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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Equus burchelli (Plains zebra) (Equus quagga)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:CGA
OrganismiEquus burchelli (Plains zebra) (Equus quagga)
Taxonomic identifieri9790 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001163825 – 120Glycoprotein hormones alpha chainAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi87 ↔ 115By similarity
Glycosylationi106N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO46642.
SMRiO46642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000452.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiView protein in Pfam
PF00236. Hormone_6. 1 hit.
PRINTSiPR00274. GLYCOHORMONE.
SMARTiView protein in SMART
SM00067. GHA. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKHAAV ILATLSVFLH ILHSFPDGEF TTQDCPECKL KVNKYFSKLG
60 70 80 90 100
VPIYQCMGCC FSRAYPTPAR SRKTMLVPKN ITSEATCCVA KAFIRVTLMG
110 120
NIRLENHTQC YCSTCYHHKI
Length:120
Mass (Da):13,720
Last modified:June 1, 1998 - v1
Checksum:i2A09BC817945A9ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16326 mRNA. Translation: CAA76177.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLHA_EQUBU
AccessioniPrimary (citable) accession number: O46642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: May 10, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families