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O46598

- HAVR1_CHLAE

UniProt

O46598 - HAVR1_CHLAE

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Protein
Hepatitis A virus cellular receptor 1
Gene
HAVCR1, TIM1, TIMD1
Organism
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 By similarity. In case of simian hepatitis A virus (SHAV) infection, functions as a cell-surface receptor for the virus.1 Publication

GO - Molecular functioni

  1. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1
Short name:
HAVcr-1
Alternative name(s):
T-cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
T-cell immunoglobulin mucin receptor 1
Short name:
TIM-1
T-cell membrane protein 1
Gene namesi
Name:HAVCR1
Synonyms:TIM1, TIMD1
OrganismiChlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Taxonomic identifieri9534 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 397373Extracellular Reviewed prediction
Add
BLAST
Transmembranei398 – 41821Helical; Reviewed prediction
Add
BLAST
Topological domaini419 – 47860Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 478454Hepatitis A virus cellular receptor 1
PRO_5000146882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 110 By similarity
Disulfide bondi51 ↔ 62 By similarity
Disulfide bondi57 ↔ 109 By similarity
Glycosylationi70 – 701N-linked (GlcNAc...) Inferred
Glycosylationi87 – 871N-linked (GlcNAc...) Inferred
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Binds to immunoglobulin A (IgA). Associtation with IgA enhances hepatitis A virus-receptor interaction By similarity.

Structurei

3D structure databases

ProteinModelPortaliO46598.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 126102Ig-like V-type
Add
BLAST
Repeati148 – 15581
Repeati156 – 16162
Repeati162 – 16763
Repeati168 – 17364
Repeati174 – 17965
Repeati180 – 18566
Repeati186 – 19167
Repeati192 – 19768
Repeati198 – 20149
Repeati202 – 207610
Repeati208 – 211411
Repeati212 – 217612
Repeati218 – 221413
Repeati222 – 227614
Repeati228 – 233615
Repeati234 – 239616
Repeati240 – 245617
Repeati246 – 251618
Repeati252 – 257619
Repeati258 – 263620
Repeati264 – 268521
Repeati269 – 273522
Repeati274 – 279623
Repeati280 – 285624
Repeati286 – 291625
Repeati292 – 297626
Repeati298 – 303627
Repeati304 – 309628

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 30916228 X 6 AA approximate tandem repeats of L-P-[MT]-T-[MT]-T
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 369235Thr-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform long (identifier: O46598-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADPIMHLQV VILSLILHLA DSVADSVNVD GVAGLSITLP CRYNGAITSM    50
CWNRGTCSVF SCPDGIVWTN GTHVTYRKET RYKLLGNLSR RDVSLTIANT 100
AVSDSGIYCC RVKHSGWFND MKITISLKIG PPRVTIPIVR TVRTSTTVPT 150
TTTTTLPTTT TLPTTTTLPT TMTLPTTTTL PMTTTLPTTT TVPMTTTLPT 200
TLPTTTTLPT TLPTTTTLPT TLPTTTTLPT TMTLPMTTTL PTTTTLPTTT 250
TLPTTTTLPT TTTLPTTTLP TMTLPTTTTL PTTMTLPMTT TLPTTTTLPT 300
TTTLPTTTMV STFVPPTPLP MQDHEPVATS PSSAQPAETH PVTLLGATRT 350
QPTSSPLYSY TTDGSDTVTE SSDGLWNNNQ TQLSPEHSPQ MVNTTEGIYA 400
GVCISVLVLL AVLGVVIAKK YFFKKEIQQL SVSFSNHQFK TLQNAVKKEV 450
HAEDNIYIEN NLYAMNQDPV VLFESLRP 478
Length:478
Mass (Da):51,490
Last modified:November 13, 2007 - v2
Checksum:iA2794438E8BAC379
GO
Isoform short (identifier: O46598-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.

