Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O46559

- LIPC_RABIT

UniProt

O46559 - LIPC_RABIT

Protein

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin By similarity.By similarity

    Catalytic activityi

    Triacylglycerol + H2O = diacylglycerol + a carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei168 – 1681NucleophileBy similarity
    Active sitei194 – 1941Charge relay systemPROSITE-ProRule annotation
    Active sitei279 – 2791Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. triglyceride lipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatic triacylglycerol lipase (EC:3.1.1.3)
    Short name:
    HL
    Short name:
    Hepatic lipase
    Alternative name(s):
    Lipase member C
    Gene namesi
    Name:LIPC
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. high-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    HDL, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 499477Hepatic triacylglycerol lipasePRO_0000233341Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000001411.

    Structurei

    3D structure databases

    ProteinModelPortaliO46559.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini352 – 486135PLATPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni181 – 19313Heparin-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated
    Contains 1 PLAT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG81747.
    HOGENOMiHOG000038553.
    HOVERGENiHBG002259.

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR002333. Lipase_hep.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PTHR11610:SF2. PTHR11610:SF2. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSiPR00824. HEPLIPASE.
    PR00821. TAGLIPASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O46559-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSPLCVPIF LAVCILIQSS THGQSLRPEP FGRRARVTAT KKTLLETETR    50
    FLLFKDKANK GCQIRLHHAD TLQECGFNSS LPLVMIVHGW SVDGLLESWI 100
    WQMVAALKSQ PARPVNVGLV DWISLAHSHY AVAVRNARLV GQEVAALLQW 150
    LEESAPFSRS NVHLIGYSLG AHVAGFAGSY ISGKHKIGRI TGLDAAGPLF 200
    EGTSASDRLS PDDATFVDAI HTFTREHMGL SVGIKQPVGH YDFYPNGGSF 250
    QPGCHFLELY KHIAQHGLNA LSQTIKCAHE RSVHLFIDSL LHPSMQSTAY 300
    QCSDMDSFSQ GLCLGCTKGR CNTLGYHIRQ EPLSKGKRLF LVTQAQSPFR 350
    VYHYQFKIQF INQIEKPLEP TFTMSLLGTK EEMQKIPITL GEGITSNKTY 400
    SFLITLNLDI GELMVIKFKW ENSAVWANVW NTVQTIIPWG IKPRNSGLIL 450
    KTIRVKAGET QQRMTFCSEN MDDLQLHPTQ EKNFVRCEVN PKKLKLKIK 499
    Length:499
    Mass (Da):55,814
    Last modified:June 1, 1998 - v1
    Checksum:i4DA7D65EE815A0A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041202 mRNA. Translation: AAB96786.1.
    RefSeqiNP_001075501.1. NM_001082032.1.
    UniGeneiOcu.2193.

    Genome annotation databases

    GeneIDi100008678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041202 mRNA. Translation: AAB96786.1 .
    RefSeqi NP_001075501.1. NM_001082032.1.
    UniGenei Ocu.2193.

    3D structure databases

    ProteinModelPortali O46559.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000001411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100008678.

    Organism-specific databases

    CTDi 3990.

    Phylogenomic databases

    eggNOGi NOG81747.
    HOGENOMi HOG000038553.
    HOVERGENi HBG002259.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR002333. Lipase_hep.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    PTHR11610:SF2. PTHR11610:SF2. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSi PR00824. HEPLIPASE.
    PR00821. TAGLIPASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels."
      Warren R.J., Ebert D.L., Mitchell A., Barter P.J.
      J. Lipid Res. 32:1333-1339(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Warren R.J., Ebert D.L., Mitchell A., Barter P.J.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiLIPC_RABIT
    AccessioniPrimary (citable) accession number: O46559
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3