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Protein

V-type proton ATPase subunit H

Gene

ATP6V1H

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit H
Short name:
V-ATPase subunit H
Alternative name(s):
V-ATPase 50/57 kDa subunits
Vacuolar proton pump subunit H
Vacuolar proton pump subunit SFD
Gene namesi
Name:ATP6V1H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483V-type proton ATPase subunit HPRO_0000124192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei483 – 4831PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO46563.
PRIDEiO46563.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with AP2M1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004480.

Structurei

3D structure databases

ProteinModelPortaliO46563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase H subunit family.Curated

Phylogenomic databases

eggNOGiKOG2759. Eukaryota.
COG5231. LUCA.
HOGENOMiHOG000007240.
HOVERGENiHBG000459.
InParanoidiO46563.
KOiK02144.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
1.25.40.150. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004908. ATPase_V1-cplx_hsu.
IPR011987. ATPase_V1-cplx_hsu_C.
[Graphical view]
PANTHERiPTHR10698. PTHR10698. 1 hit.
PfamiPF11698. V-ATPase_H_C. 1 hit.
[Graphical view]
PIRSFiPIRSF032184. ATPase_V1_H. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: O46563-1) [UniParc]FASTAAdd to basket
Also known as: 57 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISSEDCEFI
60 70 80 90 100
QRFEMKRSPE EKQEMLQTEG SQCAKTFINL MTHISKEQTV QYILTLVDDT
110 120 130 140 150
LQENHQRVSI FFDYAKRSKN TAWSYFLPML NRQDLFTVHM AARIIAKLAA
160 170 180 190 200
WGKELMEGSD LNYYFNWIKT QLSSQKLRGS GVTAETGTVS SSDSSQYVQC
210 220 230 240 250
VAGCLQLMLR VNEYRFAWVE ADGVNCIMGV LSNKCGFQLQ YQMIFSVWLL
260 270 280 290 300
AFSPQMCEHL RRYNIIPVLS DILQESVKEK VTRIILAAFR NFLEKSVERE
310 320 330 340 350
TRQEYALAMI QCKVLKQLEN LEQQKYDDED ISEDIKFLLE KLGESVQDLS
360 370 380 390 400
SFDEYSSELK SGRLEWSPVH KSEKFWRENA VRLNEKNYEL LKILTKLLEV
410 420 430 440 450
SDDPQVLAVA AHDVGEYVRH YPRGKRVIEQ LGGKQLVMNH MHHEDQQVRY
460 470 480
NALLAVQKLM VHNWEYLGKQ LQSEQPQTAA ARS
Length:483
Mass (Da):55,852
Last modified:July 25, 2006 - v2
Checksum:i42C153026E7B949C
GO
Isoform Beta (identifier: O46563-2) [UniParc]FASTAAdd to basket
Also known as: 50 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     176-193: Missing.

Show »
Length:465
Mass (Da):54,118
Checksum:iEF7DCEAFE8C5FECD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731C → R in AAC02987 (PubMed:9488725).Curated
Sequence conflicti73 – 731C → R in AAC02986 (PubMed:9488725).Curated
Sequence conflicti141 – 1411A → T in AAC02987 (PubMed:9488725).Curated
Sequence conflicti141 – 1411A → T in AAC02986 (PubMed:9488725).Curated
Sequence conflicti380 – 3812AV → PA in AAC02987 (PubMed:9488725).Curated
Sequence conflicti380 – 3812AV → PA in AAC02986 (PubMed:9488725).Curated
Sequence conflicti444 – 4441E → G in AAI03433 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 19318Missing in isoform Beta. 2 PublicationsVSP_000442Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041338 mRNA. Translation: AAC02987.1.
AF041337 mRNA. Translation: AAC02986.1.
BC103432 mRNA. Translation: AAI03433.1.
RefSeqiNP_777129.2. NM_174704.3.
UniGeneiBt.49330.

Genome annotation databases

GeneIDi282657.
KEGGibta:282657.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041338 mRNA. Translation: AAC02987.1.
AF041337 mRNA. Translation: AAC02986.1.
BC103432 mRNA. Translation: AAI03433.1.
RefSeqiNP_777129.2. NM_174704.3.
UniGeneiBt.49330.

3D structure databases

ProteinModelPortaliO46563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004480.

Proteomic databases

PaxDbiO46563.
PRIDEiO46563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282657.
KEGGibta:282657.

Organism-specific databases

CTDi51606.

Phylogenomic databases

eggNOGiKOG2759. Eukaryota.
COG5231. LUCA.
HOGENOMiHOG000007240.
HOVERGENiHBG000459.
InParanoidiO46563.
KOiK02144.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
1.25.40.150. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004908. ATPase_V1-cplx_hsu.
IPR011987. ATPase_V1-cplx_hsu_C.
[Graphical view]
PANTHERiPTHR10698. PTHR10698. 1 hit.
PfamiPF11698. V-ATPase_H_C. 1 hit.
[Graphical view]
PIRSFiPIRSF032184. ATPase_V1_H. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATH_BOVIN
AccessioniPrimary (citable) accession number: O46563
Secondary accession number(s): O46562, Q3ZBD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 25, 2006
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.