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Protein

Alcohol dehydrogenase class-2 isozyme 2

Gene

ADH2-2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi176Zinc 1; catalyticBy similarity1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 210NADBy similarity6
Nucleotide bindingi298 – 300NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-2 isozyme 2 (EC:1.1.1.1)
Gene namesi
Name:ADH2-2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606851 – 379Alcohol dehydrogenase class-2 isozyme 2Add BLAST379

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021279.

Structurei

3D structure databases

ProteinModelPortaliO46650.
SMRiO46650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiO46650.
KOiK13980.
OMAiAVLWERN.
OrthoDBiEOG091G08N3.
TreeFamiTF300429.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR028632. Zinc_ADH_II.
PANTHERiPTHR43880:SF11. PTHR43880:SF11. 1 hit.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

O46650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKGKVIKC KAAIAWEAGK PLSIEEVEVA PPKAHEVRVQ IIAASVCRSD
60 70 80 90 100
TYVINPAFKE GLLPVILGHE CAGIVESVGP GVNNFKPGDK VIPLYVPHCR
110 120 130 140 150
KCKFCQSPLT NFCTKFSEHK NPIIEQELMD DKTSRFTCKG KSIYHFLGIS
160 170 180 190 200
AFSQYTVVKD INLAKIDDDA NLKRVCLIGC GFSTGYGAAI NDAKVTPGST
210 220 230 240 250
CAVFGLGGVG LSAVIGCKTA GASRIIAVDI NSDKFAKAKA LGATDCLNPR
260 270 280 290 300
ELNKPVQDVI VEMTNGGVDF AIDCAGGSEV MKATVDCTTV GWGSCTFVGV
310 320 330 340 350
NVNDKGLTIS PVELILGRTL RGSSFGGWDV DTVPKLVSDY KNGKFNLEAL
360 370
VTHTLPFEKI NEALDLLKQG KSIRTILIY
Length:379
Mass (Da):40,497
Last modified:January 23, 2007 - v2
Checksum:iA650C7DEA2337777
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002389 mRNA. Translation: CAA05363.1.
RefSeqiNP_001171758.1. NM_001184829.1.
UniGeneiOcu.3232.

Genome annotation databases

EnsembliENSOCUT00000029300; ENSOCUP00000021279; ENSOCUG00000023401.
GeneIDi100345521.
KEGGiocu:100345521.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADHQ_RABIT
AccessioniPrimary (citable) accession number: O46650
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families