Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

  • Secreted

  • Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152531 – 108By similarityAdd BLAST108
ChainiPRO_0000015254109 – 265Interleukin-1 alphaAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO46612.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038305.

Structurei

3D structure databases

ProteinModelPortaliO46612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiO46612.
KOiK04383.
TreeFamiTF300203.

Family and domain databases

InterProiView protein in InterPro
IPR003295. IL-1_alpha.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR10078:SF67. PTHR10078:SF67. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENEE YSSEIDHLSL NQKSFYDMSC DPLHEDCMSL
60 70 80 90 100
STSEISKTSQ LTFKENVVVV AANGKILKKR RLSLSQFITD DDLEGIANDT
110 120 130 140 150
EEVIMKPRSV AYNFHNNEKY NYIRIIKSQF ILNDNLNQSI VRQTGGNYLM
160 170 180 190 200
TAALQNLDDA VKFDMGAYTS EDSKLPVTLR ISKTRLFVSA QNEDEPVLLK
210 220 230 240 250
EMPETPKTIR DETNLLFFWE RHGSKHYFKS VAQPKLFIAT QERKLVHMAR
260
GQPSITDFRL LETQP
Length:265
Mass (Da):30,522
Last modified:June 1, 1998 - v1
Checksum:iCC1D316CA37173A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95G → D in ABJ51907 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047011 mRNA. Translation: AAC03066.1.
DQ923806 mRNA. Translation: ABJ51907.1.
RefSeqiNP_001003157.2. NM_001003157.2.
UniGeneiCfa.3645.

Genome annotation databases

GeneIDi403782.
KEGGicfa:403782.

Similar proteinsi

Entry informationi

Entry nameiIL1A_CANLF
AccessioniPrimary (citable) accession number: O46612
Secondary accession number(s): Q006K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: May 10, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families