RGS7

Functionⁱ

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.By similarity

GO - Molecular functionⁱ

G-protein beta-subunit binding Source: Ensembl
GTPase activator activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: InterPro
intracellular signal transduction Source: InterPro
negative regulation of signal transduction Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation, Signal transduction inhibitor

Molecular function

GTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 7 Short name: RGS7
Gene namesⁱ	Name:RGS7
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 16

Organism-specific databases

VGNCⁱ	VGNC:33923 RGS7

VGNCⁱ

VGNC:33923 RGS7

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204195	1 – 469	Regulator of G-protein signaling 7Add BLAST		469

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	229	PhosphoserineBy similarity	1
Modified residueⁱ	241	PhosphoserineBy similarity	1
Modified residueⁱ	243	PhosphothreonineBy similarity	1
Modified residueⁱ	434	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Palmitoylated.1 Publication

Ubiquitinated, leading to rapid proteasomal degradation.By similarity

Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.By similarity

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	O46470
PRIDEⁱ	O46470

PTM databases

SwissPalmⁱ	O46470

SwissPalmⁱ

O46470

Expressionⁱ

Tissue specificityⁱ

Detected in retina (at protein level) (PubMed:9731233).1 Publication

Gene expression databases

Bgeeⁱ	ENSBTAG00000005410

Bgeeⁱ

ENSBTAG00000005410

Interactionⁱ

Subunit structureⁱ

Interacts with PKD1; this prevents rapid proteasomal degradation. Interacts with GNB5 (PubMed:9731233). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (By similarity). Interacts (phosphorylated form) with 14-3-3 protein YWHAQ. Interacts with SNAPIN. Interacts with GNAI1 (By similarity). Interacts with GNAO1, GNAI3 and GNAZ (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

G-protein beta-subunit binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	O46470
STRINGⁱ	9913.ENSBTAP00000051949

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O46470
SMRⁱ	O46470
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	37 – 112	DEPPROSITE-ProRule annotationAdd BLAST	76
Domainⁱ	255 – 316	G protein gammaAdd BLAST	62
Domainⁱ	333 – 448	RGSPROSITE-ProRule annotationAdd BLAST	116

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000220864
HOVERGENⁱ	HBG007404
InParanoidⁱ	O46470
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	QQQIKYW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05MO
TreeFamⁱ	TF351956

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00068 GGL, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR000591 DEP_dom IPR015898 G-protein_gamma-like_dom IPR036284 GGL_sf IPR016137 RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610 DEP, 1 hit PF00631 G-gamma, 1 hit PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00049 DEP, 1 hit SM00224 GGL, 1 hit SM00315 RGS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF48097 SSF48097, 1 hit SSF48670 SSF48670, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186 DEP, 1 hit PS50132 RGS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O46470-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL 
        60         70         80         90        100
SKIPSVFSGS DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT 
       110        120        130        140        150
LKDDGTFYRF QTPYFWPSNC WEPENTDYAV YLCKRTMQNK ARLELADYEA 
       160        170        180        190        200
ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK RDKIERKILD SQERAFWDVH 
       210        220        230        240        250
RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH SPTHTPTPET 
       260        270        280        290        300
KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLAPP 
       310        320        330        340        350
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF 
       360        370        380        390        400
LESEFSSENL RFWLAVEDLK KRPIREVPSR VQEIWQEFLA PGAPSAINLD 
       410        420        430        440        450
SKSYDKTTQN VKEPGRYTFE DAQEHIYKLM KSDSYPRFIR SSAYQELLQA 
       460 
KKKGKSLTSK RLTSLVQSY

Length:469

Mass (Da):54,685

Last modified:June 1, 1998 - v1

Checksum:ⁱ415C968DB272F450

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011359 mRNA Translation: AAC99482.1 BC113238 mRNA Translation: AAI13239.1
NCBI Reference Sequences More...RefSeqⁱ	NP_776594.1, NM_174169.2
UniGeneⁱ	Bt.4470

Genome annotation databases

Ensemblⁱ	ENSBTAT00000057157; ENSBTAP00000051949; ENSBTAG00000005410
GeneIDⁱ	281452
KEGGⁱ	bta:281452

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
O46470	UPI0007DC7704		HUMAN		443
UPI00051E3B53		Struthio camelus australis		545
UPI0002B498E5		TAEGU		506
UPI0004F43A4B		APTFO		506
UPI00051EF887		EGRGA		506
+130

Protein	Similar proteins		Species	Score	Length
O46470	UPI0007DC7704		HUMAN		443
UPI00051E3B53		Struthio camelus australis		545
UPI000521746B		CHAVO		506
UPI0006711634		Anser cygnoides domesticus		506
UPI0004F43A4B		APTFO		506
+479

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011359 mRNA Translation: AAC99482.1 BC113238 mRNA Translation: AAI13239.1
NCBI Reference Sequences More...RefSeqⁱ	NP_776594.1, NM_174169.2
UniGeneⁱ	Bt.4470

3D structure databases

ProteinModelPortalⁱ	O46470
SMRⁱ	O46470
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	O46470
STRINGⁱ	9913.ENSBTAP00000051949

PTM databases

SwissPalmⁱ	O46470

SwissPalmⁱ

O46470

Proteomic databases

PaxDbⁱ	O46470
PRIDEⁱ	O46470

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000057157; ENSBTAP00000051949; ENSBTAG00000005410
GeneIDⁱ	281452
KEGGⁱ	bta:281452

Organism-specific databases

CTDⁱ	6000
VGNCⁱ	VGNC:33923 RGS7

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000220864
HOVERGENⁱ	HBG007404
InParanoidⁱ	O46470
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	QQQIKYW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05MO
TreeFamⁱ	TF351956

Enzyme and pathway databases

Reactomeⁱ	R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Gene expression databases

Bgeeⁱ	ENSBTAG00000005410

Bgeeⁱ

ENSBTAG00000005410

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00068 GGL, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR000591 DEP_dom IPR015898 G-protein_gamma-like_dom IPR036284 GGL_sf IPR016137 RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610 DEP, 1 hit PF00631 G-gamma, 1 hit PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00049 DEP, 1 hit SM00224 GGL, 1 hit SM00315 RGS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF48097 SSF48097, 1 hit SSF48670 SSF48670, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186 DEP, 1 hit PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS7_BOVIN
Accessionⁱ	O46470Primary (citable) accession number: O46470 Secondary accession number(s): Q2HJA0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	June 1, 1998
	Last modified:	June 20, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - O46470 (RGS7_BOVIN)

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Regulator of G-protein signaling 7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Other locations

Cytosol

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