Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O46598

- HAVR1_CHLAE

UniProt

O46598 - HAVR1_CHLAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hepatitis A virus cellular receptor 1

Gene

HAVCR1

Organism
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of simian hepatitis A virus (SHAV) infection, functions as a cell-surface receptor for the virus.By similarity1 Publication

GO - Molecular functioni

  1. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1
Short name:
HAVcr-1
Alternative name(s):
T-cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
T-cell immunoglobulin mucin receptor 1
Short name:
TIM-1
T-cell membrane protein 1
Gene namesi
Name:HAVCR1
Synonyms:TIM1, TIMD1
OrganismiChlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Taxonomic identifieri9534 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 397373ExtracellularSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Topological domaini419 – 47860CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 478454Hepatitis A virus cellular receptor 1PRO_5000146882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 110PROSITE-ProRule annotation
Disulfide bondi51 ↔ 62PROSITE-ProRule annotation
Disulfide bondi57 ↔ 109PROSITE-ProRule annotation
Glycosylationi70 – 701N-linked (GlcNAc...)1 Publication
Glycosylationi87 – 871N-linked (GlcNAc...)1 Publication
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Binds to immunoglobulin A (IgA). Associtation with IgA enhances hepatitis A virus-receptor interaction (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO46598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 126102Ig-like V-typeAdd
BLAST
Repeati148 – 15581
Repeati156 – 16162
Repeati162 – 16763
Repeati168 – 17364
Repeati174 – 17965
Repeati180 – 18566
Repeati186 – 19167
Repeati192 – 19768
Repeati198 – 20149
Repeati202 – 207610
Repeati208 – 211411
Repeati212 – 217612
Repeati218 – 221413
Repeati222 – 227614
Repeati228 – 233615
Repeati234 – 239616
Repeati240 – 245617
Repeati246 – 251618
Repeati252 – 257619
Repeati258 – 263620
Repeati264 – 268521
Repeati269 – 273522
Repeati274 – 279623
Repeati280 – 285624
Repeati286 – 291625
Repeati292 – 297626
Repeati298 – 303627
Repeati304 – 309628

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 30916228 X 6 AA approximate tandem repeats of L-P-[MT]-T-[MT]-TAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 369235Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform long (identifier: O46598-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADPIMHLQV VILSLILHLA DSVADSVNVD GVAGLSITLP CRYNGAITSM
60 70 80 90 100
CWNRGTCSVF SCPDGIVWTN GTHVTYRKET RYKLLGNLSR RDVSLTIANT
110 120 130 140 150
AVSDSGIYCC RVKHSGWFND MKITISLKIG PPRVTIPIVR TVRTSTTVPT
160 170 180 190 200
TTTTTLPTTT TLPTTTTLPT TMTLPTTTTL PMTTTLPTTT TVPMTTTLPT
210 220 230 240 250
TLPTTTTLPT TLPTTTTLPT TLPTTTTLPT TMTLPMTTTL PTTTTLPTTT
260 270 280 290 300
TLPTTTTLPT TTTLPTTTLP TMTLPTTTTL PTTMTLPMTT TLPTTTTLPT
310 320 330 340 350
TTTLPTTTMV STFVPPTPLP MQDHEPVATS PSSAQPAETH PVTLLGATRT
360 370 380 390 400
QPTSSPLYSY TTDGSDTVTE SSDGLWNNNQ TQLSPEHSPQ MVNTTEGIYA
410 420 430 440 450
GVCISVLVLL AVLGVVIAKK YFFKKEIQQL SVSFSNHQFK TLQNAVKKEV
460 470
HAEDNIYIEN NLYAMNQDPV VLFESLRP
Length:478
Mass (Da):51,490
Last modified:November 13, 2007 - v2
Checksum:iA2794438E8BAC379
GO
Isoform short (identifier: O46598-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.

