Reviewed, UniProtKB/Swiss-Prot O46559 (LIPC_RABIT)

Names and origin

Protein names

Recommended name:
    Hepatic triacylglycerol lipase
      Short name=Hepatic lipase
      Short name=HL
    EC=3.1.1.3
Alternative name(s):
    Lipase member C

Gene names

Name:

LIPC

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin By similarity.
Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	HDL Secreted
Domain	Signal
Ligand	Heparin-binding
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	heparin binding Inferred from electronic annotation. Source: UniProtKB-KW triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Chain	23 – 499	477	Hepatic triacylglycerol lipase		PRO_0000233341
Regions
	Domain	352 – 486	135	PLAT
	Region	181 – 193	13	Heparin-binding Potential
Sites
	Active site	168	1	Nucleophile By similarity
	Active site	194	1	Charge relay system By similarity
	Active site	279	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Glycosylation	397	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O46559-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 4DA7D65EE815A0A5	FASTA	499	55,814
	10 20 30 40 50 60 MGSPLCVPIF LAVCILIQSS THGQSLRPEP FGRRARVTAT KKTLLETETR FLLFKDKANK 70 80 90 100 110 120 GCQIRLHHAD TLQECGFNSS LPLVMIVHGW SVDGLLESWI WQMVAALKSQ PARPVNVGLV 130 140 150 160 170 180 DWISLAHSHY AVAVRNARLV GQEVAALLQW LEESAPFSRS NVHLIGYSLG AHVAGFAGSY 190 200 210 220 230 240 ISGKHKIGRI TGLDAAGPLF EGTSASDRLS PDDATFVDAI HTFTREHMGL SVGIKQPVGH 250 260 270 280 290 300 YDFYPNGGSF QPGCHFLELY KHIAQHGLNA LSQTIKCAHE RSVHLFIDSL LHPSMQSTAY 310 320 330 340 350 360 QCSDMDSFSQ GLCLGCTKGR CNTLGYHIRQ EPLSKGKRLF LVTQAQSPFR VYHYQFKIQF 370 380 390 400 410 420 INQIEKPLEP TFTMSLLGTK EEMQKIPITL GEGITSNKTY SFLITLNLDI GELMVIKFKW 430 440 450 460 470 480 ENSAVWANVW NTVQTIIPWG IKPRNSGLIL KTIRVKAGET QQRMTFCSEN MDDLQLHPTQ 490 EKNFVRCEVN PKKLKLKIK

References

[1]	"Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels." Warren R.J., Ebert D.L., Mitchell A., Barter P.J. J. Lipid Res. 32:1333-1339(1991) [PubMed: 1770315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Warren R.J., Ebert D.L., Mitchell A., Barter P.J. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF041202 mRNA. Translation: AAB96786.1.
RefSeq	NP_001075501.1.
UniGene	Ocu.2193
3D structure databases
SMR	O46559. Positions 45-472.
ModBase	Search...
Protein-protein interaction databases
STRING	O46559.
Genome annotation databases
GeneID	100008678.
Organism-specific databases
CTD	100008678.
Phylogenomic databases
eggNOG	maNOG15677.
HOVERGEN	O46559.
Enzyme and pathway databases
BRENDA	3.1.1.3. 255.
Family and domain databases
InterPro	IPR000734. Lipase. IPR002333. Lipase_hep. IPR008976. Lipase_LipOase. IPR013818. Lipase_N. IPR001024. LipOase_LH2. IPR016272. Lipoprotein_lipase_LIPH. [Graphical view]
PANTHER	PTHR11610. Lipase. 1 hit. PTHR11610:SF2. Lipase_hep. 1 hit.
Pfam	PF00151. Lipase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view]
PIRSF	PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTS	PR00824. HEPLIPASE. PR00821. TAGLIPASE.
SMART	SM00308. LH2. 1 hit. [Graphical view]
PROSITE	PS00120. LIPASE_SER. 1 hit. PS50095. PLAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIPC_RABIT

Accession

Primary (citable) accession number: O46559

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	June 1, 1998
Last modified:	January 19, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)