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O46598

- HAVR1_CHLAE

UniProt

O46598 - HAVR1_CHLAE

Protein

Hepatitis A virus cellular receptor 1

Gene

HAVCR1

Organism
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 By similarity. In case of simian hepatitis A virus (SHAV) infection, functions as a cell-surface receptor for the virus.By similarity1 Publication

    GO - Molecular functioni

    1. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Receptor

    Keywords - Biological processi

    Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatitis A virus cellular receptor 1
    Short name:
    HAVcr-1
    Alternative name(s):
    T-cell immunoglobulin and mucin domain-containing protein 1
    Short name:
    TIMD-1
    T-cell immunoglobulin mucin receptor 1
    Short name:
    TIM-1
    T-cell membrane protein 1
    Gene namesi
    Name:HAVCR1
    Synonyms:TIM1, TIMD1
    OrganismiChlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
    Taxonomic identifieri9534 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 478454Hepatitis A virus cellular receptor 1PRO_5000146882Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 110PROSITE-ProRule annotation
    Disulfide bondi51 ↔ 62PROSITE-ProRule annotation
    Disulfide bondi57 ↔ 109PROSITE-ProRule annotation
    Glycosylationi70 – 701N-linked (GlcNAc...)1 Publication
    Glycosylationi87 – 871N-linked (GlcNAc...)1 Publication
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Binds to immunoglobulin A (IgA). Associtation with IgA enhances hepatitis A virus-receptor interaction By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO46598.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 397373ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini419 – 47860CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 126102Ig-like V-typeAdd
    BLAST
    Repeati148 – 15581
    Repeati156 – 16162
    Repeati162 – 16763
    Repeati168 – 17364
    Repeati174 – 17965
    Repeati180 – 18566
    Repeati186 – 19167
    Repeati192 – 19768
    Repeati198 – 20149
    Repeati202 – 207610
    Repeati208 – 211411
    Repeati212 – 217612
    Repeati218 – 221413
    Repeati222 – 227614
    Repeati228 – 233615
    Repeati234 – 239616
    Repeati240 – 245617
    Repeati246 – 251618
    Repeati252 – 257619
    Repeati258 – 263620
    Repeati264 – 268521
    Repeati269 – 273522
    Repeati274 – 279623
    Repeati280 – 285624
    Repeati286 – 291625
    Repeati292 – 297626
    Repeati298 – 303627
    Repeati304 – 309628

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni148 – 30916228 X 6 AA approximate tandem repeats of L-P-[MT]-T-[MT]-TAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi135 – 369235Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. TIM family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform long (identifier: O46598-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADPIMHLQV VILSLILHLA DSVADSVNVD GVAGLSITLP CRYNGAITSM    50
    CWNRGTCSVF SCPDGIVWTN GTHVTYRKET RYKLLGNLSR RDVSLTIANT 100
    AVSDSGIYCC RVKHSGWFND MKITISLKIG PPRVTIPIVR TVRTSTTVPT 150
    TTTTTLPTTT TLPTTTTLPT TMTLPTTTTL PMTTTLPTTT TVPMTTTLPT 200
    TLPTTTTLPT TLPTTTTLPT TLPTTTTLPT TMTLPMTTTL PTTTTLPTTT 250
    TLPTTTTLPT TTTLPTTTLP TMTLPTTTTL PTTMTLPMTT TLPTTTTLPT 300
    TTTLPTTTMV STFVPPTPLP MQDHEPVATS PSSAQPAETH PVTLLGATRT 350
    QPTSSPLYSY TTDGSDTVTE SSDGLWNNNQ TQLSPEHSPQ MVNTTEGIYA 400
    GVCISVLVLL AVLGVVIAKK YFFKKEIQQL SVSFSNHQFK TLQNAVKKEV 450
    HAEDNIYIEN NLYAMNQDPV VLFESLRP 478
    Length:478
    Mass (Da):51,490
    Last modified:November 13, 2007 - v2
    Checksum:iA2794438E8BAC379
    GO
    Isoform short (identifier: O46598-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-5: Missing.

