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O46559 (LIPC_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatic triacylglycerol lipase

Short name=HL
Short name=Hepatic lipase
EC=3.1.1.3
Alternative name(s):
Lipase member C
Gene names
Name:LIPC
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin By similarity.

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Contains 1 PLAT domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentHDL
Secreted
   DomainSignal
   LigandHeparin-binding
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthigh-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

triglyceride lipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 499477Hepatic triacylglycerol lipase
PRO_0000233341

Regions

Domain352 – 486135PLAT
Region181 – 19313Heparin-binding Potential

Sites

Active site1681Nucleophile By similarity
Active site1941Charge relay system By similarity
Active site2791Charge relay system By similarity

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O46559 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 4DA7D65EE815A0A5

FASTA49955,814
        10         20         30         40         50         60 
MGSPLCVPIF LAVCILIQSS THGQSLRPEP FGRRARVTAT KKTLLETETR FLLFKDKANK 

        70         80         90        100        110        120 
GCQIRLHHAD TLQECGFNSS LPLVMIVHGW SVDGLLESWI WQMVAALKSQ PARPVNVGLV 

       130        140        150        160        170        180 
DWISLAHSHY AVAVRNARLV GQEVAALLQW LEESAPFSRS NVHLIGYSLG AHVAGFAGSY 

       190        200        210        220        230        240 
ISGKHKIGRI TGLDAAGPLF EGTSASDRLS PDDATFVDAI HTFTREHMGL SVGIKQPVGH 

       250        260        270        280        290        300 
YDFYPNGGSF QPGCHFLELY KHIAQHGLNA LSQTIKCAHE RSVHLFIDSL LHPSMQSTAY 

       310        320        330        340        350        360 
QCSDMDSFSQ GLCLGCTKGR CNTLGYHIRQ EPLSKGKRLF LVTQAQSPFR VYHYQFKIQF 

       370        380        390        400        410        420 
INQIEKPLEP TFTMSLLGTK EEMQKIPITL GEGITSNKTY SFLITLNLDI GELMVIKFKW 

       430        440        450        460        470        480 
ENSAVWANVW NTVQTIIPWG IKPRNSGLIL KTIRVKAGET QQRMTFCSEN MDDLQLHPTQ 

       490 
EKNFVRCEVN PKKLKLKIK 

« Hide

References

[1]"Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels."
Warren R.J., Ebert D.L., Mitchell A., Barter P.J.
J. Lipid Res. 32:1333-1339(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Warren R.J., Ebert D.L., Mitchell A., Barter P.J.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF041202 mRNA. Translation: AAB96786.1.
RefSeqNP_001075501.1. NM_001082032.1.
UniGeneOcu.2193.

3D structure databases

ProteinModelPortalO46559.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000001411.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100008678.

Organism-specific databases

CTD3990.

Phylogenomic databases

eggNOGNOG81747.
HOGENOMHOG000038553.
HOVERGENHBG002259.

Family and domain databases

Gene3D2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
PfamPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLIPC_RABIT
AccessionPrimary (citable) accession number: O46559
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families