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Protein

Hepatitis A virus cellular receptor 1

Gene

HAVCR1

Organism
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of simian hepatitis A virus (SHAV) infection, functions as a cell-surface receptor for the virus.By similarity1 Publication

GO - Molecular functioni

  • virus receptor activity Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1
Short name:
HAVcr-1
Alternative name(s):
T-cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
T-cell immunoglobulin mucin receptor 1
Short name:
TIM-1
T-cell membrane protein 1
Gene namesi
Name:HAVCR1
Synonyms:TIM1, TIMD1
OrganismiChlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Taxonomic identifieri9534 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 397ExtracellularSequence analysisAdd BLAST373
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 478CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • motile cilium Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500014688225 – 478Hepatitis A virus cellular receptor 1Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 110PROSITE-ProRule annotation
Disulfide bondi51 ↔ 62PROSITE-ProRule annotation
Disulfide bondi57 ↔ 109PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...)1 Publication1
Glycosylationi87N-linked (GlcNAc...)1 Publication1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Binds to immunoglobulin A (IgA). Associtation with IgA enhances hepatitis A virus-receptor interaction (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO46598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 126Ig-like V-typeAdd BLAST102
Repeati148 – 15518
Repeati156 – 16126
Repeati162 – 16736
Repeati168 – 17346
Repeati174 – 17956
Repeati180 – 18566
Repeati186 – 19176
Repeati192 – 19786
Repeati198 – 20194
Repeati202 – 207106
Repeati208 – 211114
Repeati212 – 217126
Repeati218 – 221134
Repeati222 – 227146
Repeati228 – 233156
Repeati234 – 239166
Repeati240 – 245176
Repeati246 – 251186
Repeati252 – 257196
Repeati258 – 263206
Repeati264 – 268215
Repeati269 – 273225
Repeati274 – 279236
Repeati280 – 285246
Repeati286 – 291256
Repeati292 – 297266
Repeati298 – 303276
Repeati304 – 309286

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni148 – 30928 X 6 AA approximate tandem repeats of L-P-[MT]-T-[MT]-TAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 369Thr-richAdd BLAST235

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform long (identifier: O46598-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADPIMHLQV VILSLILHLA DSVADSVNVD GVAGLSITLP CRYNGAITSM
60 70 80 90 100
CWNRGTCSVF SCPDGIVWTN GTHVTYRKET RYKLLGNLSR RDVSLTIANT
110 120 130 140 150
AVSDSGIYCC RVKHSGWFND MKITISLKIG PPRVTIPIVR TVRTSTTVPT
160 170 180 190 200
TTTTTLPTTT TLPTTTTLPT TMTLPTTTTL PMTTTLPTTT TVPMTTTLPT
210 220 230 240 250
TLPTTTTLPT TLPTTTTLPT TLPTTTTLPT TMTLPMTTTL PTTTTLPTTT
260 270 280 290 300
TLPTTTTLPT TTTLPTTTLP TMTLPTTTTL PTTMTLPMTT TLPTTTTLPT
310 320 330 340 350
TTTLPTTTMV STFVPPTPLP MQDHEPVATS PSSAQPAETH PVTLLGATRT
360 370 380 390 400
QPTSSPLYSY TTDGSDTVTE SSDGLWNNNQ TQLSPEHSPQ MVNTTEGIYA
410 420 430 440 450
GVCISVLVLL AVLGVVIAKK YFFKKEIQQL SVSFSNHQFK TLQNAVKKEV
460 470
HAEDNIYIEN NLYAMNQDPV VLFESLRP
Length:478
Mass (Da):51,490
Last modified:November 13, 2007 - v2
Checksum:iA2794438E8BAC379
GO
Isoform short (identifier: O46598-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.

Show »
Length:473
Mass (Da):50,963
Checksum:i55FD3D33C874BC0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22S → F in BAA21556 (PubMed:9225030).Curated1
Sequence conflicti53N → H in AAC39771 (PubMed:9621093).Curated1
Sequence conflicti53N → H in AAC39772 (PubMed:9621093).Curated1
Sequence conflicti53N → H in AAC39773 (PubMed:9621093).Curated1
Sequence conflicti136I → T in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti153 – 154Missing in CAA66906 (PubMed:8861957).Curated2
Sequence conflicti172M → T in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti172M → T in BAA21556 (PubMed:9225030).Curated1
Sequence conflicti176T → M in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti194M → T in BAA21556 (PubMed:9225030).Curated1
Sequence conflicti194M → T in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti196 – 209Missing in CAA66906 (PubMed:8861957).CuratedAdd BLAST14
Sequence conflicti207Missing in BAA21556 (PubMed:9225030).Curated1
Sequence conflicti212 – 215Missing in AAC39771 (PubMed:9621093).Curated4
Sequence conflicti212 – 215Missing in AAC39772 (PubMed:9621093).Curated4
Sequence conflicti224T → M in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti232M → R in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti236M → T in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti240L → I in AAC39771 (PubMed:9621093).Curated1
Sequence conflicti240L → I in AAC39772 (PubMed:9621093).Curated1
Sequence conflicti243T → M in BAA21556 (PubMed:9225030).Curated1
Sequence conflicti244T → M in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti248T → M in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti257 – 268Missing in BAA21556 (PubMed:9225030).CuratedAdd BLAST12
Sequence conflicti283 – 290TMTLPMTT → MM in CAA66906 (PubMed:8861957).Curated8
Sequence conflicti323D → N in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti323D → N in BAA21556 (PubMed:9225030).Curated1
Sequence conflicti334A → P in CAA66906 (PubMed:8861957).Curated1
Sequence conflicti334A → P in BAA21556 (PubMed:9225030).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0290861 – 5Missing in isoform short. 3 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98252 mRNA. Translation: CAA66906.1.
D88585 mRNA. Translation: BAA21556.1.
AF043446 mRNA. Translation: AAC39771.1.
AF043447 mRNA. Translation: AAC39772.1.
AF043448 mRNA. Translation: AAC39773.1.
AF043449 mRNA. Translation: AAC39774.1.
PIRiS71754.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98252 mRNA. Translation: CAA66906.1.
D88585 mRNA. Translation: BAA21556.1.
AF043446 mRNA. Translation: AAC39771.1.
AF043447 mRNA. Translation: AAC39772.1.
AF043448 mRNA. Translation: AAC39773.1.
AF043449 mRNA. Translation: AAC39774.1.
PIRiS71754.

3D structure databases

ProteinModelPortaliO46598.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAVR1_CHLAE
AccessioniPrimary (citable) accession number: O46598
Secondary accession number(s): O18984
, O46597, Q7JJ47, Q7JJ48, Q95144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 6, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.