    Show »
    Length:473
    Mass (Da):50,963
    Checksum:i55FD3D33C874BC0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221S → F in BAA21556. (PubMed:9225030)Curated
    Sequence conflicti53 – 531N → H in AAC39771. (PubMed:9621093)Curated
    Sequence conflicti53 – 531N → H in AAC39772. (PubMed:9621093)Curated
    Sequence conflicti53 – 531N → H in AAC39773. (PubMed:9621093)Curated
    Sequence conflicti136 – 1361I → T in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti153 – 1542Missing in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti172 – 1721M → T in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti172 – 1721M → T in BAA21556. (PubMed:9225030)Curated
    Sequence conflicti176 – 1761T → M in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti194 – 1941M → T in BAA21556. (PubMed:9225030)Curated
    Sequence conflicti194 – 1941M → T in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti196 – 20914Missing in CAA66906. (PubMed:8861957)CuratedAdd
    BLAST
    Sequence conflicti207 – 2071Missing in BAA21556. (PubMed:9225030)Curated
    Sequence conflicti212 – 2154Missing in AAC39771. (PubMed:9621093)Curated
    Sequence conflicti212 – 2154Missing in AAC39772. (PubMed:9621093)Curated
    Sequence conflicti224 – 2241T → M in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti232 – 2321M → R in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti236 – 2361M → T in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti240 – 2401L → I in AAC39771. (PubMed:9621093)Curated
    Sequence conflicti240 – 2401L → I in AAC39772. (PubMed:9621093)Curated
    Sequence conflicti243 – 2431T → M in BAA21556. (PubMed:9225030)Curated
    Sequence conflicti244 – 2441T → M in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti248 – 2481T → M in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti257 – 26812Missing in BAA21556. (PubMed:9225030)CuratedAdd
    BLAST
    Sequence conflicti283 – 2908TMTLPMTT → MM in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti323 – 3231D → N in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti323 – 3231D → N in BAA21556. (PubMed:9225030)Curated
    Sequence conflicti334 – 3341A → P in CAA66906. (PubMed:8861957)Curated
    Sequence conflicti334 – 3341A → P in BAA21556. (PubMed:9225030)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 55Missing in isoform short. 3 PublicationsVSP_029086

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98252 mRNA. Translation: CAA66906.1.
    D88585 mRNA. Translation: BAA21556.1.
    AF043446 mRNA. Translation: AAC39771.1.
    AF043447 mRNA. Translation: AAC39772.1.
    AF043448 mRNA. Translation: AAC39773.1.
    AF043449 mRNA. Translation: AAC39774.1.
    PIRiS71754.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98252 mRNA. Translation: CAA66906.1 .
    D88585 mRNA. Translation: BAA21556.1 .
    AF043446 mRNA. Translation: AAC39771.1 .
    AF043447 mRNA. Translation: AAC39772.1 .
    AF043448 mRNA. Translation: AAC39773.1 .
    AF043449 mRNA. Translation: AAC39774.1 .
    PIRi S71754.

    3D structure databases

    ProteinModelPortali O46598.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus."
      Kaplan G.G., Totsuka A., Thompson P., Akatsuka T., Moritsugu Y., Feinstone S.M.
      EMBO J. 15:4282-4296(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), FUNCTION AS A HAV RECEPTOR.
    2. "Molecular cloning of the hepatitis A virus receptor from a simian cell line."
      Ashida M., Hamada C.
      J. Gen. Virol. 78:1565-1569(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    3. "Polymorphisms of the hepatitis A virus cellular receptor 1 in African green monkey kidney cells result in antigenic variants that do not react with protective monoclonal antibody 190/4."
      Feigelstock D., Thompson P., Mattoo P., Kaplan G.G.
      J. Virol. 72:6218-6222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    4. "The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4."
      Thompson P., Lu J., Kaplan G.G.
      J. Virol. 72:3751-3761(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-70 AND ASN-87.

    Entry informationi

    Entry nameiHAVR1_CHLAE
    AccessioniPrimary (citable) accession number: O46598
    Secondary accession number(s): O18984
    , O46597, Q7JJ47, Q7JJ48, Q95144
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3