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Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:TRHR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 51Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini52 – 61CytoplasmicSequence analysis10
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 99ExtracellularSequence analysisAdd BLAST16
Transmembranei100 – 121Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini122 – 144CytoplasmicSequence analysisAdd BLAST23
Transmembranei145 – 168Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini169 – 193ExtracellularSequence analysisAdd BLAST25
Transmembranei194 – 215Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini216 – 266CytoplasmicSequence analysisAdd BLAST51
Transmembranei267 – 288Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini289 – 296ExtracellularSequence analysis8
Transmembranei297 – 319Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini320 – 398CytoplasmicSequence analysisAdd BLAST79

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701861 – 398Thyrotropin-releasing hormone receptorAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO46639.
PRIDEiO46639.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019997.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026634.

Structurei

3D structure databases

ProteinModelPortaliO46639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiO46639.
KOiK04282.
OMAiEYQVVTI.
OrthoDBiEOG091G08BE.
TreeFamiTF326170.

Family and domain databases

CDDicd14995. 7tmA_TRH-R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
PANTHERiPTHR24243:SF115. PTHR24243:SF115. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O46639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENETGSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV
60 70 80 90 100
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC
110 120 130 140 150
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW
160 170 180 190 200
AFTSIYCMLW FFLLDLNIST YKDAIVVSCG YKISRNYYSP IYLMDFGVFY
210 220 230 240 250
VVPMILATVL YGFIARILFL NPIPSDPKEN SNMWKNDSTH QNKNLNSKTS
260 270 280 290 300
NRYFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
310 320 330 340 350
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PVEKPANYSV
360 370 380 390
ALSYSVIKES DRFSTELDDV TVTDTYLSAT KVSFDDTCLA SEITFNQS
Length:398
Mass (Da):45,165
Last modified:June 1, 1998 - v1
Checksum:iD9AF4B211A5701B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83964 Genomic DNA. Translation: BAA24069.1.
RefSeqiNP_776628.1. NM_174203.1.
XP_015329974.1. XM_015474488.1.
UniGeneiBt.45042.

Genome annotation databases

EnsembliENSBTAT00000026634; ENSBTAP00000026634; ENSBTAG00000019997.
GeneIDi281549.
KEGGibta:281549.

Similar proteinsi

Entry informationi

Entry nameiTRFR_BOVIN
AccessioniPrimary (citable) accession number: O46639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families