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UniProtKB - O46470 (RGS7_BOVIN)

UniProt

O46470 - RGS7_BOVIN

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Protein

Regulator of G-protein signaling 7

Gene

RGS7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 7
Short name:
RGS7
Gene namesi
Name:RGS7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

  • Cytoplasm › cytosol By similarity
  • Cytoplasm By similarity
  • Cell membrane By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    • Note: Interaction with PKD1 promotes location at the cell membrane. Interaction with RGS7BP promotes location at the cell membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Regulator of G-protein signaling 7PRO_0000204195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291PhosphoserineBy similarity
Modified residuei241 – 2411PhosphoserineBy similarity
Modified residuei243 – 2431PhosphothreonineBy similarity
Modified residuei434 – 4341PhosphoserineBy similarity

Post-translational modificationi

Palmitoylated.1 Publication
Ubiquitinated, leading to rapid proteasomal degradation.By similarity
Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO46470.
PRIDEiO46470.

PTM databases

SwissPalmiO46470.

Expressioni

Tissue specificityi

Detected in retina (at protein level) (PubMed:9731233).1 Publication

Gene expression databases

BgeeiENSBTAG00000005410.

Interactioni

Subunit structurei

Interacts with PKD1; this prevents rapid proteasomal degradation. Interacts with GNB5 (PubMed:9731233). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (By similarity). Interacts (phosphorylated form) with 14-3-3 protein YWHAQ. Interacts with SNAPIN. Interacts with GNAI1 (By similarity). Interacts with GNAO1, GNAI3 and GNAZ (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051949.

Structurei

3D structure databases

ProteinModelPortaliO46470.
SMRiO46470. Positions 320-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 11276DEPPROSITE-ProRule annotationAdd
BLAST
Domaini255 – 31662G protein gammaAdd
BLAST
Domaini333 – 448116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiO46470.
KOiK16449.
OMAiDASCPIN.
OrthoDBiEOG091G05MO.
TreeFamiTF351956.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL 
        60         70         80         90        100
SKIPSVFSGS DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT 
       110        120        130        140        150
LKDDGTFYRF QTPYFWPSNC WEPENTDYAV YLCKRTMQNK ARLELADYEA 
       160        170        180        190        200
ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK RDKIERKILD SQERAFWDVH 
       210        220        230        240        250
RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH SPTHTPTPET 
       260        270        280        290        300
KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLAPP 
       310        320        330        340        350
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF 
       360        370        380        390        400
LESEFSSENL RFWLAVEDLK KRPIREVPSR VQEIWQEFLA PGAPSAINLD 
       410        420        430        440        450
SKSYDKTTQN VKEPGRYTFE DAQEHIYKLM KSDSYPRFIR SSAYQELLQA 
       460 
KKKGKSLTSK RLTSLVQSY
Length:469
Mass (Da):54,685
Last modified:June 1, 1998 - v1
Checksum:i415C968DB272F450
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011359 mRNA. Translation: AAC99482.1.
BC113238 mRNA. Translation: AAI13239.1.
RefSeqiNP_776594.1. NM_174169.2.
UniGeneiBt.4470.

Genome annotation databases

EnsembliENSBTAT00000057157; ENSBTAP00000051949; ENSBTAG00000005410.
GeneIDi281452.
KEGGibta:281452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011359 mRNA. Translation: AAC99482.1.
BC113238 mRNA. Translation: AAI13239.1.
RefSeqiNP_776594.1. NM_174169.2.
UniGeneiBt.4470.

3D structure databases

ProteinModelPortaliO46470.
SMRiO46470. Positions 320-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051949.

PTM databases

SwissPalmiO46470.

Proteomic databases

PaxDbiO46470.
PRIDEiO46470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000057157; ENSBTAP00000051949; ENSBTAG00000005410.
GeneIDi281452.
KEGGibta:281452.

Organism-specific databases

CTDi6000.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiO46470.
KOiK16449.
OMAiDASCPIN.
OrthoDBiEOG091G05MO.
TreeFamiTF351956.

Enzyme and pathway databases

ReactomeiR-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Gene expression databases

BgeeiENSBTAG00000005410.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS7_BOVIN
AccessioniPrimary (citable) accession number: O46470
Secondary accession number(s): Q2HJA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.