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Protein

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168NucleophileBy similarity1
Active sitei194Charge relay systemPROSITE-ProRule annotation1
Active sitei279Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Protein family/group databases

ESTHERirabit-1hlip Hepatic_Lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
Gene namesi
Name:LIPC
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000023334123 – 499Hepatic triacylglycerol lipaseAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001411

Structurei

3D structure databases

ProteinModelPortaliO46559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 486PLATPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 193Heparin-bindingSequence analysisAdd BLAST13

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIHP Eukaryota
ENOG4110MCZ LUCA
HOGENOMiHOG000038553
HOVERGENiHBG002259
InParanoidiO46559
KOiK22283

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR002333 Lipase_hep
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PTHR11610:SF2 PTHR11610:SF2, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00824 HEPLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPLCVPIF LAVCILIQSS THGQSLRPEP FGRRARVTAT KKTLLETETR
60 70 80 90 100
FLLFKDKANK GCQIRLHHAD TLQECGFNSS LPLVMIVHGW SVDGLLESWI
110 120 130 140 150
WQMVAALKSQ PARPVNVGLV DWISLAHSHY AVAVRNARLV GQEVAALLQW
160 170 180 190 200
LEESAPFSRS NVHLIGYSLG AHVAGFAGSY ISGKHKIGRI TGLDAAGPLF
210 220 230 240 250
EGTSASDRLS PDDATFVDAI HTFTREHMGL SVGIKQPVGH YDFYPNGGSF
260 270 280 290 300
QPGCHFLELY KHIAQHGLNA LSQTIKCAHE RSVHLFIDSL LHPSMQSTAY
310 320 330 340 350
QCSDMDSFSQ GLCLGCTKGR CNTLGYHIRQ EPLSKGKRLF LVTQAQSPFR
360 370 380 390 400
VYHYQFKIQF INQIEKPLEP TFTMSLLGTK EEMQKIPITL GEGITSNKTY
410 420 430 440 450
SFLITLNLDI GELMVIKFKW ENSAVWANVW NTVQTIIPWG IKPRNSGLIL
460 470 480 490
KTIRVKAGET QQRMTFCSEN MDDLQLHPTQ EKNFVRCEVN PKKLKLKIK
Length:499
Mass (Da):55,814
Last modified:June 1, 1998 - v1
Checksum:i4DA7D65EE815A0A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041202 mRNA Translation: AAB96786.1
RefSeqiNP_001075501.1, NM_001082032.1
UniGeneiOcu.2193

Genome annotation databases

GeneIDi100008678
KEGGiocu:100008678

Similar proteinsi

Entry informationi

Entry nameiLIPC_RABIT
AccessioniPrimary (citable) accession number: O46559
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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