281212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95812 mRNA. Translation: AAB93928.1.
PIRiS50035.
RefSeqiNP_783631.1. NM_175700.1.
UniGeneiBt.611.

3D structure databases

ProteinModelPortaliO46676.
SMRiO46676. Positions 37-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055252.

Proteomic databases

PaxDbiO46676.
PRIDEiO46676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281212.
KEGGibta:281212.

Organism-specific databases

CTDi281212.

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK05505.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of novel GRO genes and a phylogenetic analysis of the CXC chemokine subfamily in mammals."
    Modi W.S., Yoshimura T.
    Mol. Biol. Evol. 16:180-193(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGROA_BOVIN
AccessioniPrimary (citable) accession number: O46676
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.