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Protein

Amiloride-sensitive sodium channel subunit delta

Gene

SCNN1D

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sensory transduction, Sodium transport, Taste, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Amiloride-sensitive sodium channel subunit delta
Alternative name(s):
Delta-NaCH
Epithelial Na(+) channel subunit delta
Short name:
Delta-ENaC
Nonvoltage-gated sodium channel 1 subunit delta
SCNED
Gene namesi
Name:SCNN1D
Synonyms:DNACH
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicBy similarityAdd
BLAST
Transmembranei87 – 10721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini108 – 530423ExtracellularBy similarityAdd
BLAST
Transmembranei531 – 55121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini552 – 63887CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Amiloride-sensitive sodium channel subunit deltaPRO_0000181283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis
Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Heterotrimer containing a delta/SCNN1D, a beta/SCNN1B and a gamma/SCNN1G subunit. The additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties.By similarity

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 4114Pro-richPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000236286.
HOVERGENiHBG058435.
InParanoidiO46547.
KOiK04826.

Family and domain databases

InterProiIPR004724. ENaC.
IPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
TIGRFAMsiTIGR00859. ENaC. 1 hit.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHRSMDGR MEAATRGGSH LQAAAQTPPR PGPPSAPPPP PKEGHQEGLV
60 70 80 90 100
ELPASFRELL TFFCTNATIH GAIRLVCSRG NRLKTTSWGL LSLGALVALC
110 120 130 140 150
WQLGLLFERH WHRPVLMAVS VHSERKLLPL VTLCDGNPRR PSPVLRHLEL
160 170 180 190 200
LDEFARENID SLYNVNLSQG RAALSAPVPR HEPPFHLDRE IRLQRLSHSG
210 220 230 240 250
SRVRVGFRLC NSTGGDCFYR GYTSGVAAVQ DWCHFHYVDI LALLPAAWED
260 270 280 290 300
SHGSQDGHFV LSCSYDGLDC QARQFRTFHH PTYGSCYTVD GVWTAQRPGI
310 320 330 340 350
THGVGLVLRV EQQPHLPLLS TLAGIRVMVH GRNHTPFLGH HSFSVRPGTE
360 370 380 390 400
ATISIREDEV HRLGSPYGHC TAGAEGVEVE LLHNTSYTRQ ACLVSCFQQL
410 420 430 440 450
MVETCSCGYY LHPLPAGAEY CSSARHPAWG HCFYRLYQDL ETHRLPCTSR
460 470 480 490 500
CPRPCRESAF KLSTGTSRWP SAKSAGWTLA TLGEQGLPRQ SHRQRSSLAK
510 520 530 540 550
INIVYQELNY RSVEEAPVYS VPQLLSAMGS LCSLWFGASV LSLLELLELL
560 570 580 590 600
LDASALTLVL GGRRLRRAWF SWPRASPASG ASSIKPEASQ MPTPAGGTSD
610 620 630
DPEPSGPHLP RVMLPGVLAG VSAEESWAGP QPLETLDT
Length:638
Mass (Da):70,188
Last modified:June 1, 1998 - v1
Checksum:i321E9597D6A78D38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038165 mRNA. Translation: AAB92659.1.
RefSeqiNP_001009072.1. NM_001009072.1.
UniGeneiPtr.6407.

Genome annotation databases

GeneIDi450189.
KEGGiptr:450189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038165 mRNA. Translation: AAB92659.1.
RefSeqiNP_001009072.1. NM_001009072.1.
UniGeneiPtr.6407.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi450189.
KEGGiptr:450189.

Organism-specific databases

CTDi6339.

Phylogenomic databases

HOGENOMiHOG000236286.
HOVERGENiHBG058435.
InParanoidiO46547.
KOiK04826.

Family and domain databases

InterProiIPR004724. ENaC.
IPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
TIGRFAMsiTIGR00859. ENaC. 1 hit.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCNND_PANTR
AccessioniPrimary (citable) accession number: O46547
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.