RGS7

Functionⁱ

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.By similarity

GO - Molecular functionⁱ

G-protein beta-subunit binding Source: Ensembl
GTPase activator activity Source: GO_Central
signal transducer activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: InterPro
intracellular signal transduction Source: InterPro
negative regulation of signal transduction Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation, Signal transduction inhibitor

Molecular function

GTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Reactomeⁱ

R-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 7 Short name: RGS7
Gene namesⁱ	Name:RGS7
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 16

Organism-specific databases

VGNCⁱ	VGNC:33923. RGS7.

VGNCⁱ

VGNC:33923. RGS7.

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204195	1 – 469	Regulator of G-protein signaling 7Add BLAST		469

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	229	PhosphoserineBy similarity	1
Modified residueⁱ	241	PhosphoserineBy similarity	1
Modified residueⁱ	243	PhosphothreonineBy similarity	1
Modified residueⁱ	434	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Palmitoylated.1 Publication

Ubiquitinated, leading to rapid proteasomal degradation.By similarity

Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.By similarity

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	O46470.
PRIDEⁱ	O46470.

PTM databases

SwissPalmⁱ	O46470.

SwissPalmⁱ

O46470.

Expressionⁱ

Tissue specificityⁱ

Detected in retina (at protein level) (PubMed:9731233).1 Publication

Gene expression databases

Bgeeⁱ	ENSBTAG00000005410.

Bgeeⁱ

ENSBTAG00000005410.

Interactionⁱ

Subunit structureⁱ

Interacts with PKD1; this prevents rapid proteasomal degradation. Interacts with GNB5 (PubMed:9731233). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (By similarity). Interacts (phosphorylated form) with 14-3-3 protein YWHAQ. Interacts with SNAPIN. Interacts with GNAI1 (By similarity). Interacts with GNAO1, GNAI3 and GNAZ (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

G-protein beta-subunit binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	O46470.
STRINGⁱ	9913.ENSBTAP00000051949.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O46470.
SMRⁱ	O46470.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	37 – 112	DEPPROSITE-ProRule annotationAdd BLAST	76
Domainⁱ	255 – 316	G protein gammaAdd BLAST	62
Domainⁱ	333 – 448	RGSPROSITE-ProRule annotationAdd BLAST	116

Phylogenomic databases

eggNOGⁱ	KOG3589. Eukaryota. ENOG410YMJD. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142.
HOGENOMⁱ	HOG000220864.
HOVERGENⁱ	HBG007404.
InParanoidⁱ	O46470.
KEGG Orthology (KO) More...KOⁱ	K16449.
OMAⁱ	QQQIKYW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05MO.
TreeFamⁱ	TF351956.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00068. GGL. 1 hit.
Gene3Dⁱ	1.10.10.10. 1 hit. 1.10.196.10. 2 hits.
InterProⁱ	View protein in InterPro IPR000591. DEP_dom. IPR015898. G-protein_gamma-like_dom. IPR036284. GGL_sf. IPR016137. RGS. IPR036305. RGS_sf. IPR024066. RGS_subdom1/3. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit.
PRINTSⁱ	PR01301. RGSPROTEIN.
SMARTⁱ	View protein in SMART SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit. SSF48097. SSF48097. 1 hit. SSF48670. SSF48670. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50186. DEP. 1 hit. PS50132. RGS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O46470-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL 
        60         70         80         90        100
SKIPSVFSGS DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT 
       110        120        130        140        150
LKDDGTFYRF QTPYFWPSNC WEPENTDYAV YLCKRTMQNK ARLELADYEA 
       160        170        180        190        200
ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK RDKIERKILD SQERAFWDVH 
       210        220        230        240        250
RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH SPTHTPTPET 
       260        270        280        290        300
KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLAPP 
       310        320        330        340        350
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF 
       360        370        380        390        400
LESEFSSENL RFWLAVEDLK KRPIREVPSR VQEIWQEFLA PGAPSAINLD 
       410        420        430        440        450
SKSYDKTTQN VKEPGRYTFE DAQEHIYKLM KSDSYPRFIR SSAYQELLQA 
       460 
KKKGKSLTSK RLTSLVQSY

Length:469

Mass (Da):54,685

Last modified:June 1, 1998 - v1

Checksum:ⁱ415C968DB272F450

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011359 mRNA. Translation: AAC99482.1. BC113238 mRNA. Translation: AAI13239.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_776594.1. NM_174169.2.
UniGeneⁱ	Bt.4470.