Show »
Length:473
Mass (Da):50,963
Checksum:i55FD3D33C874BC0A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 55Missing in isoform short.
VSP_029086

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221S → F in BAA21556. 1 Publication
Sequence conflicti53 – 531N → H in AAC39771. 1 Publication
Sequence conflicti53 – 531N → H in AAC39772. 1 Publication
Sequence conflicti53 – 531N → H in AAC39773. 1 Publication
Sequence conflicti136 – 1361I → T in CAA66906. 1 Publication
Sequence conflicti153 – 1542Missing in CAA66906. 1 Publication
Sequence conflicti172 – 1721M → T in CAA66906. 1 Publication
Sequence conflicti172 – 1721M → T in BAA21556. 1 Publication
Sequence conflicti176 – 1761T → M in CAA66906. 1 Publication
Sequence conflicti194 – 1941M → T in BAA21556. 1 Publication
Sequence conflicti194 – 1941M → T in CAA66906. 1 Publication
Sequence conflicti196 – 20914Missing in CAA66906. 1 Publication
Add
BLAST
Sequence conflicti207 – 2071Missing in BAA21556. 1 Publication
Sequence conflicti212 – 2154Missing in AAC39771. 1 Publication
Sequence conflicti212 – 2154Missing in AAC39772. 1 Publication
Sequence conflicti224 – 2241T → M in CAA66906. 1 Publication
Sequence conflicti232 – 2321M → R in CAA66906. 1 Publication
Sequence conflicti236 – 2361M → T in CAA66906. 1 Publication
Sequence conflicti240 – 2401L → I in AAC39771. 1 Publication
Sequence conflicti240 – 2401L → I in AAC39772. 1 Publication
Sequence conflicti243 – 2431T → M in BAA21556. 1 Publication
Sequence conflicti244 – 2441T → M in CAA66906. 1 Publication
Sequence conflicti248 – 2481T → M in CAA66906. 1 Publication
Sequence conflicti257 – 26812Missing in BAA21556. 1 Publication
Add
BLAST
Sequence conflicti283 – 2908TMTLPMTT → MM in CAA66906. 1 Publication
Sequence conflicti323 – 3231D → N in CAA66906. 1 Publication
Sequence conflicti323 – 3231D → N in BAA21556. 1 Publication
Sequence conflicti334 – 3341A → P in CAA66906. 1 Publication
Sequence conflicti334 – 3341A → P in BAA21556. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98252 mRNA. Translation: CAA66906.1.
D88585 mRNA. Translation: BAA21556.1.
AF043446 mRNA. Translation: AAC39771.1.
AF043447 mRNA. Translation: AAC39772.1.
AF043448 mRNA. Translation: AAC39773.1.
AF043449 mRNA. Translation: AAC39774.1.
PIRiS71754.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98252 mRNA. Translation: CAA66906.1 .
D88585 mRNA. Translation: BAA21556.1 .
AF043446 mRNA. Translation: AAC39771.1 .
AF043447 mRNA. Translation: AAC39772.1 .
AF043448 mRNA. Translation: AAC39773.1 .
AF043449 mRNA. Translation: AAC39774.1 .
PIRi S71754.

3D structure databases

ProteinModelPortali O46598.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus."
    Kaplan G.G., Totsuka A., Thompson P., Akatsuka T., Moritsugu Y., Feinstone S.M.
    EMBO J. 15:4282-4296(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), FUNCTION AS A HAV RECEPTOR.
  2. "Molecular cloning of the hepatitis A virus receptor from a simian cell line."
    Ashida M., Hamada C.
    J. Gen. Virol. 78:1565-1569(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  3. "Polymorphisms of the hepatitis A virus cellular receptor 1 in African green monkey kidney cells result in antigenic variants that do not react with protective monoclonal antibody 190/4."
    Feigelstock D., Thompson P., Mattoo P., Kaplan G.G.
    J. Virol. 72:6218-6222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
  4. "The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4."
    Thompson P., Lu J., Kaplan G.G.
    J. Virol. 72:3751-3761(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-70 AND ASN-87.

Entry informationi

Entry nameiHAVR1_CHLAE
AccessioniPrimary (citable) accession number: O46598
Secondary accession number(s): O18984
, O46597, Q7JJ47, Q7JJ48, Q95144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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