UniProtKB - O46470 (RGS7_BOVIN)
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Protein
Regulator of G-protein signaling 7
Gene
RGS7
Organism
Bos taurus (Bovine)
Status
Functioni
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.By similarity
GO - Molecular functioni
- G-protein beta-subunit binding Source: Ensembl
- GTPase activator activity Source: GO_Central
- signal transducer activity Source: InterPro
GO - Biological processi
- G-protein coupled receptor signaling pathway Source: InterPro
- intracellular signal transduction Source: InterPro
- negative regulation of signal transduction Source: UniProtKB-KW
Keywordsi
Molecular function | GTPase activation, Signal transduction inhibitor |
Enzyme and pathway databases
Reactomei | R-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding. |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 7Short name: RGS7 |
Gene namesi | Name:RGS7 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:33923. RGS7. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204195 | 1 – 469 | Regulator of G-protein signaling 7Add BLAST | 469 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 229 | PhosphoserineBy similarity | 1 | |
Modified residuei | 241 | PhosphoserineBy similarity | 1 | |
Modified residuei | 243 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 434 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Palmitoylated.1 Publication
Ubiquitinated, leading to rapid proteasomal degradation.By similarity
Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.By similarity
Keywords - PTMi
Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O46470. |
PRIDEi | O46470. |
PTM databases
SwissPalmi | O46470. |
Expressioni
Tissue specificityi
Detected in retina (at protein level) (PubMed:9731233).1 Publication
Gene expression databases
Bgeei | ENSBTAG00000005410. |
Interactioni
Subunit structurei
Interacts with PKD1; this prevents rapid proteasomal degradation. Interacts with GNB5 (PubMed:9731233). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (By similarity). Interacts (phosphorylated form) with 14-3-3 protein YWHAQ. Interacts with SNAPIN. Interacts with GNAI1 (By similarity). Interacts with GNAO1, GNAI3 and GNAZ (By similarity).By similarity1 Publication
GO - Molecular functioni
- G-protein beta-subunit binding Source: Ensembl
Protein-protein interaction databases
CORUMi | O46470. |
STRINGi | 9913.ENSBTAP00000051949. |
Structurei
3D structure databases
ProteinModelPortali | O46470. |
SMRi | O46470. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 112 | DEPPROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 255 – 316 | G protein gammaAdd BLAST | 62 | |
Domaini | 333 – 448 | RGSPROSITE-ProRule annotationAdd BLAST | 116 |
Phylogenomic databases
eggNOGi | KOG3589. Eukaryota. ENOG410YMJD. LUCA. |
GeneTreei | ENSGT00760000119142. |
HOGENOMi | HOG000220864. |
HOVERGENi | HBG007404. |
InParanoidi | O46470. |
KOi | K16449. |
OMAi | QQQIKYW. |
OrthoDBi | EOG091G05MO. |
TreeFami | TF351956. |
Family and domain databases
CDDi | cd00068. GGL. 1 hit. |
Gene3Di | 1.10.10.10. 1 hit. 1.10.196.10. 2 hits. |
InterProi | View protein in InterPro IPR000591. DEP_dom. IPR015898. G-protein_gamma-like_dom. IPR036284. GGL_sf. IPR016137. RGS. IPR036305. RGS_sf. IPR024066. RGS_subdom1/3. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf. |
Pfami | View protein in Pfam PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit. |
PRINTSi | PR01301. RGSPROTEIN. |
SMARTi | View protein in SMART SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. SSF48097. SSF48097. 1 hit. SSF48670. SSF48670. 1 hit. |
PROSITEi | View protein in PROSITE PS50186. DEP. 1 hit. PS50132. RGS. 1 hit. |
i Sequence
Sequence statusi: Complete.
O46470-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL
60 70 80 90 100
SKIPSVFSGS DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT
110 120 130 140 150
LKDDGTFYRF QTPYFWPSNC WEPENTDYAV YLCKRTMQNK ARLELADYEA
160 170 180 190 200
ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK RDKIERKILD SQERAFWDVH
210 220 230 240 250
RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH SPTHTPTPET
260 270 280 290 300
KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLAPP
310 320 330 340 350
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF
360 370 380 390 400
LESEFSSENL RFWLAVEDLK KRPIREVPSR VQEIWQEFLA PGAPSAINLD
410 420 430 440 450
SKSYDKTTQN VKEPGRYTFE DAQEHIYKLM KSDSYPRFIR SSAYQELLQA
460
KKKGKSLTSK RLTSLVQSY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF011359 mRNA. Translation: AAC99482.1. BC113238 mRNA. Translation: AAI13239.1. |
RefSeqi | NP_776594.1. NM_174169.2. |
UniGenei | Bt.4470. |
Genome annotation databases
Ensembli | ENSBTAT00000057157; ENSBTAP00000051949; ENSBTAG00000005410. |
GeneIDi | 281452. |
KEGGi | bta:281452. |
Similar proteinsi
Entry informationi
Entry namei | RGS7_BOVIN | |
Accessioni | O46470Primary (citable) accession number: O46470 Secondary accession number(s): Q2HJA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |