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Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:TRHR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 5123Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 6110CytoplasmicSequence analysis
Transmembranei62 – 8322Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini84 – 9916ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12122Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini122 – 14423CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16824Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 19325ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21522Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 26651CytoplasmicSequence analysisAdd
BLAST
Transmembranei267 – 28822Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini289 – 2968ExtracellularSequence analysis
Transmembranei297 – 31923Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 39879CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Thyrotropin-releasing hormone receptorPRO_0000070186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO46639.
PRIDEiO46639.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026634.

Structurei

3D structure databases

ProteinModelPortaliO46639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiO46639.
KOiK04282.
OMAiKLCNCKQ.
OrthoDBiEOG091G08BE.
TreeFamiTF326170.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENETGSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV
60 70 80 90 100
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC
110 120 130 140 150
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW
160 170 180 190 200
AFTSIYCMLW FFLLDLNIST YKDAIVVSCG YKISRNYYSP IYLMDFGVFY
210 220 230 240 250
VVPMILATVL YGFIARILFL NPIPSDPKEN SNMWKNDSTH QNKNLNSKTS
260 270 280 290 300
NRYFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
310 320 330 340 350
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PVEKPANYSV
360 370 380 390
ALSYSVIKES DRFSTELDDV TVTDTYLSAT KVSFDDTCLA SEITFNQS
Length:398
Mass (Da):45,165
Last modified:June 1, 1998 - v1
Checksum:iD9AF4B211A5701B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83964 Genomic DNA. Translation: BAA24069.1.
RefSeqiNP_776628.1. NM_174203.1.
XP_015329974.1. XM_015474488.1.
UniGeneiBt.45042.

Genome annotation databases

EnsembliENSBTAT00000026634; ENSBTAP00000026634; ENSBTAG00000019997.
GeneIDi281549.
KEGGibta:281549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83964 Genomic DNA. Translation: BAA24069.1.
RefSeqiNP_776628.1. NM_174203.1.
XP_015329974.1. XM_015474488.1.
UniGeneiBt.45042.

3D structure databases

ProteinModelPortaliO46639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026634.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO46639.
PRIDEiO46639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026634; ENSBTAP00000026634; ENSBTAG00000019997.
GeneIDi281549.
KEGGibta:281549.

Organism-specific databases

CTDi7201.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiO46639.
KOiK04282.
OMAiKLCNCKQ.
OrthoDBiEOG091G08BE.
TreeFamiTF326170.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRFR_BOVIN
AccessioniPrimary (citable) accession number: O46639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.