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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Propeptidei25 – 12298CuratedPRO_0000001511Add
BLAST
Peptidei123 – 15028Atrial natriuretic factorBy similarityPRO_0000001512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi129 ↔ 145By similarity

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.By similarity
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei122 – 1232Cleavage; by CORINBy similarity
Sitei129 – 1302Cleavage; by MMEBy similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004227.
KOiK12334.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSAITTSF LLFVAFQLPG QTGANPVYGS VSNADLMDFK NLLDRLEDKM
60 70 80 90 100
PLEDEAVPSQ VLSEQNEEAG APLSPLSEVP PWDGGRSTQP REMGAPSDGD
110 120 130 140 150
PGNPPRSVLL KSKLRALLTA PRSLRRSSCF GGRMDRIGAQ SGLGCNSFRY

RR
Length:152
Mass (Da):16,368
Last modified:June 1, 1998 - v1
Checksum:i5FA82C6E1325E7C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037465 Genomic DNA. Translation: AAB92564.1.
RefSeqiNP_001153499.1. NM_001160027.1.
UniGeneiOar.19887.

Genome annotation databases

GeneIDi100294648.
KEGGioas:100294648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037465 Genomic DNA. Translation: AAB92564.1.
RefSeqiNP_001153499.1. NM_001160027.1.
UniGeneiOar.19887.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100294648.
KEGGioas:100294648.

Organism-specific databases

CTDi4878.

Phylogenomic databases

HOVERGENiHBG004227.
KOiK12334.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The characterization of ovine genes for atrial, brain, and C-type natriuretic peptides."
    Aitken G.D., Raizis A.M., Yandle T.G., George P.M., Espiner E.A., Cameron V.A.
    Domest. Anim. Endocrinol. 16:115-121(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiANF_SHEEP
AccessioniPrimary (citable) accession number: O46540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: June 1, 1998
Last modified: April 1, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.