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O46660

- NOS2_MACMU

UniProt

O46660 - NOS2_MACMU

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Protein
Nitric oxide synthase, inducible
Gene
NOS2
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. INOS and NO may contribute to simian immunodeficiency virus (SIV)-induced central nervous system disease. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 By similarity.

Catalytic activityi

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

Cofactori

Heme group By similarity.
Binds 1 FAD By similarity.
Binds 1 FMN By similarity.
Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme By similarity.

Enzyme regulationi

Regulated by calcium/calmodulin By similarity.

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nitric-oxide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. nitric oxide biosynthetic process Source: InterPro
  2. peptidyl-cysteine S-nitrosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, Calmodulin-binding, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide synthase, inducible (EC:1.14.13.39)
Alternative name(s):
Inducible NO synthase
Short name:
Inducible NOS
Short name:
iNOS
NOS type II
Peptidyl-cysteine S-nitrosylase NOS2
Gene namesi
Name:NOS2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›162›162Nitric oxide synthase, inducible
PRO_0000170933Add
BLAST

Expressioni

Inductioni

By lipopolysaccharide (LPS).

Interactioni

Subunit structurei

Homodimer. Binds SLC9A3R1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliO46660.
SMRiO46660. Positions 63-162.

Family & Domainsi

Sequence similaritiesi

Belongs to the NOS family.

Family and domain databases

Gene3Di3.90.340.10. 1 hit.
InterProiIPR004030. NOS_N.
[Graphical view]
SUPFAMiSSF56512. SSF56512. 1 hit.

Sequencei

Sequence statusi: Fragment.

O46660-1 [UniParc]FASTAAdd to Basket

« Hide

GKDINNNMEK AACATSSLVT QDDLQYHSLS KQQNESPQPL VGTGKKSPES    50
LVKPDATPLS SPRHVRIKNW GSGMTFQDTL HHKAKGILTC RSKSCLGSIM 100
TPKSLTRGPR DKPTPPDELL PQAIEFVNLS LEISVQDQIP PVCNDCQYYG 150
SFKEAKIEEH LA 162
Length:162
Mass (Da):17,813
Last modified:June 1, 1998 - v1
Checksum:i0457464D32287065
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei162 – 1621

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31907 mRNA. Translation: AAC39525.1.
UniGeneiMmu.3443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31907 mRNA. Translation: AAC39525.1 .
UniGenei Mmu.3443.

3D structure databases

ProteinModelPortali O46660.
SMRi O46660. Positions 63-162.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.90.340.10. 1 hit.
InterProi IPR004030. NOS_N.
[Graphical view ]
SUPFAMi SSF56512. SSF56512. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease."
    Lane T.E., Buchmeier M.J., Watry D.D., Fox H.S.
    Mol. Med. 2:27-37(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Microglia.

Entry informationi

Entry nameiNOS2_MACMU
AccessioniPrimary (citable) accession number: O46660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3