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O46598 (HAVR1_CHLAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatitis A virus cellular receptor 1

Short name=HAVcr-1
Alternative name(s):
T-cell immunoglobulin and mucin domain-containing protein 1
Short name=TIMD-1
T-cell immunoglobulin mucin receptor 1
Short name=TIM-1
T-cell membrane protein 1
Gene names
Name:HAVCR1
Synonyms:TIM1, TIMD1
OrganismChlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Taxonomic identifier9534 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 By similarity. In case of simian hepatitis A virus (SHAV) infection, functions as a cell-surface receptor for the virus. Ref.1

Subunit structure

Binds to immunoglobulin A (IgA). Associtation with IgA enhances hepatitis A virus-receptor interaction By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Sequence similarities

Belongs to the immunoglobulin superfamily. TIM family.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionHost cell receptor for virus entry
Receptor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionvirus receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform long (identifier: O46598-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform short (identifier: O46598-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 478454Hepatitis A virus cellular receptor 1
PRO_5000146882

Regions

Topological domain25 – 397373Extracellular Potential
Transmembrane398 – 41821Helical; Potential
Topological domain419 – 47860Cytoplasmic Potential
Domain25 – 126102Ig-like V-type
Repeat148 – 15581
Repeat156 – 16162
Repeat162 – 16763
Repeat168 – 17364
Repeat174 – 17965
Repeat180 – 18566
Repeat186 – 19167
Repeat192 – 19768
Repeat198 – 20149
Repeat202 – 207610
Repeat208 – 211411
Repeat212 – 217612
Repeat218 – 221413
Repeat222 – 227614
Repeat228 – 233615
Repeat234 – 239616
Repeat240 – 245617
Repeat246 – 251618
Repeat252 – 257619
Repeat258 – 263620
Repeat264 – 268521
Repeat269 – 273522
Repeat274 – 279623
Repeat280 – 285624
Repeat286 – 291625
Repeat292 – 297626
Repeat298 – 303627
Repeat304 – 309628
Region148 – 30916228 X 6 AA approximate tandem repeats of L-P-[MT]-T-[MT]-T
Compositional bias135 – 369235Thr-rich

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Probable
Glycosylation871N-linked (GlcNAc...) Probable
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation3931N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 110 By similarity
Disulfide bond51 ↔ 62 By similarity
Disulfide bond57 ↔ 109 By similarity

Natural variations

Alternative sequence1 – 55Missing in isoform short.
VSP_029086

Experimental info

Sequence conflict221S → F in BAA21556. Ref.2
Sequence conflict531N → H in AAC39771. Ref.3
Sequence conflict531N → H in AAC39772. Ref.3
Sequence conflict531N → H in AAC39773. Ref.3
Sequence conflict1361I → T in CAA66906. Ref.1
Sequence conflict153 – 1542Missing in CAA66906. Ref.1
Sequence conflict1721M → T in CAA66906. Ref.1
Sequence conflict1721M → T in BAA21556. Ref.2
Sequence conflict1761T → M in CAA66906. Ref.1
Sequence conflict1941M → T in BAA21556. Ref.2
Sequence conflict1941M → T in CAA66906. Ref.1
Sequence conflict196 – 20914Missing in CAA66906. Ref.1
Sequence conflict2071Missing in BAA21556. Ref.2
Sequence conflict212 – 2154Missing in AAC39771. Ref.3
Sequence conflict212 – 2154Missing in AAC39772. Ref.3
Sequence conflict2241T → M in CAA66906. Ref.1
Sequence conflict2321M → R in CAA66906. Ref.1
Sequence conflict2361M → T in CAA66906. Ref.1
Sequence conflict2401L → I in AAC39771. Ref.3
Sequence conflict2401L → I in AAC39772. Ref.3
Sequence conflict2431T → M in BAA21556. Ref.2
Sequence conflict2441T → M in CAA66906. Ref.1
Sequence conflict2481T → M in CAA66906. Ref.1
Sequence conflict257 – 26812Missing in BAA21556. Ref.2
Sequence conflict283 – 2908TMTLPMTT → MM in CAA66906. Ref.1
Sequence conflict3231D → N in CAA66906. Ref.1
Sequence conflict3231D → N in BAA21556. Ref.2
Sequence conflict3341A → P in CAA66906. Ref.1
Sequence conflict3341A → P in BAA21556. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform long [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: A2794438E8BAC379

FASTA47851,490
        10         20         30         40         50         60 
MADPIMHLQV VILSLILHLA DSVADSVNVD GVAGLSITLP CRYNGAITSM CWNRGTCSVF 

        70         80         90        100        110        120 
SCPDGIVWTN GTHVTYRKET RYKLLGNLSR RDVSLTIANT AVSDSGIYCC RVKHSGWFND 

       130        140        150        160        170        180 
MKITISLKIG PPRVTIPIVR TVRTSTTVPT TTTTTLPTTT TLPTTTTLPT TMTLPTTTTL 

       190        200        210        220        230        240 
PMTTTLPTTT TVPMTTTLPT TLPTTTTLPT TLPTTTTLPT TLPTTTTLPT TMTLPMTTTL 

       250        260        270        280        290        300 
PTTTTLPTTT TLPTTTTLPT TTTLPTTTLP TMTLPTTTTL PTTMTLPMTT TLPTTTTLPT 

       310        320        330        340        350        360 
TTTLPTTTMV STFVPPTPLP MQDHEPVATS PSSAQPAETH PVTLLGATRT QPTSSPLYSY 

       370        380        390        400        410        420 
TTDGSDTVTE SSDGLWNNNQ TQLSPEHSPQ MVNTTEGIYA GVCISVLVLL AVLGVVIAKK 

       430        440        450        460        470 
YFFKKEIQQL SVSFSNHQFK TLQNAVKKEV HAEDNIYIEN NLYAMNQDPV VLFESLRP 

« Hide

Isoform short [UniParc].

Checksum: 55FD3D33C874BC0A
Show »

FASTA47350,963

References

[1]"Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus."
Kaplan G.G., Totsuka A., Thompson P., Akatsuka T., Moritsugu Y., Feinstone S.M.
EMBO J. 15:4282-4296(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), FUNCTION AS A HAV RECEPTOR.
[2]"Molecular cloning of the hepatitis A virus receptor from a simian cell line."
Ashida M., Hamada C.
J. Gen. Virol. 78:1565-1569(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
[3]"Polymorphisms of the hepatitis A virus cellular receptor 1 in African green monkey kidney cells result in antigenic variants that do not react with protective monoclonal antibody 190/4."
Feigelstock D., Thompson P., Mattoo P., Kaplan G.G.
J. Virol. 72:6218-6222(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
[4]"The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4."
Thompson P., Lu J., Kaplan G.G.
J. Virol. 72:3751-3761(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-70 AND ASN-87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X98252 mRNA. Translation: CAA66906.1.
D88585 mRNA. Translation: BAA21556.1.
AF043446 mRNA. Translation: AAC39771.1.
AF043447 mRNA. Translation: AAC39772.1.
AF043448 mRNA. Translation: AAC39773.1.
AF043449 mRNA. Translation: AAC39774.1.
PIRS71754.

3D structure databases

ProteinModelPortalO46598.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHAVR1_CHLAE
AccessionPrimary (citable) accession number: O46598
Secondary accession number(s): O18984 expand/collapse secondary AC list , O46597, Q7JJ47, Q7JJ48, Q95144
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families