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Protein

Growth-regulated protein homolog alpha

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated protein homolog alpha
Short name:
GRO-alpha
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000505831 – 104Growth-regulated protein homolog alphaAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 66By similarity
Disulfide bondi42 ↔ 82By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO46676.
PRIDEiO46676.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO46676.
SMRiO46676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK05505.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAATAAAP RLLRAAMLFL LLVAAGRRAA GAPVVNELRC QCLQTLQGIH
60 70 80 90 100
LKNIQSVKVT TPGPHCDQTE VIASLKTGQE VCLNPTAPMV KKIIDKMLNK

ASAN
Length:104
Mass (Da):10,984
Last modified:June 1, 1998 - v1
Checksum:i1002CAC064DB1F76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95812 mRNA. Translation: AAB93928.1.
PIRiS50035.
RefSeqiNP_783631.1. NM_175700.1.
UniGeneiBt.611.

Genome annotation databases

GeneIDi281212.
KEGGibta:281212.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGROA_BOVIN
AccessioniPrimary (citable) accession number: O46676
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families