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Protein

Amine sulfotransferase

Gene

SULT3A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the N-sulfonation of amines (PTHP, aniline, 4-chloroaniline, 2-naphthylamine).1 Publication

Catalytic activityi

3'-phosphoadenylyl sulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101Proton acceptorBy similarity1
Binding sitei123PAPSBy similarity1
Binding sitei131PAPSBy similarity1
Binding sitei186PAPSBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 51PAPSBy similarity6
Nucleotide bindingi220 – 225PAPSBy similarity6
Nucleotide bindingi252 – 254PAPSBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.8.2.3. 1749.

Names & Taxonomyi

Protein namesi
Recommended name:
Amine sulfotransferase (EC:2.8.2.3)
Alternative name(s):
AST-RB1
Sulfotransferase 3A1
Short name:
ST3A1
Gene namesi
Name:SULT3A1
Synonyms:ST3A1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851661 – 301Amine sulfotransferaseAdd BLAST301

Expressioni

Tissue specificityi

Expressed in male liver.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022723.

Structurei

3D structure databases

ProteinModelPortaliO46640.
SMRiO46640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiO46640.
KOiK16949.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
PfamiView protein in Pfam
PF00685. Sulfotransfer_1. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O46640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSRKYLLN FKGCNFERTL VDMKILEKLD DFEIRDDDVF VITYPKSGTV
60 70 80 90 100
WTQQILSLIY FEGHRNRTEK WDTLDRVPFL EYNIRKVDIE NRPSPRLFAS
110 120 130 140 150
HLPYYLAPKS LKNNKAKIIY VYRNPKDVLI SFFHFSNMVV KLEASNTLEN
160 170 180 190 200
FMEKFLDGKV VGSIWFDHIR GWYEHKNDFN ILFMMYEDMK KDLRSSILKI
210 220 230 240 250
SSFLEKDLSE EEVDAIVRQA TFENMKFIPQ ANYNNILSNE IGRRHNEGAF
260 270 280 290 300
LRKGAVGDWK HHMTVEQSER FDRIFQEEMK DFPLKFIWDL NDEANSNHSA

K
Length:301
Mass (Da):35,943
Last modified:June 1, 1998 - v1
Checksum:iA28EE738D54C3C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86219 mRNA. Translation: BAA24994.1.
PIRiJW0078.
RefSeqiNP_001075679.1. NM_001082210.2.
UniGeneiOcu.2196.

Genome annotation databases

GeneIDi100009006.
KEGGiocu:100009006.

Similar proteinsi

Entry informationi

Entry nameiST3A1_RABIT
AccessioniPrimary (citable) accession number: O46640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 1998
Last modified: April 12, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families