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Protein

Alcohol dehydrogenase class-2 isozyme 2

Gene

ADH2-2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi176Zinc 1; catalyticBy similarity1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 210NADBy similarity6
Nucleotide bindingi298 – 300NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-2 isozyme 2 (EC:1.1.1.1)
Gene namesi
Name:ADH2-2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 15

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606851 – 379Alcohol dehydrogenase class-2 isozyme 2Add BLAST379

Proteomic databases

PRIDEiO46650

Expressioni

Gene expression databases

BgeeiENSOCUG00000023401

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021279

Structurei

3D structure databases

ProteinModelPortaliO46650
SMRiO46650
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiO46650
KOiK13980
OMAiYGGMNPR
OrthoDBiEOG091G08N3
TreeFamiTF300429

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028632 Zinc_ADH_II
PANTHERiPTHR43880:SF14 PTHR43880:SF14, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

O46650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKGKVIKC KAAIAWEAGK PLSIEEVEVA PPKAHEVRVQ IIAASVCRSD
60 70 80 90 100
TYVINPAFKE GLLPVILGHE CAGIVESVGP GVNNFKPGDK VIPLYVPHCR
110 120 130 140 150
KCKFCQSPLT NFCTKFSEHK NPIIEQELMD DKTSRFTCKG KSIYHFLGIS
160 170 180 190 200
AFSQYTVVKD INLAKIDDDA NLKRVCLIGC GFSTGYGAAI NDAKVTPGST
210 220 230 240 250
CAVFGLGGVG LSAVIGCKTA GASRIIAVDI NSDKFAKAKA LGATDCLNPR
260 270 280 290 300
ELNKPVQDVI VEMTNGGVDF AIDCAGGSEV MKATVDCTTV GWGSCTFVGV
310 320 330 340 350
NVNDKGLTIS PVELILGRTL RGSSFGGWDV DTVPKLVSDY KNGKFNLEAL
360 370
VTHTLPFEKI NEALDLLKQG KSIRTILIY
Length:379
Mass (Da):40,497
Last modified:January 23, 2007 - v2
Checksum:iA650C7DEA2337777
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002389 mRNA Translation: CAA05363.1
RefSeqiNP_001171758.1, NM_001184829.1
UniGeneiOcu.3232

Genome annotation databases

EnsembliENSOCUT00000029300; ENSOCUP00000021279; ENSOCUG00000023401
GeneIDi100345521
KEGGiocu:100345521

Similar proteinsi

Entry informationi

Entry nameiADHQ_RABIT
AccessioniPrimary (citable) accession number: O46650
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health