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Protein

Regulator of G-protein signaling 9

Gene

RGS9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9
Short name:
RGS9
Gene namesi
Name:RGS9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042021 – 484Regulator of G-protein signaling 9Add BLAST484

Post-translational modificationi

Phosphorylation is decreased by light exposition.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO46469.
PRIDEiO46469.

PTM databases

iPTMnetiO46469.

Expressioni

Tissue specificityi

Photoreceptor outer segments.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP (Probable).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GNB5A5PJS15EBI-6949890,EBI-6949917

Protein-protein interaction databases

IntActiO46469. 2 interactors.
STRINGi9913.ENSBTAP00000023605.

Structurei

Secondary structure

1484
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi282 – 284Combined sources3
Helixi290 – 295Combined sources6
Turni296 – 298Combined sources3
Helixi300 – 304Combined sources5
Helixi307 – 319Combined sources13
Helixi324 – 336Combined sources13
Helixi340 – 342Combined sources3
Helixi343 – 354Combined sources12
Helixi367 – 376Combined sources10
Turni382 – 385Combined sources4
Helixi386 – 399Combined sources14
Helixi401 – 405Combined sources5
Helixi408 – 416Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQIX-ray1.94A276-422[»]
1FQJX-ray2.02B/E276-422[»]
1FQKX-ray2.30B/D276-422[»]
ProteinModelPortaliO46469.
SMRiO46469.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO46469.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105DEPPROSITE-ProRule annotationAdd BLAST76
Domaini219 – 280G protein gammaAdd BLAST62
Domaini299 – 414RGSPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiO46469.
KOiK13765.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIRHQGQQY RPRMAFLRKI EALVKDMQDP DTGVRVQNQK VKVVSIPHAM
60 70 80 90 100
TGSDVLQWIS QRLWISGLEA QNLGNFIVKY GYIYPLQDPR NLTLKPDSSL
110 120 130 140 150
YRFQTPYFWP TQQWPAEDVD YAIYLAKRNI KKKGILEEYE KENYNFLNKK
160 170 180 190 200
INYKWDFVIM QAREQYRAGK ERNKVDRCAL DCQEKAYWLV HRCPPGANNV
210 220 230 240 250
LDYGLDRVTN PNEDQKQTVV SVRKEIMYYR QALMRSTVKS SVSLGGIVKY
260 270 280 290 300
SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVDIPTK MRVERWAFNF
310 320 330 340 350
SELIRDPKGR QSFQHFLRKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI
360 370 380 390 400
YKLFLAPGAR RWINIDGKTM DITVKGLKHP HRYVLDAAQT HIYMLMKKDS
410 420 430 440 450
YARYLKSPIY KEMLAKAIEP QGTTRKSSSL PFMRRHLRSS PSPVILRQLE
460 470 480
EEAKAREAAT TVDITQVMSK LDRRSQLRKE PPPK
Length:484
Mass (Da):56,680
Last modified:June 1, 1998 - v1
Checksum:i3D8C61CEC1E22949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011357 mRNA. Translation: AAC99480.1.
RefSeqiNP_776595.1. NM_174170.2.
UniGeneiBt.97062.

Genome annotation databases

GeneIDi281453.
KEGGibta:281453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011357 mRNA. Translation: AAC99480.1.
RefSeqiNP_776595.1. NM_174170.2.
UniGeneiBt.97062.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQIX-ray1.94A276-422[»]
1FQJX-ray2.02B/E276-422[»]
1FQKX-ray2.30B/D276-422[»]
ProteinModelPortaliO46469.
SMRiO46469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO46469. 2 interactors.
STRINGi9913.ENSBTAP00000023605.

PTM databases

iPTMnetiO46469.

Proteomic databases

PaxDbiO46469.
PRIDEiO46469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281453.
KEGGibta:281453.

Organism-specific databases

CTDi8787.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiO46469.
KOiK13765.

Enzyme and pathway databases

ReactomeiR-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

EvolutionaryTraceiO46469.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS9_BOVIN
AccessioniPrimary (citable) accession number: O46469
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.