Genome annotation databases

Ensemblⁱ	ENSBTAT00000057157; ENSBTAP00000051949; ENSBTAG00000005410.
GeneIDⁱ	281452.
KEGGⁱ	bta:281452.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O46470	P49802-2 UPI00024CE3A9 UPI0007DC7704 UPI00051E3B53 UPI0004F1034B UPI00051EF887 UPI000522982B UPI0006711634 A0A2I0MUU7 UPI0002B498E5 +123	Homo sapiens (Human) Struthio camelus australis Serinus canaria (Island canary) (Fringilla canaria) Egretta garzetta (Little egret) Opisthocomus hoazin (Hoatzin) (Phasianus hoazin) Anser cygnoides domesticus Columba livia (Rock dove) Taeniopygia guttata (Zebra finch) (Poephila guttata) Cuculus canorus (common cuckoo) Haliaeetus leucocephalus (Bald eagle) And more	469	UniRef90_P49802-2	Cluster: Isoform 2 of Regulator of G-protein signaling 7	134

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O46470	P49802-2 UPI00024CE3A9 UPI0007DC7704 UPI00051E3B53 UPI000521746B UPI0006711634 UPI0004F43A4B UPI00053CE296 UPI0004C05CDA UPI0003833C3C +468	Homo sapiens (Human) Struthio camelus australis Charadrius vociferus (Killdeer) (Aegialitis vocifera) Anser cygnoides domesticus Aptenodytes forsteri (Emperor penguin) Haliaeetus leucocephalus (Bald eagle) Calypte anna (Anna's hummingbird) (Archilochus anna) Melopsittacus undulatus (Budgerigar) (Psittacus undulatus) Egretta garzetta (Little egret) Falco peregrinus (Peregrine falcon) And more	469	UniRef50_P49802-2	Cluster: Isoform 2 of Regulator of G-protein signaling 7	479

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011359 mRNA. Translation: AAC99482.1. BC113238 mRNA. Translation: AAI13239.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_776594.1. NM_174169.2.
UniGeneⁱ	Bt.4470.

3D structure databases

ProteinModelPortalⁱ	O46470.
SMRⁱ	O46470.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	O46470.
STRINGⁱ	9913.ENSBTAP00000051949.

PTM databases

SwissPalmⁱ	O46470.

SwissPalmⁱ

O46470.

Proteomic databases

PaxDbⁱ	O46470.
PRIDEⁱ	O46470.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000057157; ENSBTAP00000051949; ENSBTAG00000005410.
GeneIDⁱ	281452.
KEGGⁱ	bta:281452.

Organism-specific databases

CTDⁱ	6000.
VGNCⁱ	VGNC:33923. RGS7.

Phylogenomic databases

eggNOGⁱ	KOG3589. Eukaryota. ENOG410YMJD. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142.
HOGENOMⁱ	HOG000220864.
HOVERGENⁱ	HBG007404.
InParanoidⁱ	O46470.
KEGG Orthology (KO) More...KOⁱ	K16449.
OMAⁱ	QQQIKYW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05MO.
TreeFamⁱ	TF351956.

Enzyme and pathway databases

Reactomeⁱ	R-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Reactomeⁱ

R-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Gene expression databases

Bgeeⁱ	ENSBTAG00000005410.

Bgeeⁱ

ENSBTAG00000005410.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00068. GGL. 1 hit.
Gene3Dⁱ	1.10.10.10. 1 hit. 1.10.196.10. 2 hits.
InterProⁱ	View protein in InterPro IPR000591. DEP_dom. IPR015898. G-protein_gamma-like_dom. IPR036284. GGL_sf. IPR016137. RGS. IPR036305. RGS_sf. IPR024066. RGS_subdom1/3. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit.
PRINTSⁱ	PR01301. RGSPROTEIN.
SMARTⁱ	View protein in SMART SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit. SSF48097. SSF48097. 1 hit. SSF48670. SSF48670. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50186. DEP. 1 hit. PS50132. RGS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS7_BOVIN
Accessionⁱ	O46470Primary (citable) accession number: O46470 Secondary accession number(s): Q2HJA0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	June 1, 1998
	Last modified:	March 28, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

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Supporting data

UniProtKB - O46470 (RGS7_BOVIN)

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Regulator of G-protein signaling 7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma membrane

Other locations

Cytosol

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