Show »
Length:473
Mass (Da):50,963
Checksum:i55FD3D33C874BC0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221S → F in BAA21556. (PubMed:9225030)Curated
Sequence conflicti53 – 531N → H in AAC39771. (PubMed:9621093)Curated
Sequence conflicti53 – 531N → H in AAC39772. (PubMed:9621093)Curated
Sequence conflicti53 – 531N → H in AAC39773. (PubMed:9621093)Curated
Sequence conflicti136 – 1361I → T in CAA66906. (PubMed:8861957)Curated
Sequence conflicti153 – 1542Missing in CAA66906. (PubMed:8861957)Curated
Sequence conflicti172 – 1721M → T in CAA66906. (PubMed:8861957)Curated
Sequence conflicti172 – 1721M → T in BAA21556. (PubMed:9225030)Curated
Sequence conflicti176 – 1761T → M in CAA66906. (PubMed:8861957)Curated
Sequence conflicti194 – 1941M → T in BAA21556. (PubMed:9225030)Curated
Sequence conflicti194 – 1941M → T in CAA66906. (PubMed:8861957)Curated
Sequence conflicti196 – 20914Missing in CAA66906. (PubMed:8861957)CuratedAdd
BLAST
Sequence conflicti207 – 2071Missing in BAA21556. (PubMed:9225030)Curated
Sequence conflicti212 – 2154Missing in AAC39771. (PubMed:9621093)Curated
Sequence conflicti212 – 2154Missing in AAC39772. (PubMed:9621093)Curated
Sequence conflicti224 – 2241T → M in CAA66906. (PubMed:8861957)Curated
Sequence conflicti232 – 2321M → R in CAA66906. (PubMed:8861957)Curated
Sequence conflicti236 – 2361M → T in CAA66906. (PubMed:8861957)Curated
Sequence conflicti240 – 2401L → I in AAC39771. (PubMed:9621093)Curated
Sequence conflicti240 – 2401L → I in AAC39772. (PubMed:9621093)Curated
Sequence conflicti243 – 2431T → M in BAA21556. (PubMed:9225030)Curated
Sequence conflicti244 – 2441T → M in CAA66906. (PubMed:8861957)Curated
Sequence conflicti248 – 2481T → M in CAA66906. (PubMed:8861957)Curated
Sequence conflicti257 – 26812Missing in BAA21556. (PubMed:9225030)CuratedAdd
BLAST
Sequence conflicti283 – 2908TMTLPMTT → MM in CAA66906. (PubMed:8861957)Curated
Sequence conflicti323 – 3231D → N in CAA66906. (PubMed:8861957)Curated
Sequence conflicti323 – 3231D → N in BAA21556. (PubMed:9225030)Curated
Sequence conflicti334 – 3341A → P in CAA66906. (PubMed:8861957)Curated
Sequence conflicti334 – 3341A → P in BAA21556. (PubMed:9225030)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 55Missing in isoform short. 3 PublicationsVSP_029086

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98252 mRNA. Translation: CAA66906.1.
D88585 mRNA. Translation: BAA21556.1.
AF043446 mRNA. Translation: AAC39771.1.
AF043447 mRNA. Translation: AAC39772.1.
AF043448 mRNA. Translation: AAC39773.1.
AF043449 mRNA. Translation: AAC39774.1.
PIRiS71754.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98252 mRNA. Translation: CAA66906.1 .
D88585 mRNA. Translation: BAA21556.1 .
AF043446 mRNA. Translation: AAC39771.1 .
AF043447 mRNA. Translation: AAC39772.1 .
AF043448 mRNA. Translation: AAC39773.1 .
AF043449 mRNA. Translation: AAC39774.1 .
PIRi S71754.

3D structure databases

ProteinModelPortali O46598.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus."
    Kaplan G.G., Totsuka A., Thompson P., Akatsuka T., Moritsugu Y., Feinstone S.M.
    EMBO J. 15:4282-4296(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), FUNCTION AS A HAV RECEPTOR.
  2. "Molecular cloning of the hepatitis A virus receptor from a simian cell line."
    Ashida M., Hamada C.
    J. Gen. Virol. 78:1565-1569(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  3. "Polymorphisms of the hepatitis A virus cellular receptor 1 in African green monkey kidney cells result in antigenic variants that do not react with protective monoclonal antibody 190/4."
    Feigelstock D., Thompson P., Mattoo P., Kaplan G.G.
    J. Virol. 72:6218-6222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
  4. "The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4."
    Thompson P., Lu J., Kaplan G.G.
    J. Virol. 72:3751-3761(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-70 AND ASN-87.

Entry informationi

Entry nameiHAVR1_CHLAE
AccessioniPrimary (citable) accession number: O46598
Secondary accession number(s): O18984
, O46597, Q7JJ47, Q7JJ48, Q95144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 1, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3