Reviewed,
UniProtKB/Swiss-Prot O46559 (LIPC_RABIT)
Last modified
January 19, 2010.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hepatic triacylglycerol lipase Short name=Hepatic lipase Short name=HL EC=3.1.1.3 Alternative name(s): Lipase member C | ||
| Gene names |
| ||
| Organism | Oryctolagus cuniculus (Rabbit) | ||
| Taxonomic identifier | 9986 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Protein attributes
| Sequence length | 499 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin By similarity. |
| Catalytic activity | Triacylglycerol + H2O = diacylglycerol + a carboxylate. |
| Subcellular location | Secreted By similarity. |
| Sequence similarities | Belongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation |
| Cellular component | HDL Secreted |
| Domain | Signal |
| Ligand | Heparin-binding |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | heparin binding Inferred from electronic annotation. Source: UniProtKB-KW triglyceride lipase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | By similarity | ||||||
| Chain | 23 – 499 | 477 | Hepatic triacylglycerol lipase | PRO_0000233341 | |||||
Regions | |||||||||
| Domain | 352 – 486 | 135 | PLAT | ||||||
| Region | 181 – 193 | 13 | Heparin-binding Potential | ||||||
Sites | |||||||||
| Active site | 168 | 1 | Nucleophile By similarity | ||||||
| Active site | 194 | 1 | Charge relay system By similarity | ||||||
| Active site | 279 | 1 | Charge relay system By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 78 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 397 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels." Warren R.J., Ebert D.L., Mitchell A., Barter P.J. J. Lipid Res. 32:1333-1339(1991) [PubMed: 1770315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Warren R.J., Ebert D.L., Mitchell A., Barter P.J. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF041202 mRNA. Translation: AAB96786.1. |
| RefSeq | NP_001075501.1. |
| UniGene | Ocu.2193 |
3D structure databases | |
| SMR | O46559. Positions 45-472. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O46559. |
Genome annotation databases | |
| GeneID | 100008678. |
Organism-specific databases | |
| CTD | 100008678. |
Phylogenomic databases | |
| eggNOG | maNOG15677. |
| HOVERGEN | O46559. |
Enzyme and pathway databases | |
| BRENDA | 3.1.1.3. 255. |
Family and domain databases | |
| InterPro | IPR000734. Lipase. IPR002333. Lipase_hep. IPR008976. Lipase_LipOase. IPR013818. Lipase_N. IPR001024. LipOase_LH2. IPR016272. Lipoprotein_lipase_LIPH. [Graphical view] |
| PANTHER | PTHR11610. Lipase. 1 hit. PTHR11610:SF2. Lipase_hep. 1 hit. |
| Pfam | PF00151. Lipase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view] |
| PIRSF | PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit. |
| PRINTS | PR00824. HEPLIPASE. PR00821. TAGLIPASE. |
| SMART | SM00308. LH2. 1 hit. [Graphical view] |
| PROSITE | PS00120. LIPASE_SER. 1 hit. PS50095. PLAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LIPC_RABIT | ||||||||
| Accession | Primary (citable) accession number: O46559 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


