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O46660

- NOS2_MACMU

UniProt

O46660 - NOS2_MACMU

Protein

Nitric oxide synthase, inducible

Gene

NOS2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. INOS and NO may contribute to simian immunodeficiency virus (SIV)-induced central nervous system disease. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 By similarity.By similarity

    Catalytic activityi

    2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

    Cofactori

    Heme group.By similarity
    Binds 1 FAD.By similarity
    Binds 1 FMN.By similarity
    Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme By similarity.By similarity

    Enzyme regulationi

    Regulated by calcium/calmodulin.By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nitric-oxide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nitric oxide biosynthetic process Source: InterPro
    2. peptidyl-cysteine S-nitrosylation Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Calcium, Calmodulin-binding, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nitric oxide synthase, inducible (EC:1.14.13.39)
    Alternative name(s):
    Inducible NO synthase
    Short name:
    Inducible NOS
    Short name:
    iNOS
    NOS type II
    Peptidyl-cysteine S-nitrosylase NOS2
    Gene namesi
    Name:NOS2
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›162›162Nitric oxide synthase, induciblePRO_0000170933Add
    BLAST

    Expressioni

    Inductioni

    By lipopolysaccharide (LPS).

    Interactioni

    Subunit structurei

    Homodimer. Binds SLC9A3R1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO46660.
    SMRiO46660. Positions 63-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NOS family.Curated

    Family and domain databases

    Gene3Di3.90.340.10. 1 hit.
    InterProiIPR004030. NOS_N.
    [Graphical view]
    SUPFAMiSSF56512. SSF56512. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    O46660-1 [UniParc]FASTAAdd to Basket

    « Hide

    GKDINNNMEK AACATSSLVT QDDLQYHSLS KQQNESPQPL VGTGKKSPES    50
    LVKPDATPLS SPRHVRIKNW GSGMTFQDTL HHKAKGILTC RSKSCLGSIM 100
    TPKSLTRGPR DKPTPPDELL PQAIEFVNLS LEISVQDQIP PVCNDCQYYG 150
    SFKEAKIEEH LA 162
    Length:162
    Mass (Da):17,813
    Last modified:June 1, 1998 - v1
    Checksum:i0457464D32287065
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei162 – 1621

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31907 mRNA. Translation: AAC39525.1.
    UniGeneiMmu.3443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31907 mRNA. Translation: AAC39525.1 .
    UniGenei Mmu.3443.

    3D structure databases

    ProteinModelPortali O46660.
    SMRi O46660. Positions 63-162.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.90.340.10. 1 hit.
    InterProi IPR004030. NOS_N.
    [Graphical view ]
    SUPFAMi SSF56512. SSF56512. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease."
      Lane T.E., Buchmeier M.J., Watry D.D., Fox H.S.
      Mol. Med. 2:27-37(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Microglia.

    Entry informationi

    Entry nameiNOS2_MACMU
    AccessioniPrimary (citable) accession number: O46660
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3